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Shikonin-containing band-aid and preparing method thereof

A technology of shikonin and Band-Aid, which is applied in medical formula, medical science, absorbent pads, etc., can solve problems such as health hazards, inability to use open wounds, damage to the liver, etc., achieve non-toxicity, promote wound healing, and reduce scars The effect formed

Inactive Publication Date: 2017-07-21
南京紫源康医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As early as July 6, 2001, the U.S. Drug Administration FDA issued a warning on its official website, requiring manufacturers to stop selling comfrey-containing comfrey for internal use because it can cause harm to human health and even damage the liver. Herbal nutritional supplements should not be used topically on open wounds

Method used

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  • Shikonin-containing band-aid and preparing method thereof
  • Shikonin-containing band-aid and preparing method thereof
  • Shikonin-containing band-aid and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Please refer to figure 1 , a band-aid containing shikonin, consisting of a plain cloth adhesive plaster 1, a water-absorbent pad 2, and a release paper 3, the water-absorbent pad 2 is located in the middle of the plain cloth adhesive plaster 1, and the water-absorbent pad 2 is evenly coated with a A rectangular shikonin mixture, the release paper 3 is covered on the shikonin mixture after drying and volatilization;

[0018] The shikonin mixture is composed of γ-cyclodextrin and shikonin; specifically, it is prepared by embedding 0.01 g of shikonin with γ-cyclodextrin, and specifically shikonin is treated with 1- Dissolve 2 mL of ethyl acetate, mix with 3-5 g of γ-cyclodextrin, concentrate and dry under reduced pressure to form a powder, add 100 mL of water to make a paste, and obtain the shikonin mixture, wherein the mass concentration of shikonin is 0.01% .

[0019] The purification and separation of the shikonin from the comfrey, specifically refer to the relevant m...

Embodiment 2

[0025] All the other structures and preparation method are with embodiment 1:

[0026] Wherein the shikonin mixture is composed of γ-cyclodextrin and shikonin; specifically, it is prepared by embedding shikonin with γ-cyclodextrin, specifically, 0.05 g of shikonin is mixed with 2 Dissolve 3 mL of ethyl acetate, mix with 4-6 g of γ-cyclodextrin, concentrate and dry under reduced pressure to form a powder, add 100 mL of water to make a paste, and obtain the shikonin mixture, wherein the mass concentration of shikonin is 0.05 %.

[0027] The band-aid that embodiment 2 makes is used as treatment group, randomly selects commercially available common band-aid and carries out the clinical trial of the control group, and every group evenly selects 80 cases of the patient's age and the evenly distributed case number of injury symptom degree to carry out the treatment clinical trial of two kinds of band-aid, The three main curative effects of hemostasis and pain relief, anti-inflammato...

Embodiment 3

[0032] All the other structures and preparation method are with embodiment 1:

[0033] The shikonin mixture is composed of γ-cyclodextrin and shikonin; specifically, it is prepared by embedding shikonin with γ-cyclodextrin, specifically, 0.1 g of shikonin is mixed with 3 - Dissolve 4mL of ethyl acetate, mix with 4-8g of γ-cyclodextrin, concentrate and dry under reduced pressure to form a powder, add 100mL of water to make a paste, and obtain the shikonin mixture, wherein the mass concentration of shikonin is 0.1 %.

[0034] The band-aid that embodiment 3 makes is used as treatment group, randomly selects commercially available common band-aid and carries out the clinical trial of the control group, and every group evenly selects 80 examples of the patient's age and the evenly distributed case number of injury symptom degree to carry out the treatment clinical trial of two kinds of band-aid, The three main curative effects of hemostasis and pain relief, anti-inflammatory and a...

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Abstract

The invention discloses a shikonin-containing band-aid and a preparing method thereof. The band-aid is composed of plain-cloth adhesive tape, a water absorption pad and release paper. The water absorption pad is evenly coated with a shikonin mixture, and the shikonin mixture is specially prepared in the mode that shikonin purified and separated from arnebia euchroma is embedded with gamma-cyclodextrin. The band-aid prepared with the method has the functions of a common band-aid, and also has the specific pharmacologic effect of the shikonin, and the effects of resisting bacteria, diminishing inflammation, stopping pains, promoting wound healing, reducing scar forming and the like are enhanced; the preparing method is easy to operate, free of human-body irritation and human-body obvious toxicity and capable of being widely applied to small wound treatment.

Description

technical field [0001] The invention relates to the field of wound medical dressings, in particular to a shikonin-containing band-aid and a preparation method thereof. Background technique [0002] Band-aid is the most commonly used surgical drug in people's life. Band-aid, also known as "hemostatic plaster", has the functions of hemostasis and skin protection. It consists of a long strip of adhesive plaster with a small piece of drug-soaked gauze attached in the middle. Due to its structural limitation, Band-Aid can only be used for emergency treatment of small pieces of trauma, so as to temporarily stop bleeding and protect the wound surface. There are many types of Band-Aids on the market, but most of them are not very effective in stopping bleeding and protecting sores, making it difficult to heal wounds quickly. On the contrary, due to long-term use of Band-Aids, the outer layer of Band-Aids is airtight, and the wound and the skin around the wound will turn white. So...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/20A61L15/44A61L15/46
CPCA61L15/28A61L15/20A61L15/44A61L15/46A61L2300/216A61L2300/404A61L2300/41A61L2300/412A61L2300/62C08L5/16
Inventor 魏元刚孟莲钟慧金显友易铭杨永安
Owner 南京紫源康医药科技有限公司
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