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Application of alantolactone and derivatives thereof in preventing and treating fatty liver damage

A technology for inulin and isoinulin, which is applied in the field of preparation, prevention and treatment of fatty liver damage, can solve problems such as unreported effects, achieve good curative effect, relieve lipid metabolism disorder, and improve liver function and liver function. Effects of Dyslipidemia

Active Publication Date: 2017-12-15
NORTHEAST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past, the understanding of the pharmacological effects of inulin mainly focused on the anti-tumor, anti-inflammatory, anthelmintic, antibacterial, hypoglycemic and analgesic effects. There is no report that inulin or its derivatives can prevent and treat fatty liver formation and Anti-fatty liver damage

Method used

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  • Application of alantolactone and derivatives thereof in preventing and treating fatty liver damage
  • Application of alantolactone and derivatives thereof in preventing and treating fatty liver damage
  • Application of alantolactone and derivatives thereof in preventing and treating fatty liver damage

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preparation example Construction

[0051] For the preparation method of inulin, see Kaur Ramandeep, Chahal, Bhardwai, et al. Asian Journal of Chemistry, 2017, 29(3): 568-570.;

[0052] Preparation method of isointracellactone, 13-methoxydihydro-inectinolactone, 13-methoxydihydro-inectinolactone, dihydroinectinolactone and dihydroinectinolactone See Marshall, Cphen. Journal of Organic Chemistry, 1964, 29:2773.;

[0053] For the preparation method of 13-benzylamine-oleumolide, see patent 201510031441.2 (Chen Jia, Gao Kun, Yuan Chunjuan. The use and preparation method of 13-benzylamine-oleumolide, a eucalyptane-type natural product derivative. Intellectual Property Office of the People's Republic of China);

[0054] Methyl cyanoacetate inulin, dimethyl malonate inulin, diethyl malonate inulin, nitromethane isoinulin, nitroethane isoinulin, See Guo Ruixia for the preparation methods of ethyl acetoacetate isocyanolide, p-chlorophenylisoxanolide, p-benzoisoxanolide, p-tolueneisoxanolide, and p-methoxybenzisoxanolid...

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Abstract

The invention discloses a new medical application of alantolactone and derivatives thereof, and particularly relates to an application of alantolactone and derivatives thereof in preventing and treating fatty liver damage. The alantolactone and derivatives thereof can relieve the lipid metabolism disorder of liver cells, inhibit oxLDL-induced TG and TC levels in liver cells and lipid droplet accumulation in cells, prevent and treat liver damage caused by alcoholic fatty liver diseases, effectively improve the liver function, effectively relieve dyslipidemia, and prevent and treat liver damage caused by non-alcoholic fatty liver diseases. Compared with various existing lipid-lowering drugs, the alantolactone and derivatives thereof have the advantages of being small in toxic and side effect and good in treatment effect, and have the potential of being developed into natural low-toxicity lipid-lowering drugs with clinical application value.

Description

technical field [0001] The invention discloses a new medical application of inulin and its derivatives, especially the application in the preparation, prevention and treatment of fatty liver injury, and belongs to the field of biomedicine. Background technique [0002] In recent years, due to the influence of various factors such as living habits and diet structure, the incidence of fatty liver in my country has gradually increased, and fatty liver can occur in people of different ages and genders. Fatty liver has become one of the common chronic diseases of contemporary humans, becoming the second major liver disease after viral hepatitis. [0003] Fatty liver is a fatty lesion of the liver caused by a variety of reasons. When the lipid accumulation in the liver cells exceeds 5%, or when more than 1 / 3 of the liver cells per unit area is histologically fatty, it is called fatty liver. The pathogenesis of fatty liver has not been clarified so far. Modern medicine believes th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P1/16
CPCA61K31/365
Inventor 鲍永利杨媚婷李玉新
Owner NORTHEAST NORMAL UNIVERSITY
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