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Kidney tonifying and turbidity eliminating Chinese medicine composition and application

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition for nourishing the kidney and removing turbidity, can solve the problem that the effect of the traditional Chinese medicine composition is not very obvious, and achieve the effects of improving insulin resistance and sex hormone levels, the effect is obvious, and the effect of improving ovarian ovulation.

Active Publication Date: 2017-09-08
BEIJING CHINESE MEDICINE HOSPITAL AFFILIATED CAPITAL MEDICAL UNIV
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  • Description
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AI Technical Summary

Problems solved by technology

And the effect of the traditional Chinese medicine composition that is used for the treatment of PCOS-IR in the prior art is not very obvious

Method used

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  • Kidney tonifying and turbidity eliminating Chinese medicine composition and application
  • Kidney tonifying and turbidity eliminating Chinese medicine composition and application
  • Kidney tonifying and turbidity eliminating Chinese medicine composition and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-5

[0036] Table 1.5 Representative Compositions (g) Formulas

[0037]

[0038]

[0039] The preparation method of embodiment 1-5 composition is as follows:

[0040] Proportionally take the Chinese medicinal materials of each component, after pulverization, heat 80 degrees reflux with 8-10 times the dry weight of the raw material to extract twice, each time for 1 hour, combine the extracts, filter, and concentrate under reduced pressure to obtain the extract. The above-mentioned extract is spray-dried, and the yield is 10.2-11.0%. Then adopt dry granulation to obtain the finished composition (infusion).

Embodiment 6

[0041] The functional experiment of the Chinese medicine composition product prepared in embodiment 6. embodiment 5

[0042] 1 Materials and methods

[0043] 1.1 Experimental animals

[0044] Select 72 6-week-old SPF grade SD rats, provided by Beijing Huafukang Biotechnology Co., Ltd., with a body weight of 150-160 g, and randomly divided into: blank group, model group, and high-dose traditional Chinese medicine group (the method of the invention in Example 5). Chinese medicine composition), Chinese medicine medium dose group (Chinese medicine composition of the embodiment 5 of the present invention), Chinese medicine low dose group (Chinese medicine composition of the embodiment 5 of the present invention) and Western medicine metformin group, 12 in each group.

[0045] 1.2 Experimental drugs

[0046] Letrozole (Jiangsu Hengrui Pharmaceutical Co., Ltd., batch number: HI9991001); sodium carmellose (Anhui Shanhe Pharmaceutical Excipients Co., Ltd., batch number: 160301); metf...

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Abstract

The invention discloses a kidney tonifying and turbidity eliminating Chinese medicine composition and application thereof, and belongs to the technical field of pharmaceutical preparations. An active component of the kidney tonifying and turbidity eliminating Chinese medicine composition is prepared from, by weight, herba patriniae, raw coicis semen, talxilli herba, dipsaci radix, raw gypsum, cuscutae semen, poria cocos, pseudostellariae radix, lycopi herba, persicae semen, fructus aurantii and fried licorice root. The kidney tonifying and turbidity eliminating Chinese medicine composition takes kidney tonifying, spleen strengthening, turbidity eliminating and menstruation regulating as therapeutic rules, the fasting insulin level of a PCOS-IR rat can be significantly reduced, endocrine disorder conditions such as hyperandrogenism, LH increasing, abnormal LH / FSH ratios are improved, and polycystic-ovary-like lesions can also be rectified to a certain degree.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a traditional Chinese medicine composition for nourishing the kidney and removing turbidity. Background technique [0002] Polycystic ovary syndrome (PCOS) is a common complex disease of endocrine and metabolic dysfunction in gynecology, characterized by persistent anovulation or rare ovulation, hyperandrogen and / or hyperinsulinemia, and insulin resistance. The main manifestations are oligomenorrhea, amenorrhea, infertility, obesity, hirsutism, acne and so on. Insulin resistance (IR) refers to the metabolic state when the body's physiological level of insulin (Insulin, INS) promotes the absorption and utilization of glucose by organ tissues and cells, and is a pathological change in which the body's target cells respond poorly to normal levels of INS , with high fasting insulin (FINS) levels, normal fasting blood glucose (FPG), insulin resistance index (HOMA-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61K9/16A61P5/50A61P15/08A61K33/06
CPCA61K9/0095A61K9/16A61K33/06A61K36/076A61K36/185A61K36/36A61K36/39A61K36/43A61K36/484A61K36/53A61K36/736A61K36/752A61K36/84A61K36/8994A61K2300/00
Inventor 许昕
Owner BEIJING CHINESE MEDICINE HOSPITAL AFFILIATED CAPITAL MEDICAL UNIV
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