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Microfluidic Chip

A technology of microfluidic chips and microchannels, which is applied in the field of biological sciences, can solve the problems of high cost, limited application range, and high technical requirements, and achieve the effects of improving detection sensitivity, improving detection efficiency, and increasing detection concentration

Active Publication Date: 2019-07-23
POLYSTAR DIGIDISC CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The sample enrichment microfluidic chip solution disclosed in the above two patent documents has high technical requirements, high implementation cost, and limited application range

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The operating environment temperature is 25°C and the relative humidity is 66%.

[0052] The polystyrene (PS) microfluidic chip substrate with the prefabricated microfluidic channel is sputter-coated to form a layer of silicon dioxide film on the substrate for future use.

[0053] Dissolve polyimide (PI) in CHCl 3 , configured as a 2% concentration of PI solution.

[0054] Use a microsampler to apply the above PI solution on the silicon dioxide film layer of the polystyrene (PS) microfluidic chip substrate, the PI solution spreads naturally and begins to form a transparent liquid film, accompanied by CHCl 3 volatilization, the transparent liquid film gradually solidifies, when CHCl 3 After all volatilization, a silicon dioxide film / polyimide composite film layer is formed on the base layer of the polystyrene (PS) microfluidic chip, and the outermost layer is a polyimide film. See figure 2 .

[0055] The substrate and the cover plate are sealed to form a microfluid...

Embodiment 2

[0058] The operating environment temperature is 25°C and the relative humidity is 42%.

[0059] The polycarbonate (PC) microfluidic chip substrate with the prefabricated microfluidic channel is sputter-coated to form a layer of silicon film on the base layer for future use.

[0060] Dissolve polyimide (PI) in CHCl 3 , configured as a 2% concentration of PI solution.

[0061] Use a microsampler to apply the above PI solution on the silicon film layer of the polycarbonate (PC) microfluidic chip substrate, the PI solution spreads naturally and begins to form a transparent liquid film, accompanied by CHCl 3 volatilization, the transparent liquid film gradually solidifies, when CHCl 3 After all volatilization, a silicon film / polyimide composite film layer is formed on the base layer of the polycarbonate (PC) microfluidic chip, and the outermost layer is a polyimide film.

[0062] The substrate and the cover plate are sealed to form a microfluidic chip.

[0063] The outermost po...

Embodiment 3

[0065] Test condition and operation are with embodiment 1, difference is:

[0066] The polystyrene (PS) microfluidic chip substrate with the prefabricated microfluidic channel is sputter-coated to form a layer of aluminum film on the base layer for future use.

[0067] Use a microsampler to coat the PI solution on the aluminum film layer of the polystyrene (PS) microfluidic chip substrate, the PI solution spreads naturally and begins to form a transparent liquid film, accompanied by CHCl 3 volatilization, the transparent liquid film gradually solidifies, when CHCl 3 After all volatilization, an aluminum film / polyimide composite film layer is formed on the base layer of the polystyrene (PS) microfluidic chip, and the outermost layer is a polyimide film.

[0068] The substrate and the cover plate are sealed to form a microfluidic chip.

[0069] The outermost polyimide membrane passed the test, and the formed pore size was about 5 microns.

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Abstract

The invention provides a novel micro-fluidic chip. The micro-fluidic chip is sealed by a substrate and a cover plate, and has a basic layer and a micro-fluidic channel located on the basic layer, and at least two coating films are arranged on the surface of the base layer or the surface of the micro-fluidic channel. The outermost layer film of the at least two coating films is a polyimide film, and is of a porous structure. Due to the coating film structure on the surface of the base layer or the surface of the micro-fluidic channel, and particularly due to the three-dimensional porous structure of the micro-fluidic channel covered with the polyimide film with the porous structure, multiple to-be-tested samples and / or reagents can be contained, for example, in protein testing, it is achieved that the sample quantity is detected in a gathered mode, the detection concentration of the to-be-tested samples is increased, and the detection efficiency and the detection sensitivity are improved.

Description

technical field [0001] The invention relates to a microfluidic chip, which belongs to the technical field of biological sciences. Background technique [0002] Microfluidics is the integration of basic operating units such as sample preparation, reaction, separation, and detection in biological, chemical, and medical analysis processes into a micron-scale chip to automatically complete the entire analysis process. It has great potential in the fields of biology, chemistry, medicine, etc., and has developed into a new research field interdisciplinary in biology, chemistry, medicine, fluid, electronics, materials, and machinery. [0003] Microfluidic chips, such as figure 1 As shown, it is a miniature biochemical analysis system with broad application prospects, which can significantly reduce the cost of biochemical detection and improve detection efficiency. The channel size of the microfluidic chip is on the order of microns. While significantly reducing the cost of bioche...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00
CPCB01L3/5027B01L3/502707B01L2300/0887B01L2300/0893B01L2300/12
Inventor 吴大林苏辰宇陈辉吴靖轩谈晓峰
Owner POLYSTAR DIGIDISC CO LTD
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