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Application of red beet as edible plant source nitric oxide replenisher

A technology of nitric oxide and red beet, applied in the directions of plant raw materials, plant/algae/fungus/moss ingredients, anti-inflammatory agents, etc., can solve the problems of low content and no development value, etc., to reduce high blood pressure, improve Vascular endothelial function and the effect of enhancing exercise endurance

Inactive Publication Date: 2017-05-31
得力奥(广州)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of them do not have further development value because the content is not high.

Method used

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  • Application of red beet as edible plant source nitric oxide replenisher
  • Application of red beet as edible plant source nitric oxide replenisher
  • Application of red beet as edible plant source nitric oxide replenisher

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Separation of red beet nitro compounds

[0038] Red beets are medium-sized (such as figure 1 , each with a wet weight of about 200-300 grams). Through the quantitative determination of fresh red beet, it was found that red beet roots, stems, and leaves all have high levels of nitro compounds that can be converted into nitric oxide ( figure 2 , with nitro NO3- as the conversion unit), among which, the root content is the highest, and it is significantly higher than that of fresh American ginseng (commonly known as American ginseng) produced in Wisconsin, USA ( figure 2 ); after drying red beets, red beetroots were found to contain higher levels of nitro compounds that can be converted to nitric oxide ( image 3 ).

[0039] The separation process of nitro compounds in red beet: dry or fresh red beet with 20,000g of plastic balls, crushed for 2 minutes, add pure water, centrifuge at 10,000g for 2 minutes, the supernatant of dissolved water is rich in nitro ...

Embodiment 2

[0044] Example 2 Application of isolated nitro compounds to reduce high blood pressure

[0045] After drinking red beet juice to volunteers with hypertension for about 1 to 2 hours, the blood pressure of the volunteers began to drop steadily, and the heart rate did not change significantly ( Figure 6 ), and this benefit can last for a long time. Volunteers were monitored drinking red beet juice containing 300 mg of nitric oxide donors. Blood pressure began to drop within an hour. 6 to 9 hours blood pressure reached the maximum drop. This antihypertensive effect can last for about 12 hours. This is consistent with the metabolism of nitric oxide donors in vivo.

[0046] Nitric oxide donors also reach peak absorption in 6-9 hours ( Figure 7 ). In order to achieve a better antihypertensive effect, drinking twice a day (every 12 hours) is a better way. Based on the results, the inventors deduced that the effect should be the result of the relaxation of vascular smooth musc...

Embodiment 3

[0048] Example 3 Application of isolated decolorized red beet juice (colorless nitro compound) to study the effect on blood pressure

[0049] Since the inventor has proved through a series of experiments that the nitro compound of red beet is a colorless multi-molecular complex, the effect of decolorized red beet juice on blood pressure was further observed. Red beet juice has two absorption spectra, yellow-green at 480 nm and magenta at 540 nm. After activated carbon decolorization, at least 95% of the pigment has been removed ( Figure 8 A). Nitric oxide donor levels were measured and 300 mg administered to hypertensive volunteers. Observe the changes in blood pressure within 12 hours. Similarly decolorized red beet juice lowered blood pressure similarly to application of red beet juice ( Figure 8 B). This set of data fully demonstrated that the nitric oxide donors with antihypertensive effect in red beet are multi-component colorless nitro compounds.

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Abstract

The invention provides application of red beet as an edible plant source nitric oxide replenisher. Nitrocompounds in red beet are all soluble in water and can be effectively converted into nitric oxide in the human body. The edible nitric oxide replenisher can generate nitric oxide without mitochondria aldehyde dehydrogenase and generate the transition product nitrous acid group through salivary gland nitrate reductase, and the nitrous acid group enters a blood circulation system and is converted into nitric oxide in a hypoxia area of endothelium. The nitrocompound group has a remarkable cardiovascular health improving effect. After Chinese people whose acetaldehyde dehydrogenase genes have R671 polymeric morphism (G / A) drink red beet juice, hypertension can be effectively relieved, and the vascular endothelial function can be effectively improved. Nitric oxide is an active molecule with multiple functions. Besides the cardiovascular health improving effect, nitric oxide can also resist inflammation, improve oxygen supply, improve blood flow and enhance exercise tolerance. Therefore, red beet products have an extensive and practical development and application value.

Description

technical field [0001] The invention relates to the technical field of application of health-care medicines, and more specifically relates to the application of red beet as an edible plant source nitric oxide supplement. Background technique [0002] Since NO was discovered in 1980 as a signal molecule in the human body, people have conducted in-depth and extensive research on it. NO acts as a messenger molecule. When the endothelium wants to send a signal to the muscles to increase blood flow, it produces NO molecules, which are small enough to pass easily through the cell membrane. The smooth muscle cells around the blood vessels receive the signal and relax, causing vasodilation. After long-term scientific exploration and research, pharmaceutical development and medical clinical application have proved that NO is a direct and effective active molecule that induces vasodilation, and has the effect of improving cardiovascular and cerebrovascular effects. In addition, NO, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P43/00A61P9/12A61P9/00A61P29/00
CPCA61K36/185A61K2236/31
Inventor 郭长江王宏安德鲁·高
Owner 得力奥(广州)生物科技有限公司
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