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Method and system for performing orthotopic liver transplantation prognosis condition grouping on hepatocellular carcinoma patient with single tumor

A technology for hepatocellular carcinoma and liver transplantation, applied in the field of precision medicine

Inactive Publication Date: 2017-09-19
冯德昭 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the relationship between the expression of cytokeratin 19 (CK19) or glypican-3 (GPC3) in hepatocellular carcinoma and postoperative tumor metastasis and recurrence has been reported, the combined detection of CK19 or GPC3 has a significant effect on hepatocellular carcinoma. Subclassification and stratification of patient outcomes have not been published

Method used

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  • Method and system for performing orthotopic liver transplantation prognosis condition grouping on hepatocellular carcinoma patient with single tumor
  • Method and system for performing orthotopic liver transplantation prognosis condition grouping on hepatocellular carcinoma patient with single tumor
  • Method and system for performing orthotopic liver transplantation prognosis condition grouping on hepatocellular carcinoma patient with single tumor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Example 1 The grouping method of the present invention is established by identifying risk factors affecting recurrence-free survival of HCC patients after liver transplantation

[0082] 1. Patients and Methods

[0083] Patient and Tissue Samples

[0084] From January 2009 to December 2013, 101 cases of orthotopic liver transplantation were collected from Beijing You'an Hospital Affiliated to Capital Medical University with only one hepatocellular carcinoma nodule. This study complied with the Declaration of Helsinki and was approved by the local ethics committee, and all subjects signed informed consent. All cases had no tumor surgical resection, transcatheter arterial chemoembolization or other chemotherapy, radiotherapy or interventional ablation before operation. Preoperative imaging studies confirmed that all patients had no major vessel tumor invasion, no lymph node or extrahepatic metastases. The selection method of specific research objects is shown in Table...

Embodiment 2

[0121] Example 2 The predictive ability of the model of the present invention to the tumor recurrence after transplantation of hepatocellular carcinoma (technical scheme 1, see for details) with independent validation group test Image 6 ):

[0122] Fifty HCC patients with single tumor nodules were collected from Beijing You'an Hospital, and all patients underwent orthotopic liver transplantation. This group of patients differs from the patient population in Example 1. The tumor diameter data of the patients were obtained from the Department of Medical Imaging, and the results of immunohistochemical staining of CK19 and GPC3 based on liver tumor tissue were obtained from the database of the Department of Pathology (see Table 6 for baseline conditions).

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[0124]

[0125]

[0126]

[0127] The method and system provided by the present invention were used to group the prognosis of patients with hepatocellular carcinoma with a single tumor nodule, wherein the...

Embodiment 3

[0130] Example 3 Prognostic grouping of patients with a single hepatocellular carcinoma nodule based on liver biopsy before orthotopic liver transplantation (technical protocol 2, see Figure 9 ):

[0131] Twenty-seven HCC patients with single tumor nodules were collected from Beijing You'an Hospital. All patients had liver biopsy before orthotopic liver transplantation. The tumor diameter data of the patients were obtained from the Department of Medical Imaging, and the results of immunohistochemical staining of CK19 and GPC3 based on the liver tumor tissue were obtained from the database of the Department of Pathology (see Table 8 for baseline conditions).

[0132] The method and system provided by the present invention are used to group the prognosis of patients with hepatocellular carcinoma with a single tumor nodule, wherein the tumor diameter cut-off value is set to 3.6 cm, and the AFP cut-off value is set to 261.6 ng / mL. It can be found that in the validation set, th...

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Abstract

The invention relates to a method for performing prognosis condition grouping on a hepatocellular carcinoma patient who has single tumor and is about to be subjected to or is already subjected to orthotopic liver transplantation. The method comprises the steps of (1) obtaining a sample from general samples after transhepatic biopsy before transplantation or liver transplantation, and detecting CK19 and GPC3 expression conditions of tumor cells in the hepatocellular carcinoma tissue sample of the patient; (2) detecting and recording a maximum diameter of the tumor of the patient; (3) detecting and recording a serum alpha-fetoprotein level of the patient; and (4) based on a pathological section, observing whether microvascular invasion exists or not. Recurrent risks are scored according to beta coefficients of four factors in COX regression analysis; scores in items are subjected to addition; a recurrent risk group with a total score less than or equal to 4 is determined as a low recurrent risk group; a recurrent risk group with a total score equal to 5-7 is determined as a medium recurrent risk group; and a current risk group with a total score more than or equal to 8 is determined as a high recurrent risk group. Through the method, an effective auxiliary information value can be provided for a doctor and the patient; and tumor recurrence or transfer is closely monitored, so that health conditions can be discovered within the shortest time, the doctor and the patient are effectively prompted, and people are reminded to timely examine body conditions.

Description

technical field [0001] The present invention belongs to the field of precision medicine, and specifically relates to a method and system for analyzing the prognosis of patients with hepatocellular carcinoma (HCC) with a single tumor undergoing orthotopic liver transplantation, through the method and system The results obtained from the implementation of the method can provide intermediate or auxiliary information for the metastasis, recurrence and prediction of the primary tumor after orthotopic liver transplantation in patients with hepatocellular carcinoma. Background technique [0002] Primary liver cancer is one of the malignant tumors with the highest incidence rate in the world, and more than 1 million people are newly diagnosed with this disease every year. [0003] In 1963, Starzl performed the world's first liver transplantation operation for liver cancer and achieved success. Liver transplantation is still recognized as an effective method for the treatment of live...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/00
Inventor 冯德昭冯骥良
Owner 冯德昭
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