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Application of miR-342-5p in preparation of drug for preventing and treating heart disease

A heart disease and drug technology, applied in the field of biomedicine, can solve the problems of poor efficacy in patients with myocardial insulin resistance, achieve the effects of reducing myocardial ischemia/reperfusion injury, improving cardiac function, and significant cardioprotection

Active Publication Date: 2017-05-24
FOURTH MILITARY MEDICAL UNIVERSITY
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Problems solved by technology

However, the application of polarizing fluid is facing more and more challenges, because there are more and more patients with coronary heart disease and diabetes, and its effect on patients with myocardial insulin resistance is not good.

Method used

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  • Application of miR-342-5p in preparation of drug for preventing and treating heart disease
  • Application of miR-342-5p in preparation of drug for preventing and treating heart disease
  • Application of miR-342-5p in preparation of drug for preventing and treating heart disease

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Embodiment Construction

[0026] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0027] miR-342-5p is a kind of miRNA whose sequence is: GAGUUAGUGUCUAUCGUGGGGA. The present invention finds that miR-342-5p has a significant cardioprotective effect through the following research and can reduce myocardial ischemia / reperfusion injury, which can be applied to prevent and treat heart disease medicine.

[0028] 1) Inhibition of miR-342-5p on cardiac ischemia / reperfusion (I / R) injury in vivo

[0029] The 6-week-old male SD rats were randomly divided into two groups, the experimental group (I / R+miR-342-5p) was injected with miR-342-5p agomir (10nmol) at the myocardial point, and the control group (I / R) was injected with the myocardial point its contrast reagent. After 48 hours, the myocardial ischemia-reperfusion model was established. Under the condition of 3% pentobarbital so...

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Abstract

The invention discloses application of miR-342-5p in the preparation of a drug for preventing and treating heart disease. MiR-342-5p has a significant cardioprotective effect, can reduce myocardial ischemia / reperfusion injuries and can improve cardiac function. MiR-342-5p is an endogenous substance existing in normal cardiomyocytes, so that MiR-342-5p is regulated to prevent and treat the heart disease in safety advantage. MiR-342-5p plays a role of cardioprotection by down-regulating the apoptosis-related proteins caspase9 and JNK2 and activating a cardiomyocyte survival signal, and has many target spots and a good comprehensive effect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to the application of miR-342-5p in the preparation of drugs for preventing and treating heart disease. Background technique [0002] Coronary heart disease is the number one killer of human beings and brings serious medical and economic burdens to society. The main pathological mechanism of coronary heart disease harming the heart is myocardial ischemia / reperfusion injury after acute coronary artery obstruction. During myocardial ischemia, cardiomyocyte energy metabolism is impaired, ATP production decreases, ROS and cytoplasmic free Ca 2+ increased; during reperfusion, ROS and cytoplasmic free Ca 2+ Further increase, activation of protease, aggravation of mitochondrial damage and activation of apoptosis pathway lead to apoptosis and necrosis of cardiomyocytes and affect cardiac function. Current interventional surgery plays an important role in restoring myocardial blood suppl...

Claims

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Application Information

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IPC IPC(8): A61K31/711A61K48/00A61P9/10A61P9/00
CPCA61K31/711
Inventor 高峰侯作旭王立锋秦兴华张星
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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