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Preparation method of long-acting mosquito repellent liquid and long-acting mosquito repellent liquid

A production method and technology for mosquito repellent are applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., and can solve the problems of short duration of mosquito repellent and side effects.

Inactive Publication Date: 2017-04-26
东莞小猕猴户外用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The prior art has the problems of side effects and short mosquito repellent time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The preparation method of long-acting mosquito repellent liquid is made by the following steps:

[0020] Get 5 parts by weight of hydroxyethyl piperidine carboxylate isobutyl ester and add in the water of 20 parts by weight to obtain the first solution, the structural formula of hydroxyethyl piperidine carboxylate isobutyl ester is:

[0021] Get 5 parts by weight of lemon eucalyptus oil and add in 20 parts by weight of ethanol to obtain the second solution;

[0022] mixing the first solution with the second solution to obtain a third solution;

[0023] Take 20 parts by weight of Pelargonium geranium and 10 parts by weight of leaves of Artemisia argyi. The water content of geranium geranium and leaf wormwood is not more than 30%. Parts of ethanol aqueous solution, the ethanol aqueous solution is 75% ethanol aqueous solution (v / v), reflux extraction at a constant temperature of 30-40°C and 0.15MPa for 3-4 hours to obtain the fourth solution; heat the fourth solution A...

Embodiment 2

[0028] A long-acting mosquito repellent prepared by any one of the above-mentioned long-acting mosquito repellent preparation methods.

Embodiment 3

[0030] Rat acute oral toxicity test.

[0031] Test sample: Add water to 6 g of the long-acting mosquito repellent solution of Example 1 to 12 mL and mix thoroughly, as a test sample.

[0032] Experimental animals: Wistar rats with a body weight of 160-200 g, 3 males and 3 males in total, 6 Wistar rats, which have been adapted to the laboratory for more than 2 days and have no abnormal health status, are selected.

[0033] Test method: Animals were fasted overnight, and 2ml / only was orally gavaged, observed and recorded the symptoms after gavage, observed continuously for two weeks, and calculated the median lethal dose (LD 50 ).

[0034] Experimental results: No obvious symptoms of poisoning, no deaths. The median lethal dose was not measured, or the acute oral median lethal dose in rats was greater than 5000 mg / kg for males and females.

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PUM

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Abstract

The invention provides a preparation method of long-acting mosquito repellent liquid. The long-acting mosquito repellent liquid is prepared by taking 3-8 parts by weight of hydroxyethyl isobutyl piperidine carboxylate in 20 parts by weight of water to obtain a first solution; and taking 3-8 parts by weight of citriodora oil and adding to 20 parts by weight of ethano to obtain a second solution; mixing the first solution and the second solution to obtain the third solution; taking 10-20 parts by weight of pelargonium roseum ait, and 10-20 parts by weight of folium artemisiae argyi to 100 parts by weight of ethanol water solution; performing backflow and extraction for 3-4 hours under constant temperature of 30-40 DEG C and pressure of 0.15 MPa to obtain a fourth solution; concentrating the fourth solution to 4-50 parts by weight of solution and mixing with the third solution; adding 0-0.5 part by weight of citric acid. The invention further provides the long-acting mosquito repellent liquid. The long-acting mosquito repellent liquid is free from side effect and long-acting mosquito repellent effect at the same time.

Description

technical field [0001] The invention belongs to the technical field of outdoor products, and in particular relates to a method for making an outdoor long-acting mosquito repellent and the long-acting mosquito repellent. Background technique [0002] Mosquitoes can not only bring people annoying itching, but if the itching is not handled properly, it may turn into indelible scars, which will affect the appearance of people's skin for a long time, and the main harm of mosquitoes is to spread diseases. According to relevant studies, there are more than 80 kinds of diseases transmitted by mosquitoes. [0003] One solution is to keep mosquitoes from touching human skin through isolation. [0004] The prior art has the problems of side effects and short mosquito repelling time. Contents of the invention [0005] One of the objects of the present invention is to provide a method for making a long-acting mosquito repellent liquid without side effects. This purpose is achieved t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/92A61K8/49A61K8/365A61Q17/02
CPCA61K8/97A61K8/365A61K8/4926A61K8/922A61Q17/02
Inventor 万小耀
Owner 东莞小猕猴户外用品有限公司
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