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Compound reserpine tablet for treating hypertension and preparation method thereof

A compound reserpine and high blood pressure technology, which is applied to chemical instruments and methods, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the problems of unsteady dissolution and other problems, and achieve low stirring efficiency and good use stability , strong applicability

Inactive Publication Date: 2017-05-10
南京康凯生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing Compound Reserpine Tablets adopts dry compression process or adopts methods such as inclusion to increase the stability of the preparation, the dissolution is unstable, and clinically patients often have some side effects when taking it

Method used

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  • Compound reserpine tablet for treating hypertension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Weigh 3.2 parts of reserpine, 310 parts of hydrochlorothiazide, 100 parts of vitamin B6, 100 parts of calcium pantothenate, 300 parts of magnesium trisilicate, 300 parts of potassium chloride, 100 parts of vitamin B1, 420 parts of dihydralazine sulfate, 210 parts of promethazine hydrochloride, 25 parts of ethyl cellulose, 35 parts of corn starch, 15 parts of sodium starch glycolate, and 2 parts of magnesium stearate, take the above-mentioned raw materials and auxiliary materials and put them in a crushing equipment for crushing; Mix evenly, granulate according to conventional methods, compress into tablets, and pack to obtain finished products.

[0017] Particle mixers above, see figure 1 , including a base 1, a mixing cylinder 2 arranged on the base 1, a stirring motor 3 is arranged in the base 1, the main shaft of the stirring motor 3 is in contact with the center of the bottom wall of the mixing cylinder 2 Connected, the bottom wall in the mixing cylinder 2 is provi...

Embodiment 3

[0023] Example 3 Research on the Release of Compound Reserpine Tablets

[0024] Get respectively the tablet that the embodiment of the present invention 1, comparative example 2 prepare, according to the release assay method [2005 version 5 Chinese Pharmacopoeia (two) appendix XD first method], with 0.5% sodium lauryl sulfate solution 1000mL As a solvent, the rotation speed is 50r / min. Operate according to the law. Take 10mL of the solution at 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, and 24h, filter, and replenish 10mL of the above solvent in time Get continued filtrate, measure absorbance at 274nm wavelength according to spectrophotometry (2005 edition 5 Chinese Pharmacopoeia (two) appendix IVA); In addition, accurately weigh the amount of reserpine reference substance that is dried at 105 degrees for 2h, add 0.5% ten The dialkyl sodium sulfate solution was heated and sonicated to dissolve and quantitatively diluted to a solution containing 10ug of drug per 1mL. The absorbance...

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Abstract

The invention relates to a compound reserpine tablet for treating hypertension and belongs to the technical field of Western medicine preparation. The compound reserpine tablet is composed of the following components: 3.2 parts of reserpine, 310 parts of hydrochlorothiazide, 100 parts of vitamin B6, 100 parts of mixed spiral calcium pantothenate, 300 parts of magnesium trisilicate, 300 parts of potassium chloride, 100 parts of vitamin B1, 420 parts of dihydralazine sulfate and 210 parts of promethazine hydrochloride. A specific grain mixer is adopted for mixing. The tablet provided by the invention is slowly and stably released.

Description

technical field [0001] The invention belongs to the technical field of western medicine preparations, in particular to a compound reserpine tablet for treating hypertension. Background technique [0002] Compound Reserpine Tablets are indicated for early and mid-stage hypertension. Existing compound reserpine tablets adopt dry compression process or adopt methods such as inclusion to increase the stability of the preparation, the dissolution is unstable, and clinically patients often have some side effects when taking it. Contents of the invention [0003] In order to overcome the deficiencies of the prior art, the present invention provides a compound reserpine tablet through a large number of tests on auxiliary material screening, process optimization and equipment improvement. The tablet is sustained-release, has small gastrointestinal side effects, and has a simple preparation process. [0004] The purpose of the present invention is achieved like this: [0005] A c...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K9/20A61P9/12B01F7/16A61K31/475A61K31/549A61K31/4415A61K31/197A61K31/51A61K31/502A61K31/5415
CPCA61K9/2059A61K31/197A61K31/4415A61K31/475A61K31/502A61K31/51A61K31/5415A61K31/549A61K33/14B01F27/191B01F27/85A61K2300/00
Inventor 时贞平
Owner 南京康凯生物科技有限公司
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