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Method for extracting cannabidiol from industrial hemp floral leaves

A technology of industrial hemp and cannabidiol, which is applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve problems such as low purity of cannabidiol and residual tetrahydrocannabinol, and achieve product safety guarantee , Improve the purity and reduce the effect of pollution

Inactive Publication Date: 2017-01-04
YUNNAN HANSU BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The present invention aims to provide a method for extracting cannabidiol from industrial hemp flowers and leaves, so as to solve the problems in the prior art that the purity of cannabidiol is not high and the psychotoxic component tetrahydrocannabinol remains

Method used

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  • Method for extracting cannabidiol from industrial hemp floral leaves
  • Method for extracting cannabidiol from industrial hemp floral leaves
  • Method for extracting cannabidiol from industrial hemp floral leaves

Examples

Experimental program
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Embodiment approach

[0054] According to a typical embodiment of the present invention, macroporous resins include AB-8, D-101, XDA-8, LSA-7, D-941, DM-130, ADS-17, SP-825 and HPD-600 one or more of . The above-mentioned type of resin is cheap and easy to regenerate, and is used for the preliminary purification of cannabidiol.

[0055] According to a typical embodiment of the present invention, step 7) further includes a step of recovering ethanol in the eluent.

[0056] Preferably, step 7) includes supersaturated dissolution with 60-100% ethanol at a temperature of 10-80°C to obtain crystals. Preferably, step 8) specifically includes: washing with purified water or 5-40% ethanol at a temperature of 0-24°C to obtain the primary product.

[0057] Preferably, in step 9), the drying method includes one or more of spray drying, vacuum drying, near-infrared drying, and microwave drying, and the drying temperature does not exceed 65°C.

[0058] Preferably, after step 9), a step of pulverizing the obt...

Embodiment 1

[0061] The method of the present invention prepares cannabidiol

[0062] This experiment provides the use of the method described in the present invention to prepare cannabidiol under different technical parameters. The amount of industrial hemp flowers and leaves taken in this experiment is 10 kg.

[0063] method 1:

[0064] 1) Pulverize the flowers and leaves of the industrial hemp used in the experiment, and pass through an 80-mesh sieve to obtain medicinal material powder. Under the temperature condition of 60°C, it was dried for 3 hours, and the moisture content was 4% through detection.

[0065] 2) The above medicinal material powder was extracted with 2 times the amount of 30v% ethanol and refluxed for 3 times, each time for 0.5h, to obtain an extract;

[0066] 3) Concentrate the above extract, and when concentrated to 50°C, the relative density is 1.05 to obtain the extract;

[0067] 4) Use 1 times the purified water for the above-mentioned extract, and sink in wate...

Embodiment 2

[0107] Example 2 Preparation of cannabidiol by different extraction methods

[0108] This experiment medicinal material amount is identical with embodiment 1

[0109] Ultrasonic extraction:

[0110] 1) Pulverize the flowers and leaves of the industrial hemp used in the experiment, and pass through a 40-mesh sieve to obtain medicinal material powder. Under the temperature condition of 120°C, it was dried for 1 hour, and the moisture content was 2.6% through testing.

[0111] 2) Using 5 times the amount of the above medicinal material powder, 80v% ethanol, and 70 Hz, ultrasonically extracting twice, each time for 0.5h, to obtain an extract;

[0112] 3) Concentrate the above extract, and when concentrated to 50°C, the relative density is 1.1 to obtain the extract;

[0113] 4) Use 5 times of purified water for the above-mentioned extract, and sink in water for 12 hours at a temperature of 4°C to obtain a water-sinking liquid;

[0114] 5) Centrifuge the above-mentioned water se...

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Abstract

The invention discloses a method for extracting cannabidiol from industrial hemp floral leaves. The method comprises the following steps: grinding and drying floral leaves of industrial hemp, thereby obtaining medicinal powder; extracting the medicinal powder by adopting 30-100v% of ethanol, thereby obtaining extracting solution; concentrating the extracting solution to obtain extract; performing water precipitation on the extract, removing the impurities, thereby obtaining water precipitation solution; centrifuging the water precipitation solution, adding 10-100v% of ethanol into the obtained precipitate, dissolving to obtain an alcoholic solution of the precipitate; performing column chromatography on the alcoholic solution of the precipitate; concentrating the eluent obtained by eluting after column chromatography, adding ethanol to perform supersaturation dissolving, thereby obtaining a crystal; adding the crystal into purified water or ethanol for washing, thereby obtaining a primary product; uniformly mixing the primary product by using the purified water, drying, thereby obtaining the cannabidiol. According to the method disclosed by the invention, the highly safe ethanol serves as a solvent, so that the purity of the cannabidiol in the finished product is improved, a psychotoxic component, namely tetrahydrocannabinol, is removed, the product safety is improved, and the method is suitable for industrial production.

Description

technical field [0001] The invention relates to a method for extracting cannabidiol from industrial hemp, in particular to a method for extracting cannabidiol from industrial hemp flowers and leaves. Background technique [0002] Cannabis (scientific name: Cannabis sativa L.) is a plant of the Cannabis family and the genus Cannabis, also known as hemp, hemp, hemp, mountain silk seedlings, and jute. It has important agricultural and medicinal values. Marijuana contains a toxic component THC (tetrahydrocannabinol), which can make people hallucinogenic and addictive, and can be used as a drug. It was banned for a long time. [0003] Due to the high economic and medicinal value of hemp, the raw material hemp exclusively for industrial use is referred to as "industrial hemp". The value of the toxic component tetrahydrocannabinol or directly as a drug can be legally carried out in large-scale cultivation and industrial development and utilization. [0004] At present, more than ...

Claims

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Application Information

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IPC IPC(8): C07C37/68C07C37/82C07C37/84C07C39/23
CPCC07C37/685C07C37/82C07C37/84C07C39/23C07C37/68C07C2601/16C07C39/42
Inventor 张可谭昕高伟博常坦然
Owner YUNNAN HANSU BIO TECH CO LTD
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