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Callicarpa nudiflora extract with anti-inflammatory effect

A technology of violacea quinquefolium and anti-inflammatory effect, applied in the field of medicine, can solve the problems of difference in efficacy, lack of obviousness, little research on anti-inflammatory activity, etc., and achieve the effects of strong anti-inflammatory activity and simple and convenient preparation method.

Inactive Publication Date: 2017-01-04
JIUZHITANG
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the effects of different parts and different chemical components of Nadiflora are significantly different. At present, there are relatively few studies on the anti-inflammatory activity of Nadiflora components, such as "Experimental Research on the Anti-inflammatory Effect of Nadiflora and Immunity Enhancement" (Guangdong Trace Element Science, 2006, 13(8): 39-41), Anti-inflammatory and Hemostatic Effects of Total Flavonoids of Auranthus chinensis (Journal of Modern Traditional Chinese and Western Medicine, 2009, 18(6): 3161-3162), Aurora chinensis Purple Pearl 5_hydroxyl_3_7_3_4_tetramethoxyflavone anti-inflammatory effect research (Journal of Hainan Medical College, 2014, 20 (11): 1460-1462), this kind of research or is based on the crude extract of naked flower purple pearl, Or take the single compound isolated from P. nudiflora as the research object. These existing technologies are not yet simple for the research on the pharmacodynamic material basis of the anti-oxidation effect of P. nudiflora, and the effective parts with high anti-inflammatory activity are obtained and developed. It is of great significance to become the end product

Method used

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  • Callicarpa nudiflora extract with anti-inflammatory effect
  • Callicarpa nudiflora extract with anti-inflammatory effect
  • Callicarpa nudiflora extract with anti-inflammatory effect

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Embodiment Construction

[0035] The present invention will be further illustrated in detail below by way of examples. The inventors obtained corresponding examples and comparative examples through different preparation processes, and measured the components, contents, yields, inhibition rates, etc., as shown in Table 3 below.

[0036] The inventor makes embodiment by following process:

[0037] (1) Take the medicinal material of Aurora nudiflora, crush it into a coarse powder, add 90-95% ethanol and heat it under reflux for extraction 1-3 times to obtain an extract, and after filtering, the obtained filtrate is concentrated into an extract A;

[0038] (2) The extract A obtained in the step (1) is evenly dispersed in water, sequentially added petroleum ether and ethyl acetate for extraction, and the solvent is removed to obtain petroleum ether extraction effective fraction B and ethyl acetate extraction fraction C respectively;

[0039] (3) Mix the effective part B and the effective part C at a weight ...

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Abstract

The invention discloses a callicarpa nudiflora extract with an anti-inflammatory effect. The callicarpa nudiflora extract contains 24%-36% of flavonoid compound, 0.8%-3% of phenethyl alcohol glycoside and 15%-27% of diterpenoid compound. The obtained callicarpa nudiflora extract has high anti-inflammatory activity.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an extract of Auranthus nudiflora with anti-inflammatory activity. Background technique [0002] Callicarpa nudiflora Hook.et Arn. is a plant of the genus Callicarpa nudiflora Hook.et Arn. It is produced in Hainan, Guangxi, Guangdong, India, Vietnam, Malaysia and other places. Its roots and leaves can be used as medicine and have astringent properties. Hemostasis, anti-inflammatory and detoxification effects. The pharmacologically active parts of Auranthus nudiflora reported in the existing literature are mostly alcohol extracts and water extracts, and their activities mainly include five aspects: hemostasis, anti-inflammation, immune enhancement, cytotoxic activity and antibacterial. However, the effects of different parts and different chemical components of Nadiflora are significantly different. At present, there are relatively few studies on the anti-inflammatory activity of Nadiflor...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61P29/00
Inventor 潘争红谷陟欣黄思思黄胜颜冬兰宁德生李典鹏
Owner JIUZHITANG
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