Albendazole and ivermectin premixing agent and preparation method thereof

A technology of albendazole ivermectin and ivermectin, which is applied in the field of albendazole ivermectin premix and its preparation, can solve problems such as poisoning and teratogenicity, achieve small side effects, The effect of easy operation and simple steps

Active Publication Date: 2017-11-17
GUANGDONG WENS DAHUANONG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The main ingredient of this product, albendazole, has teratogenic effect; overdose of ivermectin can cause poisoning, and there is no specific antidote

Method used

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  • Albendazole and ivermectin premixing agent and preparation method thereof
  • Albendazole and ivermectin premixing agent and preparation method thereof
  • Albendazole and ivermectin premixing agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The prepared albendazole ivermectin premix comprises the following components in mass percentage:

[0040] Albendazole 5.8%

[0041] Ivermectin 0.24%

[0042] An Gong Bao Bao plant extract essence 5%

[0043] Medicinal charcoal 12%

[0044] Corn cob powder 2.0%

[0045] Add starch to full amount.

[0046] The preparation method of described albendazole ivermectin premix comprises the steps:

[0047] (1) Accurately weigh each component according to the above mass percentage, pass through a No. 5 sieve, and set aside;

[0048] (2) Premix of ivermectin:

[0049] Take starch and corncob powder and mix them in a mass ratio of 5:1 to 1:1 to form an auxiliary material a with a density equal to that of ivermectin;

[0050] Take the ivermectin of formula quantity and the auxiliary material a of equal amount and fully mix evenly, obtain ivermectin premixture 1;

[0051] Then take starch and corncob powder and mix them into an auxiliary material b with a density equal to t...

Embodiment 2

[0057] The prepared albendazole ivermectin premix comprises the following components in mass percentage:

[0058] Albendazole 6.0%

[0059] Ivermectin 0.25%

[0060] An Gong Bao Bao plant extract essence 5%

[0061] Medicinal charcoal 12%

[0062] Corn cob flour 2.3%

[0063] Add starch to full amount.

[0064] The preparation method is the same as in Example 1.

Embodiment 3

[0066] The prepared albendazole ivermectin premix comprises the following components in mass percentage:

[0067] Albendazole 6.3%

[0068] Ivermectin 0.26%

[0069] An Gong Bao Bao plant extract essence 5%

[0070] Medicinal charcoal 12%

[0071] Corn cob flour 2.6%

[0072] Add starch to full amount.

[0073] The preparation method is the same as in Example 1.

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Abstract

The invention discloses an albendazole and ivermectin premixing agent and a preparation method thereof. The premixing agent comprises the following components, by mass, of 5.5-6.5% of albendazole, 0.22-0.26% of ivermectin, 10-15% of medicinal carbon, 5-10% of corncob powder, 4.5-5.5% of yasumiya and tocolytic plant extracting essence and the balance starch. In preparation, the yasumiya and tocolytic plant extracting essence is added in a formula so that the side effect of the albendazole can be reduced. An equidensity and equivalent progressively-increasing mixing method is adopted for preparation so that effective guarantee can be provided for safe using of the premixing agent. The prepared albendazole and ivermectin premixing agent is small in effective component content deviation, small in side effect and capable of being used for pregnant domestic animals; the preparation step is simple and convenient and easy to operate; and the measured A+1.80S average value of the content uniformity of the ivermectin is smaller than 10.0 (according to the national standard, the A+1.80S average value is smaller than 15.0).

Description

technical field [0001] The invention relates to an albendazole ivermectin premix and a preparation method thereof, belonging to the fields of biotechnology and biomedicine. Background technique [0002] Albendazole ivermectin premix is ​​an antiparasitic drug. Albendazole has a broad-spectrum anthelmintic activity, and has a strong killing effect on nematodes, tapeworms, and trematodes. Its mechanism of action is to bind to tubulin in worms and prevent it from multimerizing with α-tubulin to form microtubules, thereby affecting cell reproduction processes such as mitosis, protein assembly and energy metabolism in worms. [0003] Ivermectin has a good repelling effect on internal and external parasites, especially arthropod insects and internal nematodes, and is mainly used to expel gastrointestinal nematodes, lung nematodes and external parasites in pigs. Its deworming mechanism is to promote the release of γ-aminobutyric acid (GABA) from presynaptic neurons, thereby openi...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/14A61K31/4184A61P33/00
CPCA61K9/146A61K31/4184A61K31/7048A61K2300/00
Inventor 廖陶雪方炳虎程含波颜进炽陈日波
Owner GUANGDONG WENS DAHUANONG BIOTECH
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