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Yizhi Artemisia Compound Oral Preparation and Application

An oral preparation and compound technology, applied in the field of Artemisia annua compound oral preparation, can solve problems such as failure to show long-term efficacy and the like

Active Publication Date: 2019-11-15
新疆维吾尔自治区维吾尔医药研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Endoscopic therapy is a newly developed treatment technology, mainly including anti-reflux therapy, cardia suture, submucosal injection of drugs, radiofrequency energy, thermal injury, etc. Long-term efficacy

Method used

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  • Yizhi Artemisia Compound Oral Preparation and Application
  • Yizhi Artemisia Compound Oral Preparation and Application
  • Yizhi Artemisia Compound Oral Preparation and Application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1 (preparation of tablet based on 1 part)

[0015] Weigh 300g of Artemisia argyi, 200g of Smilax, 200g of gall, 100g of sea octopus, 100g of coriander seed, 100g of coral, and 100g of black cumin, mix them, crush them through a 100-mesh sieve, and sterilize them according to conventional pharmaceutical methods to make therapeutic Tablet oral preparations for reflux esophagitis and gastritis, 3 times a day, 7 grams each time.

Embodiment 2

[0016] Embodiment 2 (capsules are prepared on the basis of 1 part)

[0017] 30g Artemisia argyi, 50g Smilax, 40g gall, 20g sea octopus, 50g coriander, 30g coral, 50g Nigella, mixed, stirred evenly, crushed through a 100-mesh sieve, sterilized according to conventional pharmaceutical methods, and prepared The capsule oral preparation for treating reflux esophagitis and gastritis is 3 times a day, 7 grams each time.

Embodiment 3

[0018] Embodiment 3 (preparation of granules based on 1 part)

[0019] Artemisia argyi 150g, Smilax 100g, Gallus 100g, Sea octopus 50g, Coriander 50g, Coral 50g, Nigella 50g, mixed, stirred evenly, crushed through a 200-mesh sieve, sterilized according to conventional pharmaceutical methods, and prepared The granule preparation for treating reflux esophagitis and gastritis is 3 times a day, 7 grams each time.

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Abstract

The invention relates to an alpine-yarrow-herb compound oral preparation and an application. The oral preparation is prepared from alpine yarrow herbs, smilax china, gallnuts, cuttlebones, coriander seeds, corals and fennelflower seeds. The alpine-yarrow-herb compound oral preparation has the obvious promoting effect on the rat in-vitro gastrointestinal smooth muscle contractile activity, has the obvious protective effect on the rat reflux esophagitis mucosa, has the obvious inhibiting effect on acute inflammation caused by mouse ear swelling induced by dimethylbenzene, subacute inflammation caused by rat toe swelling induced by carrageenan, chronic inflammation caused by rat cotton pellet granuloma and generation of inflammation mediator PGE2, and has the neutralization effect on acid indigestion. Clinical researching and experimental researching show that the alpine-yarrow-herb compound oral preparation is capable of removing local abnormal biliary fluid and blood stasis, astringing and inducing astringency, promoting digestion and descending qi, and has the remarkable treating effect on reflux esophagitis and gastritis.

Description

technical field [0001] The invention relates to a compound oral preparation of Yizhi Artemisia and its application. The preparation is used in medicine for reflux esophagitis and gastritis. Background technique [0002] Gastroesophageal reflux disease (GERD) is a disease caused by multiple factors. At present, most scholars believe that its pathogenesis is mainly the weakening of the anti-reflux defense mechanism and the enhancement of the attack effect of reflux on the esophagus. The former include: decreased lower esophageal sphincter (LES) pressure, transient lower esophageal sphincter relaxation, decreased esophageal clearance, weakened anti-reflux effect of septum, concurrent hiatal hernia, impaired esophageal mucosal barrier, and gastroduodenal function abnormal. The latter mainly refers to the attack of gastric acid, pepsin and duodenal reflux. In addition, studies have shown that age, sex, obesity, smoking, drinking, mental and psychological factors and genetic fa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/90A61K36/896A61P1/04A61K35/618A61K35/64A61K35/614
CPCA61K35/614A61K35/618A61K35/63A61K36/23A61K36/28A61K36/71A61K36/896A61K36/90A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 斯拉甫·艾白李治建
Owner 新疆维吾尔自治区维吾尔医药研究所
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