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Antibacterial microcapsule with clove oil embedded in laurinol modified alginic acid derivative and preparation method of antibacterial microcapsule

A technology for modifying algae and acid derivatives, applied in microcapsule preparations, microsphere preparation, flexible coverings, etc., can solve the problems of hindering the application of antibacterial packaging materials, volatile clove oil, low water solubility, etc., and achieve enhanced The effect of food shelf life, improving hydrophilicity and improving food quality

Inactive Publication Date: 2017-02-22
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main component of clove oil is eugenol, which is a natural antibacterial agent with good antibacterial properties. However, clove oil is volatile in the external environment, sensitive to light and temperature, and has extremely low water solubility, which hinders its antibacterial effect. Application in packaging materials
[0004] At present, there are few reports on the modification of sodium alginate in the industry

Method used

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  • Antibacterial microcapsule with clove oil embedded in laurinol modified alginic acid derivative and preparation method of antibacterial microcapsule
  • Antibacterial microcapsule with clove oil embedded in laurinol modified alginic acid derivative and preparation method of antibacterial microcapsule
  • Antibacterial microcapsule with clove oil embedded in laurinol modified alginic acid derivative and preparation method of antibacterial microcapsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Preparation of lauryl alcohol modified alginic acid derivative SA-Da:

[0027] a. Prepare a mixed solution according to the volume ratio of formamide:N,N-dimethylformamide 10:9; weigh 1g sodium alginate, put it into 40mL mixed solution, and quickly add 0.5g p-toluenesulfonic acid, stir and acidify 35min; then add 0.4g EDC-HCl and 0.5g 4-dimethylaminopyridine DMAP and stir evenly, and finally add 5g lauryl alcohol, stir and react in a water bath at 55°C for 24h;

[0028] b. Pour the reaction solution obtained in step a into 175 mL of absolute ethanol solution, and rapidly centrifuge for 15 minutes to obtain a precipitate at a centrifugal speed of 5000 rpm; vacuum-dry the precipitate at 0-0.1 MPa, 30-40°C for 20 h, get dry matter;

[0029] c. Dissolve the dried product obtained in step b in 40mL deionized water, stir until completely dissolved, and add NaHCO with a mass concentration of 2%. 3 Adjust the pH of the aqueous solution to neutral; vacuum-dry the obtained ...

Embodiment 2

[0034] (1) Preparation of lauryl alcohol modified alginic acid derivative SA-Da:

[0035] a. Prepare a mixed solution according to the volume ratio of formamide:N,N-dimethylformamide 9:9; weigh 1g sodium alginate, put it into 30mL mixed solution, and quickly add 0.4g p-toluenesulfonic acid, stir and acidify 25min; then add 0.3g EDC-HCl and 0.4g 4-dimethylaminopyridine DMAP and stir evenly, finally add 4g lauryl alcohol, stir and react in a water bath at 50°C for 30h;

[0036] b. Pour the reaction solution obtained in step a into 170 mL of absolute ethanol solution, and rapidly centrifuge for 30 minutes to obtain a precipitate at a centrifugal speed of 4000 rpm; vacuum-dry the precipitate at 0-0.1 MPa, 30-40°C for 30 h, get dry matter;

[0037] c. Dissolve the dried product obtained in step b in 30mL deionized water, stir until completely dissolved, and add NaHCO with a mass concentration of 2%. 3 The pH of the aqueous solution is adjusted to neutral; the obtained neutral sol...

Embodiment 3

[0041] (1) Preparation of lauryl alcohol modified alginic acid derivative SA-Da:

[0042] a. Prepare the mixed solution according to the volume ratio of formamide:N,N-dimethylformamide 10:9; weigh 1g sodium alginate, put it into 40mL mixed solution, and quickly add 0.6g p-toluenesulfonic acid, stir and acidify 45min; then add 0.5g EDC-HCl and 0.6g 4-dimethylaminopyridine DMAP and stir evenly, finally add 6g lauryl alcohol, stir and react in a water bath at 60°C for 20h;

[0043] b. Pour the reaction solution obtained in step a into 170 mL of absolute ethanol solution, and rapidly centrifuge for 20 minutes to obtain a precipitate at a centrifugal speed of 4500 rpm; vacuum-dry the precipitate at 0-0.1 MPa, 30-40°C for 25 hours, get dry matter;

[0044] c. Dissolve the dried product obtained in step b in 50mL deionized water, stir until it is completely dissolved, and add NaHCO with a mass concentration of 2%. 3 Adjust the pH of the aqueous solution to neutral; vacuum-dry the o...

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Abstract

The invention relates to an antibacterial microcapsule with clove oil embedded in a laurinol modified alginic acid derivative and a preparation method of the antibacterial microcapsule, and belongs to the technical field of modification of high polymer materials. The antibacterial microcapsule comprises sodium alginate, laurinol and clove oil.The preparation method comprises the following steps that firstly laurinol is used to modify sodium alginate to obtain sodium alginate graft-copolymerized laurinol SA-Da, and then the clove oil is embedded to obtain the antibacterial microcapsule with the clove oil embedded in the laurinol modified alginic acid derivative. The prepared slow-release antibacterial microcapsule is relatively high in antibacterial property, can effectively inhibit the growth and propagation of microorganisms, has a certain slow release effect, slowly releases the antibacterial ingredient of the clove oil along with the change of time, has an excellent slow-release antibacterial effect, and can be applied to a food packaging film to prolong the food shelf-life and improve the food quality, and therefore, the antibacterial microcapsule has an excellent market prospect.

Description

technical field [0001] The invention relates to an antibacterial microcapsule in which clove oil is embedded in a lauryl alcohol-modified alginic acid derivative and a preparation method thereof, belonging to the technical field of polymer material modification. Background technique [0002] Sodium alginate is a kind of polyelectrolyte, which interacts with divalent cations to make the molecular chains of sodium alginate tightly bonded. By mixing sodium alginate with antibacterial substances, the mixture is slowly added dropwise at a certain rate to the solution containing divalent calcium In ionic aqueous solution, the formation of gel microspheres containing antibacterial substances has been extensively studied, but it has been found from the research that sodium alginate molecules contain a large amount of -COONa and -OH, which is a highly hydrophilic polysaccharide polymer , the embedding rate of hydrophobic antibacterial agents is low, and there is a burst release pheno...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L91/00C08L5/04C08L101/00C08B37/04B01J13/02B65D65/38
CPCC08L101/00B01J13/02B65D65/38C08B37/0084C08L2203/16C08L2205/03
Inventor 王利强陆敏马淑凤林炎宋会民张贺张晨凤薛家蓉赵婉怡
Owner JIANGNAN UNIV
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