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Composition for preventing, treating or inhibiting mucous membrane disease and preparation method thereof

A composition and disease technology, applied in skin diseases, drug combinations, pharmaceutical formulas, etc., can solve problems such as oral ulcers

Inactive Publication Date: 2017-03-01
康多宝医疗健康产品(湖南)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is still no generally accepted measure to completely prevent oral ulcers

Method used

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  • Composition for preventing, treating or inhibiting mucous membrane disease and preparation method thereof
  • Composition for preventing, treating or inhibiting mucous membrane disease and preparation method thereof
  • Composition for preventing, treating or inhibiting mucous membrane disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A composition for preventing, treating or inhibiting mucosal diseases and a preparation method thereof, characterized in that the component content of the composition is:

[0035]

[0036] System stability: The system is a single stable viscous liquid, and the quality indicators of the test product have no obvious changes after being placed for 3 months under the conditions of temperature 37°C±2°C and relative humidity 75%±5%.

[0037] Microbial killing effect: According to the detection method of "Disinfection Technical Specifications", the logarithmic values ​​of killing Staphylococcus aureus and Escherichia coli were both > 6.00 when the original solution was applied for 1 minute; the logarithmic values ​​of killing Candida albicans were both > 6.00 after the original solution was applied for 1 minute . Experiments have shown that it has a good killing effect on oral pathogens.

[0038] Biological Evaluation:

[0039] The cytotoxicity test of the composition of ...

Embodiment 2

[0044] A composition for preventing, treating or inhibiting mucosal diseases and a preparation method thereof, characterized in that the component content of the composition is:

[0045]

[0046] System stability: The system is a single stable viscous liquid, and the quality indicators of the test product have no obvious changes after being placed for 3 months under the conditions of temperature 37°C±2°C and relative humidity 75%±5%.

[0047] Microbial killing effect: According to the detection method of "Disinfection Technical Specifications", the logarithmic values ​​of Staphylococcus aureus and Escherichia coli were both greater than 3.00 when the stock solution was applied for 3 minutes; . Experiments have shown that it has a good killing effect on oral pathogens.

[0048] Biological Evaluation:

[0049] The cytotoxicity test of the composition of Example 2 was carried out by the MTT method, and the cytotoxicity level was judged by the relative cell proliferation rate...

Embodiment 3

[0054] A composition for preventing, treating or inhibiting mucosal diseases and a preparation method thereof, characterized in that the component content of the composition is:

[0055]

[0056] System stability: The system is a single stable viscous liquid, and the quality indicators of the test product have no obvious changes after being placed for 3 months under the conditions of temperature 37°C±2°C and relative humidity 75%±5%.

[0057] Microbial killing effect: According to the detection method of "Disinfection Technical Specifications", the logarithmic values ​​of Staphylococcus aureus and Escherichia coli were both greater than 3.00 when the original solution was applied for 1 minute; the logarithmic values ​​of Candida albicans were both greater than 3.00 when the original solution was applied for 1 minute . Experiments have shown that it has a good killing effect on oral pathogens.

[0058] Biological Evaluation:

[0059] The cytotoxicity test of the compositio...

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PUM

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Abstract

The invention relates to a composition for preventing, treating or inhibiting mucous membrane disease and a preparation method thereof. The composition can be a liquid preparation or a semisolid preparation form, and comprises the following components in parts by weight: 0.001-35.0% of an antimicrobial agent, 0-10.0% of an analgesic, 0.001-20.0% of a biological adhesive, 0-30.0% of a humectants, 0-5.0% of a pH conditioning agent, 0-8.0% of a flavouring, 0-5.0% of an emulsifier, and 0-8.0% of an auxiliary antimicrobial agent. The composition is applied on the surfaces of skin and a mucous membrane, has effects for preventing and treating mucous membrane disease or illness , is affected on an administration position to release an antimicrobial agent to effectively kill the harmful microbes, simultaneously has bio-adhesive performances, can stay at the administration position for long term, isolates microbe infection, prevents secondary infection, and accelerates wound healing.

Description

technical field [0001] The invention relates to a composition for preventing, treating or inhibiting mucosal diseases or symptoms and a preparation method thereof. The composition may be in the form of a liquid preparation or a semi-solid preparation, and the composition is applied to the skin, mucosal surface, such as the oral cavity , nasal cavity, gastrointestinal tract and respiratory tract, vagina, bladder, genitals, epidermis, etc., to prevent and treat mucosal diseases or conditions, including ulcers, inflammation, traumatic injury or corrosive injury, infection of microorganisms, etc., such as oral ulcers (oral sores) ), cold sores, radiation-induced skin ulcers, genital tract ulcers, gastric mucosal ulcers, intestinal mucosal ulcers, actinic keratosis, Behcet's syndrome, warts, bad breath, swollen gums, etc.; Stay at the administration site, releasing antimicrobial agents that can effectively kill harmful microorganisms. At the same time, this composition is bioadhesi...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61P1/02A61P17/02A61P1/04
Inventor 肖本友吴静红张献冲李姿肖荞刘耀
Owner 康多宝医疗健康产品(湖南)有限公司
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