A kind of 3D printing bracket material and its preparation method and application

A technology of 3D printing and scaffold materials, which is applied in the direction of additive processing, prosthesis, tissue regeneration, etc., can solve the problems of precise regulation of the external and internal structures of difficult hydrogels, so as to promote adhesion growth, optimize physical and chemical properties, and promote The effect of bone regeneration

Active Publication Date: 2019-11-26
HOSPITAL OF STOMATOLOGY SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the traditional hydrogel preparation method is mainly through the chemical reaction or physical interaction between polymer chains, and it is difficult to achieve precise regulation of the external and internal structure of the hydrogel.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Example 1 Preparation of 3D printing scaffold material

[0066] The 3D printing scaffold material includes the following components according to the mass concentration: SDF-1 1000 μg / L, BMP 21000 μg / L, sodium alginate 220 mg / L, gelatin 200 mg / L and nano-hydroxyapatite particles 100 mg / L;

[0067] The preparation method of the 3D printing stent material is as follows:

[0068] (1) Dissolve the sodium alginate, gelatin and nano-hydroxyapatite particles in double distilled water according to the formula amount, mix at 37°C, and stir for 3 hours until a uniform transparent solution without precipitation is formed;

[0069] (2) Add SDF-1 and BMP2 to the transparent solution of step (1) according to the formula amount, place it on ice and stir for 30 minutes, pre-cooling at 4°C for use.

[0070] The prepared 3D printing scaffold material adheres well to cells.

Embodiment 2

[0071] Example 2 Preparation of 3D printing scaffold material

[0072] The 3D printing scaffold material includes the following components in mass concentration: SDF-1 900μg / L, BMP2900μg / L, sodium alginate 180mg / L, gelatin 180mg / L and nano-hydroxyapatite particles 80mg / L;

[0073] The preparation method of the 3D printing stent material is as follows:

[0074] (1) Dissolve the sodium alginate, gelatin and nano-hydroxyapatite particles in double distilled water according to the formula amount, mix at 35°C, and stir for 4 hours until a uniform transparent solution without precipitation is formed;

[0075] (2) Add SDF-1 and BMP2 to the transparent solution of step (1) according to the formula amount, place it on ice and stir for 20 minutes, pre-cooled at 4°C for use.

[0076] The prepared 3D printing scaffold material adheres well to cells.

Embodiment 3

[0077] Example 3 Preparation of 3D printing scaffold material

[0078] The 3D printing scaffold material includes the following components by mass concentration: SDF-1 1050μg / L, BMP-21050μg / L, sodium alginate 250mg / L, gelatin 220mg / L and nano-hydroxyapatite particles 120mg / L;

[0079] The preparation method of the 3D printing stent material is as follows:

[0080] (1) Dissolve the sodium alginate, gelatin and nano-hydroxyapatite particles in double distilled water according to the formula amount, mix at 38°C, and stir for 2 hours until a uniform transparent solution without precipitation is formed;

[0081] (2) Add SDF-1 and BMP2 to the transparent solution of step (1) according to the formula amount, place it on ice and stir for 50 minutes, pre-cooled at 4°C for use.

[0082] The prepared 3D printing scaffold material adheres well to cells.

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Abstract

The present invention relates to a 3D printing scaffold material and its preparation method and application, in particular to a 3D printing scaffold material for periodontal tissue reconstruction and its preparation method. The material includes the following components: stromal cell-derived factor-1 (Stromal cell‑derived factor‑1, SDF‑1) and bone morphogenetic proteins 2 (Bone Morphogenetic Proteins, BMPs). The present invention uses two functional molecules, SDF-1 and BMP2, to recruit endogenous stem cells to the periodontal defect area, promote their osteogenic differentiation, and promote periodontal tissue regeneration. At the same time, an individualized bionic degradable polymer scaffold is designed based on 3D printing , Precisely control the external shape and internal microstructure of the material through the computer.

Description

Technical field [0001] The invention relates to the field of materials, in particular to a 3D printing scaffold material and a preparation method and application thereof, and in particular to a 3D printing scaffold material for periodontal and a preparation method thereof. Background technique [0002] Periodontal disease is a chronic infectious disease that destroys tooth support tissues. It is also the main cause of tooth loss in adults. In my country, 80%-97% of adults suffer from different degrees of periodontal disease. The main mechanism of its pathogenesis is the invasion of periodontal tissue by bacteria. Through direct invasion and non-specific immune response of the body, chronic inflammation of periodontal tissue is caused, which in turn causes the destruction of periodontal tissue, especially alveolar bone, and ultimately leads to the loss of supporting tissues. The teeth are loose and fall out. The ultimate goal of periodontal disease treatment is to eliminate the i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/20A61L27/22A61L27/54B33Y10/00B33Y50/02B33Y70/00B33Y80/00
CPCA61L27/12A61L27/20A61L27/222A61L27/54A61L2300/414A61L2300/45A61L2430/12B33Y10/00B33Y50/02B33Y70/00B33Y80/00C08L5/04
Inventor 谭家莉林炯
Owner HOSPITAL OF STOMATOLOGY SUN YAT SEN UNIV
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