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Liquid control anti-reflux device for microfluidic chip and microfluidic chip

A technology of anti-reflux device and microfluidic chip, which can be used in fluid controllers, laboratory containers, laboratory utensils, etc., and can solve the problem of insufficient flux.

Active Publication Date: 2018-04-03
NANJING LANSION BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This will have a problem that the flux is not large enough

Method used

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  • Liquid control anti-reflux device for microfluidic chip and microfluidic chip
  • Liquid control anti-reflux device for microfluidic chip and microfluidic chip
  • Liquid control anti-reflux device for microfluidic chip and microfluidic chip

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Such as Figure 1-2 As shown, the backflow prevention structure of this embodiment includes a backflow prevention channel 2-d (disposed in the middle chip 2). The extension direction of the backflow prevention channel 2-d and the microflow at the installation position of the backflow prevention structure The extension direction of the flow control channel 3-a (disposed on the lower chip 3) is vertical; the microfluidic flow channel 3-a at the installation position of the backflow prevention structure is divided into two sections by the microfluidic flow channel partition 3-b, They are the microfluidic inlet channel and the microfluidic outlet channel; the upper end of the backflow prevention channel 2-d is closed, and the lower end is connected across the microfluidic channel block 3-b, and is connected to the microfluidic channel respectively. The fluidic inlet channel and the microfluidic outlet channel are connected; when the air channel is connected, the fluid in the ...

Embodiment 2

[0045] Such as Figure 3-4 As shown, the difference between the backflow prevention structure described in this embodiment and Embodiment 1 is:

[0046] 1. The backflow prevention channel 2-d is provided with a backflow prevention protrusion 2-c, and two backflow prevention communication channels 2 are formed between the backflow prevention protrusion 2-c and the backflow prevention flow channel 2-d. b; The two anti-backflow communication channels 2-b are respectively connected with the microfluidic inlet channel and the microfluidic outlet channel; the lower end of the anti-backflow protrusion 2-c and the backflow prevention channel 2 The lower end of -d is flush, and the upper end of the backflow prevention bump 2-c is lower than the upper end of the backflow prevention runner 2-d.

[0047] 2. The upper end closure of the anti-reflux flow channel 2-d is completed by the cover provided by the upper chip 1.

[0048] It can be seen from this that the inventive protruding anti-backflo...

Embodiment 3

[0050] Such as Figure 5-8 As shown, the difference between the backflow prevention structure described in this embodiment and the second embodiment is:

[0051] The microfluidic flow channel spacer 3-b is set as a wedge-shaped block, and the backflow prevention flow channel 2-d is a wedge-shaped groove similar in shape to the microfluidic flow channel spacer 3-b.

[0052] It can be seen from this that since the present embodiment has a convex flow channel, it can significantly prevent backflow.

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Abstract

The invention relates to a back-flow preventer used for controlling liquid of a micro-fluidic chip and the micro-fluidic chip thereof. The back-flow preventer comprises a micro-fluidic channel and a back-flow preventing structure, the back-flow preventing structure is positioned over the micro-fluidic channel and has a back-flow preventing channel; the back-flow preventing channel can lift the liquid level height of the micro-fluidic channel at the installation position of a back-flow preventing structure; when the micro-fluidic channel is connected with the air passage, under driving of air pressure provided by air passage, liquid level height pressure of the micro-fluidic channel which is lifted by the back-flow preventing channel is overcome, and the liquid in the micro-fluidic channel at two sides of the back-flow preventer is urged to a circulation state. The back-flow preventer has good back-flow preventing function.

Description

Technical field [0001] The invention provides a liquid control anti-reflux device for a microfluidic chip and a microfluidic chip containing the reflux device. Background technique [0002] As a stable and practical technology, the immunological lateral chromatography diagnostic technique is suitable for various point-of-care tests (POCT) or on-site use. [0003] In the immune layer reaction system, the CV is large due to system reasons, and accurate quantification cannot be achieved. The immunodiagnostic method based on microfluidic technology can effectively avoid the above problems. [0004] Microfluidics are divided into passive and active types. Passive microfluidics still requires capillary force to achieve liquid forward lateral tomography. However, due to the different viscosity of different samples, especially whole blood samples, the liquid flow rate cannot be uniform. [0005] Active microfluidic control can effectively avoid the above-mentioned problems. It can give for...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00
CPCB01L3/50273B01L3/502746B01L2200/0636B01L2300/089B01L2400/0487
Inventor 许行尚杰弗瑞·陈王龙孙威严万其露
Owner NANJING LANSION BIOTECH CO LTD
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