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Preparing method of breast cancer specificity CTLs

A breast cancer-specific technology, which is applied in the field of preparation of breast cancer-specific CTLs, can solve the problems of long survival time in vivo and a large number of killing effects, and achieve the effect of promoting apoptosis

Inactive Publication Date: 2017-03-15
深圳中健生物技术有限公司
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Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a method for preparing breast cancer-specific CTLs, which solves the problem that in the process of existing immunotherapy for breast cancer, it is impossible to quickly and massively obtain immunotherapy with strong killing effect and long survival time in vivo effector cell problem

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  • Preparing method of breast cancer specificity CTLs
  • Preparing method of breast cancer specificity CTLs
  • Preparing method of breast cancer specificity CTLs

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Embodiment Construction

[0024] Embodiments of the present invention will be specifically described below in conjunction with the accompanying drawings.

[0025] Killer T cells (CTLs: Cytotoxic T-cell lymphocytes) are a kind of specific T cells that secrete various cytokines to participate in immune function. It has a killing effect on antigenic substances such as certain viruses and tumor cells, and forms an important line of defense for the body's anti-virus and anti-tumor immunity with natural killer cells. The most critical thing in the treatment process of immunotherapy using CTLs to specifically eliminate tumors is to obtain a large number of immunotherapy effector cells with strong killing effect and long survival time in vivo.

[0026] The main innovation of the present invention is: breast cancer stem cells are isolated from the breast cancer patient's autologous cancer tissue, and then the patient's autologous dendritic cells (DC cells: Dendritic Cell) are fused with the patient's autologous...

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Abstract

The invention relates to a preparing method of breast cancer specificity CTLs, and belongs to the technical field of biological pharmacy. The preparing method includes the steps that breast cancer stem cells are separated from autologous cancer tissue of a breast cancer patient, then the cell fusion technology is used for fusing autologous DC cells of the patient and the autologous breast cancer stem cells to obtain fused cells with characteristics of the breast cancer stem cells and antigen transmissibility of the DC cells, and then cytotoxic T-cells (CTLs) capable of specifically killing the breast cancer stem cells can be generated in quantity through stimulation. The obtained CTLs capable of specifically killing the breast cancer stem cells are returned into the body of the patient, and the effects of killing the breast cancer stem cells and preventing relapse and transfer can be achieved.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals, and more specifically relates to a method for preparing breast cancer-specific CTLs. Background technique [0002] Breast cancer is one of the most common cancers in women all over the world, accounting for the third of new cancers and the fifth of cancer-related deaths. The total number of malignant tumors in women is 21%. There are about 79,000 new cases of breast cancer every year, with a clear upward trend, and it has become a serious threat to women's health and life. Studying the prevention and treatment of breast cancer is an important task for scientists all over the world. [0003] At present, there are three main methods of breast cancer treatment: surgery, radiotherapy and chemotherapy. Surgical treatment is a radical cure for early breast cancer, and it is often used as a palliative treatment for advanced breast cancer, and postoperative patients are often accompanied by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/0783
CPCC12N5/0638
Inventor 张明肖洪宝
Owner 深圳中健生物技术有限公司
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