Non-oily doramectin injection and its preparation method and application

A doramectin and non-oily technology, which is applied in the field of non-oily doramectin injection and its preparation, can solve the problems of easy rancidity or discoloration of oils and fats, high difficulty of filtration sterilization, and poor application effect, so as to promote dissolution , The preparation method is simple and efficient, and the use effect is good

Active Publication Date: 2019-11-08
FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, oils are prone to rancidity or discoloration when exposed to light or air, resulting in poor stability
In addition, the viscosity of doramectin injection is very high, it is difficult to filter and sterilize, and it is difficult to withdraw the needle during use, and it is easy to accumulate bulges at the injection site, which will cause pain reactions, strong irritation, and poor application effect

Method used

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  • Non-oily doramectin injection and its preparation method and application
  • Non-oily doramectin injection and its preparation method and application
  • Non-oily doramectin injection and its preparation method and application

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preparation example Construction

[0036] A preparation method of the above-mentioned non-oily doramectin injection, comprising the following steps:

[0037] Get 0.1%-10% doramectin by weight percentage, and join in the solvent that glycerol formal and propylene glycol are mixed, wherein, the mass ratio of this glycerol formal and this propylene glycol is (4-8): (2- 6);

[0038] The solvent is mixed with the doramectin, stirred evenly, followed by nitrogen blowing, sub-packaging, capping, sterilization, qualified lamp inspection and packaging to obtain the non-oily doramectin injection.

[0039] In addition, it is also necessary to provide a non-oily doramectin injection for the prevention, treatment or control of parasites in animals.

[0040] The non-oily doramectin injection of the present invention can be used for deworming in and out of animals such as poultry and livestock. For example, the injection can be used for subcutaneous or intramuscular injection of animals for deworming in vivo, or the injecti...

Embodiment 1

[0043] Weigh each raw material with the following weight percentage (take the total amount of 100ml as an example)

[0044] Doramectin 1%, glycerol formal 59.4% and propylene glycol 39.6%.

[0045] 1) Add glycerol formal and propylene glycol to the stirring tank, and mix well;

[0046] 2) Doramectin was added to the stirring tank in step 1), stirred for 15 minutes to complete dissolution;

[0047] 3) The solution obtained in step 2) is sub-packed by nitrogen blowing, capping, sterilized, qualified for lamp inspection, and packaged to obtain non-oily doramectin injection 1.

Embodiment 2

[0049] Weigh each raw material with the following weight percentage (take the total amount of 100ml as an example)

[0050] Doramectin 1%, glycerol formal 39.7% and propylene glycol 59.3%.

[0051] The preparation method of the non-oily doramectin injection 2 is the same as that of Example 1.

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Abstract

The invention relates to a non-oily doramectin injection, a preparation method and application thereof. The non-oily doramectin injection comprises the following components: doramectin, glycerol formal and propylene glycol; wherein, the weight percentage of the doramectin is 0.1%-10%, and the glycerol formal and the The propylene glycol forms a mixed solvent, and the mass ratio of the glycerin formal and the propylene glycol in the mixed solvent is (4-8):(2-6). The non-oily doramectin injection has good stability and low irritation.

Description

technical field [0001] The technical field of antiparasitic drugs of the present invention, in particular relates to a non-oily doramectin injection and its preparation method and application. Background technique [0002] Doramectin (CAS accession number is 11774-25-3) is a new generation of macrolide antiparasitic drugs, the chemical name is 25-cyclohexyl-5-0-desmethyl-25-des(1- Methylpropyl) Abamectin Ala, the chemical formula is C 50 h 74 o 14 . Compared with traditional avermectin drugs, doramectin has good pharmacokinetic characteristics, and its drug effect maintenance time is increased by 30% compared with ivermectin. Therefore, doramectin has a good market prospect as a veterinary antiparasitic drug. [0003] The insecticidal mechanism of doramectins is mainly to interfere with the neurophysiological activities of parasites, which can stimulate arthropods, nematodes and other parasites to release inhibitory neurotransmitters (such as GABA), and then paralyze an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/7048A61K47/10A61P33/10A61P33/00
CPCA61K9/0019A61K9/08A61K31/7048A61K47/10
Inventor 李成应元晓琪付良凯孙迎江国亮
Owner FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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