Composite traditional Chinese medicine lozenge as well as preparation method and application thereof

A technology of compound traditional Chinese medicine and traditional Chinese medicine, which is applied in the direction of medical preparations containing active ingredients, drug combinations, and medical formulas, and can solve the problems of inconvenient carrying, storage, and taking of mixtures, easy drug resistance, and poor overall effect. Achieve the effect of being easy to carry and take, avoiding drug resistance, and improving taste

Active Publication Date: 2017-05-24
LUNAN HOPE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Zhong Daihua et al. studied the preliminary pharmacodynamics of the Erding mixture composed of Viola Didin and Dandelion and other traditional Chinese medicines, showing that it has obvious anti-inflammatory and antibacterial effects (Zhong Daihua, Zhang Li, Jiang Yu, etc. Erding Preliminary pharmacodynamic study of the mixture [J]. Chongqing Chinese Herbal Medicine Research, 1999, 39: 37-38), but the mixture is inconvenient to carry, store and take
[0006] At present, from the perspective of clinical medication, western medicine is generally antibacterial and anti-inflammatory, and antibiotics are mostly used in drugs, but the overall effect is not good, drug resistance is easy to develop, toxic and side effects are large, and it is easy to cause antibiotic abuse, resulting in bacterial flora imbalance in the body. People are paying more and more attention to treating pharyngitis with traditional Chinese medicine

Method used

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  • Composite traditional Chinese medicine lozenge as well as preparation method and application thereof
  • Composite traditional Chinese medicine lozenge as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Effect Test on Rat Acute Pharyngitis Model

[0036] 1. Test material

[0037] Samples: Viola dicarpa extract and Dandelion extract prepared by the process described in Best Example 11 were used as test samples, and a uniform suspension was prepared with 0.5% sodium carboxymethylcellulose solution. Positive control drug: Golden Throat Lozenges.

[0038] Animals and grouping: Wistar rats were divided into normal control group, model control group, positive control group and Example 1 group. Pharyngeal spray administration, the dosage of Example 1 group is 76 mg / kg / d of viola extract + 38 mg / kg / d of dandelion extract, and the dosage of the positive control group is 926 mg / kg / d.

[0039] Instruments: electronic scales, ultra-clean bench, magnetic stirrer.

[0040] 2. Test method

[0041] After the rat was fixed with a spatula, 15% ammonia solution was sprayed in the throat of the rat; 0.5ml was sprayed each time, once a day at 9:00, 13:00, and 16:00, for 4 conse...

Embodiment 2

[0055] Example 2 Effect Test on Rabbit Chronic Pharyngitis Model

[0056] 1. Test material

[0057] Samples: Viola dicarpa extract and Dandelion extract prepared by the process described in Best Example 11 were used as test samples, and a uniform suspension was prepared with 0.5% sodium carboxymethylcellulose solution. Positive control drug: Erding Granules.

[0058] Animals and grouping: Japanese big-eared white rabbits, divided into normal control group, model control group, positive control group and Example 1. Pharyngeal spray administration, the dosage of the embodiment 1 group is viola chinensis extract 43.4mg / kg / d+dandelion extract 21.7mg / kg / d, and the dosage of the positive control group is 2657.3mg / kg / d .

[0059] Instruments: electronic scales, ultra-clean bench, magnetic stirrer.

[0060] 2. Test method

[0061] Modeling was made according to Peng's modeling method, that is, after the tongue was fixed with a tongue depressor, 2.5% ammonia solution was sprayed o...

Embodiment 3

[0072] The preparation of embodiment 3 compound Chinese medicine buccal tablets

[0073] 1) Preparation of the extract of Viola chinensis: take the medicinal material of Viola chinensis, add 14 times and 10 times the amount of 80% ethanol, heat and reflux extraction twice, each time for 1 hour, filter, combine the filtrates, and recover the ethanol under reduced pressure And concentrated to the amount of medicinal materials, centrifuged, the centrifugate was added to the treated HPD-826 macroporous adsorption resin column at a flow rate of 0.5BV / h, first eluted with 3BV water at a flow rate of 3BV / h, and then sequentially washed with 2BV 30 % and 2BV 60% ethanol were eluted at a flow rate of 2BV / h, the corresponding alcohol eluent was collected, the ethanol was recovered, concentrated into a thick paste with a relative density of 1.25-1.30, and vacuum-dried at 80°C and a vacuum degree greater than 0.8Mpa. Smash, that is.

[0074] 2) Preparation of dandelion extract: Take dand...

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PUM

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Abstract

The invention discloses a composite traditional Chinese medicine lozenge which has effects of clearing away heat and toxic materials and relieving swelling and stopping pain, as well as a preparation method and application thereof, and belongs to the field of traditional Chinese medicine preparations. The composite traditional Chinese medicine lozenge consists of the following components in percentage by weight: 4-10% of a Chinese violet extract, 1-5% of a dandelion extract and 85-95% of medicinal auxiliary materials. The invention further discloses a method for preparing the composite traditional Chinese medicine lozenge. The method comprises main processes of preparing the Chinese violet extract, preparing the dandelion extract and preparing the composite traditional Chinese medicine lozenge. In addition, the invention further discloses application of the composite traditional Chinese medicine lozenge in preparing a medicine for treating pharyngitis. Compared with a preparation for treating pharyngitis in the market, the composite traditional Chinese medicine lozenge disclosed by the invention is concise and special in medicinal effect, can treat both symptoms and root causes and is good in specificity as the medicine is retained at focuses of throats for a long time and the medicinal effects can be brought into play rapidly and continuously; meanwhile, by adopting the oral lozenge, the first pass effect of livers can be avoided, and the bioavailability can be high.

Description

technical field [0001] The invention relates to a compound traditional Chinese medicine buccal tablet with functions of clearing heat, detoxifying, reducing swelling and relieving pain, a preparation method and application thereof, and belongs to the field of traditional Chinese medicines. Background technique [0002] Pharyngitis belongs to the category of "throat numbness" in traditional Chinese medicine. Sore throat refers to a pharyngeal disease characterized by sore throat or foreign body discomfort, redness and swelling of the pharynx, or granular protrusions at the bottom of the larynx. Because the etiology and pathology of this disease can be divided into wind-heat and yin-deficiency, the sore throat caused by wind-heat evil poison is called "wind-heat sore throat", and the sore throat caused by loss of viscera and deficiency fire is called "wind-heat sore throat". Deficiency fire throat numbness ". [0003] Wind-heat sore throat, often due to rapid changes in clim...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/86A61K9/20A61P11/04
Inventor 张贵民张则平孙宗喜乔建卫冯倩武光云
Owner LUNAN HOPE PHARM CO LTD
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