Production line for tenofovir

Abstract

The invention discloses a production line for tenofovir. The production line comprises a primary reaction still, a low-temperature reaction still, a distillation type reaction still, a secondary reaction still and a recovery settling tank, wherein the primary reaction still comprises a reaction still body and at least two material uniformizing boards; rotating shafts are respectively arranged at two ends of the material uniformizing boards; a material uniformizing board mounting support is arranged in the reaction still; a gear is arranged on the rotating shaft at one end of each material uniform distribution board. The production line disclosed by the invention is reasonable in structural design; the primary reaction still blocks rotating liquid in the reaction still by the material uniformizing boards, so that the stirring efficiency is improved; meanwhile, angles of the material uniformizing boards can be adjusted according to the stirring progress of the liquid in the reaction still, so as to change the flowing speed of the liquid in the reaction still; the low-temperature reaction still adopts an electric sliding table to drive fan type stirring blades; because of a fluid principle, the stirring blades automatically rotate in a vertical moving process, and further the aim of stirring is achieved; besides, motor power and a calorific value are both reduced; the efficiency of an evolution reaction is high, distillation efficiency of the distillation type reaction still is high, the purity of a product is high, and a good practical value is realized.

Description

technical field [0001] The invention relates to the technical field of tenofovir production, in particular to a tenofovir production line. Background technique [0002] Tenofovir (Compound I), also known as Tenofovir, Chinese full name: (R is used in the secondary precipitation reaction kettle of Tenofovir production line)-9-(2-phosphomethoxypropyl)-adeno Purine is used in the secondary precipitation reaction of tenofovir production line, which is an AIDS antiviral drug. Tenofovir is also a better AIDS antiviral drug. Tenofofumarate fumarate is used in the tenofovir production line The key intermediate of vir dipivoxil (used in the secondary precipitation reactor II of tenofovir production line). In the tenofovir production line, it is necessary to stir the primary reaction solution with brine to precipitate HPA product crystals. The existing low-temperature reactor uses a high-power motor for stirring, which not only wastes energy, but also increases additional heat and hi...

AI Technical Summary

Problems solved by technology

In the tenofovir production line, it is necessary to stir the primary reaction solution with brine to precipitate HPA product crystals. The existing low-temperature reactor uses a high-power motor for stirring, which not only wastes energy, but also increases additional heat and hinders the precipitation. reaction

Diethyl tenofovir is produced by distillation. The existing distillation reactor has low distillation efficiency and low product purity.

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