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Triene mycin compound, preparation method and application thereof in treating prostatic cancer

A technology for trienycin and prostate cancer, which is applied in the field of medicine and can solve problems such as slow development

Active Publication Date: 2017-11-24
NORTHWEST A & F UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Trienycin is a typical class of benzamycin, since the first trienymycin was isolated in 1985 [6] , its development speed is slow, but because of its significant inhibitory activity on a variety of tumor cells, researchers are still enthusiastic about its research, but it is urgent to find new low-toxicity, high-activity trienycin, for the development of new anticancer drugs

Method used

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  • Triene mycin compound, preparation method and application thereof in treating prostatic cancer
  • Triene mycin compound, preparation method and application thereof in treating prostatic cancer
  • Triene mycin compound, preparation method and application thereof in treating prostatic cancer

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Embodiment Construction

[0059] The four compounds trienycin 1-4 of the present invention are isolated from a fermented liquid of Streptomyces cocoa subsp. The strain was isolated and identified by Xue Quanhong's research group at the School of Resources and Environment, Northwest Agriculture and Forestry University. The GenBank number is KF620296, and the strain number is H2S5. [9] . The strains are preserved in the Research Center of Natural Medicinal Chemistry, School of Chemistry and Pharmacy, Northwest A&F University, No. CA20151025. The strain was recorded in "Research on Microbial Flora and Antagonistic Actinomycetes Resources in 5 Habitats on the North Slope of Taibai Mountain, the Main Peak of the Qinling Mountains", Wang Dongsheng et al., "Journal of Northwest A&F University" 2014, and the applicant promised that within the validity period of the patent, free This strain is made available to the public.

[0060] The storage and activation culture conditions of the Streptomyces cocoa subsp....

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Abstract

The invention discloses a triene mycin compound, a preparation method and application thereof in treating prostatic cancer, particularly relates to four triene mycin compounds, a preparation method and active application thereof in resisting cells PC-3 of prostatic cancers, and discloses a chemical structural formula, physical and chemical properties and corresponding nuclear magnetism data of the compounds. The compound is separated from fermenting liquid of streptomyces cacaoi subsp.asoensis separated from moss soil of north slope of Taibai Mountain at main peak of Qinling; the strain is separated and identified by the Xuhongquan topic group of Resource and Environment Institute of Northwest Agriculture and Forestry University, the number of GenBank is KF620296, the number of strain is H2S5, the strain is collected into the Natural Medicine Chemical Study Center of Chemical and Medicine Institute of Northwest Agriculture and Forestry University, and the collection number is No.CA20151025.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to trienmycin compounds, a preparation method and application thereof for treating prostate cancer, in particular to four trienmycin compounds, a preparation method and application thereof for resisting prostate cancer cell PC-3. Background technique [0002] Natural products are the best source for drug development. According to the statistics of David J.Newman in 2016 [1] During the 74 years from 1940 to 2014, a total of 246 anticancer drugs were launched, of which 161 were related to natural products, accounting for 65% of the total. And there are 30 kinds of anticancer drugs directly derived from natural products, accounting for 12% of the total. It can be seen that natural products play a vital role in the development of anti-cancer drugs. However, in recent years, human health has been increasingly endangered by cancer. At the same time, the speed of human development of anti-cancer dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D225/06A61P35/00C12P17/10C12R1/465
CPCC07D225/06C12P17/10
Inventor 高锦明唐丹刘玲丽严雯汤江江薛泉宏
Owner NORTHWEST A & F UNIV
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