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Novel biochemical formula effective part and effective component composition and preparation method of composition

A technology of effective parts and active ingredients, applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, organic active ingredients, etc. The effect of low clinical dosage

Inactive Publication Date: 2017-06-13
JIANGSU TIANZHAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional Chinese medicine has a long history of treating gynecological diseases. With the combination of syndrome differentiation and disease identification, traditional Chinese medicine has increasingly shown its unique therapeutic advantages. However, most of the compound medicines for treating dysmenorrhea currently have many prescriptions, large dosages, inconvenient use, and complex ingredients. The effective part is not clear, the material basis for the curative effect in the compound is not clear, and there are some problems such as adverse reactions. Therefore, it is necessary to keep the essence under the guidance of the theory of traditional Chinese medicine, and optimize a drug with a simplified ratio and definite curative effect. , less side effects, easy to take, used for promoting blood circulation and removing blood stasis, regulating menstruation and relieving pain

Method used

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  • Novel biochemical formula effective part and effective component composition and preparation method of composition
  • Novel biochemical formula effective part and effective component composition and preparation method of composition

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Experimental program
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Effect test

Embodiment 1

[0024] Embodiment 1: the preparation of Chinese medicine composition

[0025] Take 300g of motherwort total alkaloids, 150g of safflower total flavonoids, 60g of ligustrazine, 150g of ferulic acid, 60g of amygdalin, 30g of glycyrrhizic acid, 150g of dried ginger total phenols, 30g of liquiritin, and 35 mL of volatile oil of angelica. The volatile oil of Angelica sinensis is clathrated with β-cyclodextrin, the weight ratio is 1:10, the β-cyclodextrin is dissolved in purified water, and the volatile oil solution of Angelica sinensis dissolved in ethanol is slowly added, and clathrated with a high-speed disperser, and the clathrate solution is 10 000 Da molecular weight cut-off ultrafiltration membrane separation, collect the ultrafiltrate, the ultrafiltrate is concentrated by a 100 Da molecular weight cut-off nanofiltration membrane, and the concentrated solution is spray-dried to obtain ligustilide spray-dried powder; motherwort total alkaloids, safflower total Flavonoids, Ligu...

Embodiment 2

[0026] Embodiment 2: the preparation of Chinese medicine composition

[0027] Take 200g of motherwort total alkaloids, 100g of safflower total flavonoids, 50g of ligustrazine, 100g of ferulic acid, 50g of amygdalin, 10g of glycyrrhizic acid, 100g of dry ginger total phenols, 10g of liquiritin, and 10 mL of volatile oil of angelica. The volatile oil of Angelica sinensis is clathrated with β-cyclodextrin, the weight ratio is 1:5, the β-cyclodextrin is dissolved in purified water, and the volatile oil solution of Angelica sinensis dissolved in ethanol is slowly added, clathrated with a high-speed disperser, and the clathrate solution is 20000 The ultrafiltration membrane with a molecular weight cut-off of Da is separated, and the ultrafiltrate is collected. The ultrafiltrate is concentrated by a nanofiltration membrane with a molecular weight cut-off of 300Da. The concentrated solution is spray-dried to obtain a spray-dried powder of ligustilide; , ligustrazine, ferulic acid, amy...

Embodiment 3

[0028] Embodiment 3: the preparation of Chinese medicine composition

[0029] Take 400g total alkaloids of motherwort, 200g total flavonoids of safflower, 100g ligustrazine, 200g ferulic acid, 100g amygdalin, 50g glycyrrhizic acid, 200g total phenols of dried ginger, 50g liquiritin, and 50 mL of volatile oil of angelica. The volatile oil of Angelica sinensis is clathrated with β-cyclodextrin, the weight ratio is 1:20, β-cyclodextrin is dissolved in purified water, and the volatile oil solution of Angelica sinensis dissolved in ethanol is slowly added, and clathrated with a high-speed disperser, and the clathrate solution is 10000 The ultrafiltration membrane with a molecular weight cut-off of Da is separated, and the ultrafiltrate is collected. The ultrafiltrate is concentrated by a nanofiltration membrane with a molecular weight cut-off of 100 Da. The concentrated solution is spray-dried to obtain a spray-dried powder of ligustilide; Flavonoids, ligustrazine, ferulic acid, am...

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Abstract

The invention discloses a novel biochemical formula effective part and effective component composition and a preparation method of the composition. The composition is prepared from, by weight, 20-40 parts of herba leonuri total alkaloids, 10-20 parts of flos carthami total flavonoids, 5-10 parts of ligustrazine, 10-20 parts of ferulic acid, 5-10 parts of amygdalin, 1-5 parts of glycyrrhizic acid, 1-5 parts of radix angelica sinensis volatile oil, 10-20 parts of dry ginger total phenols and 1-5 parts of liquiritin. The provided traditional Chinese medicine composition has the good effects of promoting blood circulating to remove blood stasis, regulating menstruation and stopping pain, and after the medicine flavor is simplified, the clinical medication amount is smaller while the good effects are ensured. The preparation method of the traditional Chinese medicine composition effectively avoids effective part and effective component precipitation loss caused when acidic and alkaline components form a compound in the decocting process of a traditional Chinese medicine decoction, and reasonable utilization of traditional Chinese medicine resources is achieved while the medicine treatment effects are guaranteed.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a traditional Chinese medicine composition capable of promoting blood circulation, removing blood stasis, regulating menstruation and relieving pain, in particular to a composition of effective parts and active ingredients of Xinshenghuafang and a preparation method thereof. Background technique [0002] Dysmenorrhea is one of the most common symptoms in gynecology, and about 75% of women have dysmenorrhea. Dysmenorrhea is divided into two categories: primary and secondary. Primary dysmenorrhea refers to cramping pain in the lower abdomen and waist before and during menstruation, accompanied by nausea, vomiting, and cold extremities in severe cases, especially in unmarried young women. . Traditional Chinese medicine has a long history of treating gynecological diseases. With the combination of syndrome differentiation and disease identification, traditional Chinese medicine has increasingl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K47/69A61P15/00A61P29/00A61K31/192A61K31/4965A61K31/7028A61K31/704A61K31/7048
Inventor 黄胜良彭国平辛小娜李存玉吴建雄孙大正
Owner JIANGSU TIANZHAO PHARMA
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