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Use of artemisinin derivatives in the preparation of drugs for the treatment or auxiliary treatment of autoimmune thyroid disease

An autoimmune and thyroid disease technology, applied in allergic diseases, drug combinations, endocrine system diseases, etc., can solve the problem of no research report on the therapeutic effect of artemisinin derivatives in thyroid diseases, and achieve a clear route of administration , good therapeutic effect, easy to accept effect

Active Publication Date: 2021-03-19
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no research report on the therapeutic effect of artemisinin derivatives on autoimmune thyroid disease

Method used

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  • Use of artemisinin derivatives in the preparation of drugs for the treatment or auxiliary treatment of autoimmune thyroid disease
  • Use of artemisinin derivatives in the preparation of drugs for the treatment or auxiliary treatment of autoimmune thyroid disease
  • Use of artemisinin derivatives in the preparation of drugs for the treatment or auxiliary treatment of autoimmune thyroid disease

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Embodiment Construction

[0021] Unless otherwise defined, the technical terms used in the following embodiments have the same meaning as commonly understood by those skilled in the art to which the present invention belongs. The test reagents used in the following examples, unless otherwise specified, are conventional biochemical reagents; the experimental methods, unless otherwise specified, are conventional methods.

[0022] The present invention will be described in detail below in conjunction with examples.

[0023] 1. In the normal group, model group, control group and drug administration group, the test materials used and their sources

[0024] 1. Animals

[0025] Female SPF-grade C57BL / 6 mice, weighing 18-20 g, were purchased from the Experimental Animal Center of the Academy of Military Medical Sciences and raised in an SPF double-corridor barrier environment. All animal experiments were performed in a sterile SPF animal room.

[0026] 2. Main experimental drugs and reagents

[0027] Porci...

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Abstract

The invention provides an application of an artemisinin derivative in preparation of drugs for treatment or adjuvant therapy of an autoimmune thyroid disease. The artemisinin derivative and a pharmaceutical composition thereof are capable of reducing the content of a thyroglobulin antibody (TGAb) and a thyroid peroxidase antibody (TPOAb), and has a relatively good treatment effect on a Graves disease and chronic lymphocytic thyroiditis (hashimoto's thyroiditis and atrophic thyroiditis) or postpartum thyroiditis.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to the use of artemisinin derivatives in the preparation of medicines for the treatment or auxiliary treatment of autoimmune thyroid diseases. Background technique [0002] Artemisinin derivatives have obvious inhibitory effects on animal humoral immunity and cellular immunity, and have been clinically used in the treatment of autoimmune diseases such as lupus erythematosus, and have obtained certain curative effects. [0003] Clinically common autoimmune thyroid diseases include: Graves' disease, chronic lymphatic thyroiditis (Hashimoto's thyroiditis, atrophic thyroiditis), postpartum thyroiditis, etc. Among them, Hashimoto's thyroiditis is the most common thyroid inflammatory disease. The clinical manifestations are diffuse lymphocytic infiltration, fibrosis, interstitial atrophy and eosinophilic changes in acinar cells in the thyroid gland. Multiple factors such a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/366A61K31/357A61K31/541A61P37/02A61P5/14
CPCA61K31/357A61K31/366A61K31/541
Inventor 杨诚周红刚孙涛刘慧娟田勤崔展红秦源李萌
Owner NANKAI UNIV
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