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Compound ceftiofur cream and preparation method thereof

A technology of thiifur cream and ceftiofur hydrochloride, which is applied in the directions of ointment delivery, pharmaceutical formulation, aerosol delivery, etc., can solve the problems of limited types of injections, ointment is not included, etc., and achieves stable properties and low resistance rate , the effect of fast action

Inactive Publication Date: 2017-04-26
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The introduction of ceftiofur hydrochloride and lincomycin hydrochloride in my country and the research on their preparations are relatively late, and they are all researched on the single preparation of lincomycin hydrochloride and ceftiofur hydrochloride, which are the types of injections approved by the Ministry of Agriculture for production and sales More limited and does not include creams

Method used

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  • Compound ceftiofur cream and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 100g of compound cream containing ceftiofur hydrochloride and lincomycin hydrochloride, consisting of the following ingredients in percentage by weight: ceftiofur hydrochloride 1g, lincomycin hydrochloride 0.5g, stearic acid 6g, monostearic acid Glycerides 13g, Lanolin 3g, Liquid Paraffin 40.0g, White Vaseline 12g, Span 805g, Tween 802g, Poloxamer 0.1g, Glycerin 1g, Propylene Glycol 2g, Vitamin E 0.1g, Ethyl Paraben 0.08g , Purified water is added to 100g.

[0037] The preparation steps are:

[0038] A: Mixed micronized powder: Micronized ceftiofur hydrochloride and lincomycin hydrochloride, passed through a 200 mesh sieve, and mixed well.

[0039] B: Preparation of oil phase: take stearic acid, glyceryl monostearate, lanolin, liquid paraffin, white petrolatum, Span 80, stir at 700r / min, and heat to melt at 60°C in a water bath.

[0040] C: Water phase preparation: Disperse the solid of step A uniformly in glycerin and propylene glycol, and then dissolve the above solution wit...

Embodiment 2

[0043] 100g of a compound cream containing ceftiofur hydrochloride and lincomycin hydrochloride, consisting of the following ingredients in percent by weight: ceftiofur hydrochloride 2.4g, lincomycin hydrochloride 1.2g, stearic acid 9g, monostearic acid Acid glycerides 14g, lanolin 4g, liquid paraffin 20.0g, white petrolatum 5g, spar 803g, Tween 802.5g, poloxamer 0.08g, glycerol 1.5g, propylene glycol 1.3g, vitamin E 0.05g, bisulfite Sodium 0.07g, ethyl paraben 0.06g, sodium benzoate 0.06g, purified water is added to 100g.

[0044] The preparation steps are:

[0045] A: Mixed micronized powder: Micronized ceftiofur hydrochloride and lincomycin hydrochloride, passed through a 300-mesh sieve, and mixed well.

[0046] B: Preparation of oil phase: Take stearic acid, glyceryl monostearate, lanolin, liquid paraffin, white petrolatum, and Span 80 in a container, stir at 900r / min, and heat to melt at 70°C in a water bath.

[0047] C: Preparation of water phase: disperse the solid of step A u...

Embodiment 3

[0050] 100g of a compound cream containing ceftiofur hydrochloride and lincomycin hydrochloride, consisting of the following ingredients in percentages by weight: ceftiofur hydrochloride 1.8g, lincomycin hydrochloride 0.9g, stearic acid 10g, monostearic acid Acid glycerides 16g, lanolin 3.5g, liquid paraffin 30.0g, white petrolatum 10g, span 803.5g, Tween 801.5g, poloxamer 0.06g, sodium lauryl sulfate 0.09g, glycerol 2.5g, propylene glycol 1.6g, vitamin E 0.06g, ethyl paraben 0.07g, sodium benzoate 0.05g, purified water to 100g.

[0051] The preparation steps are:

[0052] A: Mixed micronized powder: Micronized ceftiofur hydrochloride and lincomycin hydrochloride, passed through a 200-mesh sieve, and mixed well.

[0053] B: Oil phase configuration: Take liquid stearic acid, glyceryl monostearate, lanolin, paraffin, white petrolatum, and Span 80 into a container, stir at 900r / min, and heat to melt at 80°C in a water bath.

[0054] C: Water phase configuration: disperse the solid of st...

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Abstract

The present invention relates to a ceftiofur hydrochloride and lincomycin hydrochloride compound cream and a preparation method thereof, wherein the cream comprises ceftiofur hydrochloride, lincomycin hydrochloride and other suitable materials, and during the preparation, a water phase and an oil phase are prepared, then the water phase is added to the oil phase to prepare a cream, and sterilization is performed.

Description

Technical field [0001] The invention belongs to the field of veterinary drug preparations, and particularly relates to a compound cream containing ceftiofur hydrochloride and lincomycin hydrochloride and a preparation method thereof. Background technique [0002] Cow mastitis is a disease of breast tissue and mastitis caused by pathogenic microorganisms and other factors. Nowadays, there are about 230 million dairy cows in the world, and about 1 / 3 of them suffer from various types of mastitis, and the annual loss due to mastitis is as high as 300 billion yuan. In my country, the positive rate of dairy cow mastitis is as high as 50% to 70%, and the economic loss is about 135 million yuan. Therefore, mastitis has become the most common veterinary clinic, and it is also the most harmful disease for dairy cow production. At present, the treatment methods for dairy cow mastitis include Chinese herbal medicine treatment or antibiotic treatment, that is, systemic treatment with large ...

Claims

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Application Information

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IPC IPC(8): A61K31/7056A61K9/06A61P31/04A61P31/02A61K31/546
Inventor 郑超李旭东刘爱玲井丁丁刘桂兰
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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