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Preparation method for gossypol and preparation method for gossypol acetate

A technology of gossypol acetate and gossypol, which is applied in the preparation of organic compounds, carboxylate salts, carboxylate salts, etc., can solve the problem of high cost, and achieve the effects of increased yield, wide application prospects, and low price

Inactive Publication Date: 2017-10-27
新疆维吾尔自治区中药民族药研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The invention provides a method for preparing gossypol and gossypol acetate, which overcomes the above-mentioned deficiencies in the prior art, and can effectively solve the problem of high cost in the existing gossypol extraction process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023]Embodiment 1: The preparation method of this gossypol is carried out according to the following steps: the first step, the raw material containing gossypol is used as a raw material, and the raw material adopts a borate aqueous solution with a mass concentration of 1% to 3% at a temperature of 10°C extraction at 60°C for 2 to 3 times, combine the extracts, filter the combined extracts to obtain the gossypol-containing extract; the second step, wash the gossypol-containing extract with an organic solvent, Discard organic layer, stay water layer; The 3rd step, in the water layer that the 2nd step obtains, add 1 / 3 to 1 / 2 times the diethyl ether of raw material weight and stir, add acid wherein under stirring state, water Adjust the pH value of the layer to 1 to 3, then stir and extract, and after stirring and extracting for 10 minutes to 30 minutes, separate the ether extract A and the extract water layer, extract the extract water layer with ether for 2 to 3 times to obtain...

Embodiment 2

[0033] Embodiment 2: The preparation method of this gossypol is carried out according to the following steps: the first step, the raw material containing gossypol is used as a raw material, and the raw material adopts a borate aqueous solution with a mass concentration of 1% or 3% at a temperature of 10°C Or extracting 2 or 3 times under the condition of 60°C, combining the extracts, filtering the combined extracts to obtain the gossypol-containing extract; the second step, washing the gossypol-containing extract with an organic solvent, Discard organic layer, stay water layer; The 3rd step, in the water layer that the 2nd step obtains, add 1 / 3 or 1 / 2 times the diethyl ether of raw material weight and stir, add acid wherein under stirring state, water Adjust the pH value of the layer to 1 or 3, then stir and extract, and after stirring and extracting for 10 minutes or 30 minutes, separate the ether extract A and the extract water layer, extract the extract water layer with ethe...

Embodiment 3

[0034] Embodiment 3: the preparation method of this gossypol acetate is carried out according to the following steps: the first step, with the raw material containing gossypol as raw material, the borate aqueous solution that raw material adopts mass concentration is 1% to 3% at temperature is 10 Extract 2 to 3 times under the condition of ℃ to 60 ℃, combine the extracts, filter the combined extracts to obtain the gossypol-containing extract; the second step, wash the gossypol-containing extract with an organic solvent , discarding the organic layer, leaving the water layer; the third step, adding 1 / 3 to 1 / 2 times the weight of raw material ether to the water layer obtained in the second step and stirring, adding acid thereto under stirring, and Adjust the pH value of the water layer to 1 to 3, then stir and extract, and after stirring and extracting for 10 minutes to 30 minutes, separate the ether extract A and the extracted water layer, extract the extracted water layer with ...

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Abstract

The invention relates to the technical field of gossypol and gossypol acetate, and discloses a preparation method for the gossypol and a preparation method for the gossypol acetate. The preparation method for the gossypol comprises the following steps: extracting; separating and purifying; refining. The purity of the gossypol prepared by the preparation method for the gossypol disclosed by the invention reaches 98.0 to 99.6 percent; on the premise of meeting the requirement on the purity of a gossypol product, the cost of the reagents, such as borax and diethyl ether, used in the preparation method for the gossypol disclosed by the invention is low, and the using amounts of the reagents and the water are small, so that the extracting cost of the preparation method for the gossypol disclosed by the invention is low; meanwhile, the preparation method for the gossypol disclosed by the invention can improve the yield of the gossypol; in addition, the preparation method for the gossypol disclosed by the invention is wide in raw material application range and low in requirements on raw materials, and can treat the gossypol-containing raw materials with complex impurity compositions.

Description

technical field [0001] The invention relates to the technical field of preparation technology of gossypol and gossypol acetate, and relates to a preparation method of gossypol and gossypol acetate. Background technique [0002] Gossypol, also known as gossypol alcohol, is a polyphenolic substance with a chemical name of 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5' -Diisopropyl-2-2'-binaphthyl-8-8'-dialdehyde is a unique secondary metabolite in Malvaceae plants, mainly found in roots, stems, leaves and seeds of cotton Inside, the seed kernel and root bark have higher content. [0003] Gossypol acetate is a complex salt of gossypol and acetic acid, which is more stable than gossypol and is a medicinal form of gossypol. Gossypol and gossypol acetate are mainly used in the field of medicine. They are effective male birth control drugs, have anti-inflammatory and anti-tumor effects, and are used as drugs for the treatment of prostate cancer, gastric cancer, colon cancer and AI...

Claims

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Application Information

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IPC IPC(8): C07C45/78C07C47/57C07C51/41C07C53/10
CPCC07C45/78C07C51/412C07C47/57C07C53/10
Inventor 贾新岳石明辉潘兰陈刚
Owner 新疆维吾尔自治区中药民族药研究所
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