Application of oroxylin A in preparation of inhibitor with targeting effect on AFP (alpha fetoprotein) of hepatoma cells
A technology of liver cancer cells and alpha-fetoprotein, which is applied in the field of tumor drugs, can solve the problems such as the research report on liver cancer cells without Melaleuca, and achieve the effect of good clinical value.
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[0018] In this study, an in-depth study was carried out on the anti-hepatic cancer target and mechanism of the flavonoid tumor compound celesteol. Through cell biology, biochemistry and other research methods, it was found that melaleucain can target AFP, the clinical diagnostic marker of liver cancer, down-regulate its gene and protein levels, and directly bind to AFP, inhibiting the combination of AFP and tumor suppressor protein PTEN, and then Inhibit the proliferation of liver cancer cells and induce apoptosis of liver cancer cells.
[0019] 1. Experimental materials
[0020] (1) Drugs
[0021] Melaleuca paper (C 16 h 12 o 5 , with a relative molecular weight of 284.263) was purchased from the School of Pharmacy, China Pharmaceutical University (Patent No. ZL2009 1 0029867.9), with a purity of over 99%. It was prepared as a 200mM mother solution in DMSO and stored at -20°C. Dilute to the desired concentration with serum-containing culture medium before use.
[0022] ...
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