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Early prediction marker for gestational diabetes mellitus and detection method thereof

A technology of markers and diabetes, which is applied in the direction of biological testing, material inspection products, etc., can solve the problems of not being able to predict markers of gestational diabetes, and achieve the effects of avoiding adverse effects, high prediction accuracy, and simple operation

Inactive Publication Date: 2017-05-24
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above deficiencies in the prior art, the purpose of the present invention is to provide a marker for early prediction of gestational diabetes and its detection method, aiming to solve the problem that there is no marker capable of predicting gestational diabetes in the prior art

Method used

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  • Early prediction marker for gestational diabetes mellitus and detection method thereof
  • Early prediction marker for gestational diabetes mellitus and detection method thereof
  • Early prediction marker for gestational diabetes mellitus and detection method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The serum samples of target 1 were collected at 12-16 weeks of pregnancy, and the serum samples of patients with gestational diabetes mellitus and healthy controls were compared and analyzed by high-throughput proteomics method and enzyme-linked immunosorbent technology. The results were obtained: Compared with the serum of healthy pregnant women, 33 serum differential proteins were obtained in the serum of patients with gestational diabetes, of which 14 expressed proteins were up-regulated and 19 expressed proteins were down-regulated, see Table 1 below for details.

[0022] Table 1 Comparison table of serum differential protein between target 1 and healthy pregnant women in early pregnancy (12-16 weeks)

[0023]

[0024]

Embodiment 2

[0026] The serum samples of target 2 were collected at 12-16 weeks of gestation, and the serum samples of patients with gestational diabetes mellitus and healthy controls were compared and analyzed by high-throughput proteomics method. The results were obtained: Compared with the serum of healthy pregnant women, 3 serum differential proteins were obtained in the serum of patients with gestational diabetes mellitus, of which 2 expressed proteins were up-regulated and 1 expressed protein was down-regulated, as shown in Table 2 below.

[0027] Table 2 Comparison table of serum differential protein between target 2 and healthy pregnant women in early pregnancy (12-16 weeks)

[0028]

Embodiment 3

[0030] The serum samples of target 3 were collected at 12-16 weeks of pregnancy, and the serum samples of patients with gestational diabetes mellitus and healthy controls were compared and analyzed by enzyme-linked immunosorbent immunoassay and protein chip technology. The results were obtained: Compared with the serum of healthy pregnant women, 4 serum differential proteins were obtained in the serum of patients with gestational diabetes mellitus, of which 2 expressed proteins were up-regulated and 2 expressed proteins were down-regulated, see Table 3 below for details.

[0031] Table 3 Comparison Table of Serum Difference Protein between Target 3 and Healthy Pregnant Women in Early Pregnancy (12-16 Weeks)

[0032]

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Abstract

The invention provides an early prediction marker for gestational diabetes mellitus and a detection method thereof. The marker is serum differential protein which comprises 33 proteins including fat plasma membrane related protein, antithrombin-III, apolipoprotein A5, apolipoprotein E and the like; the concentration change of the serum differential protein is detected by one or more of a high-throughput proteomics method, an enzyme linked immunosorbent assay technology and a protein chip technology so as to predict whether a to-be-detected object in the 12th-16th week of pregnancy is to suffer from gestational diabetes mellitus in the 24th-28th weeks of pregnancy; the prediction accuracy of the marker is high; and the detection method is simple to operate and can assist in early diagnosis of potential patients suffering from gestational diabetes mellitus so as to avoid adverse impacts of the disease on the health of patients and fetuses thereof.

Description

technical field [0001] The invention relates to the technical field of biological detection, in particular to an early predictive marker for gestational diabetes and a detection method thereof. Background technique [0002] Gestational diabetes mellitus (GDM) is abnormal glucose metabolism in varying degrees during pregnancy, and is one of the most common complications during pregnancy, often accompanied by preeclampsia, macrosomia, fetal malformation, and perinatal death It is closely related to metabolic syndrome in offspring and type 2 diabetes in mother after delivery. The etiology of the disease has not been elucidated so far, and the incidence rate increases gradually, causing serious harm to the health of mothers and infants. [0003] At present, the time of clinical diagnosis of gestational diabetes mellitus is 24-28 weeks of gestation, which is determined by 75g glucose tolerance test (glucose tolerance test, OGTT). However, clinical practice shows that when the d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/68
Inventor 沈立明赵丹青
Owner SHENZHEN UNIV
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