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Constructing method for preparing nano target controlled release system from hyaluronic acid and chitosan modified graphene oxide

A technology of chitosan modification and hyaluronic acid, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve problems such as sedimentation, achieve high drug loading rate, mild and simple construction method, excellent slow and controlled release and target effect on function

Inactive Publication Date: 2016-12-21
GUANGZHOU CHUANGSAI BIOLOGICAL MEDICAL MATERIALS CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, although graphene oxide contains carboxyl, hydroxyl and other groups and can be dispersed in water, it will settle in salt solution due to electrostatic shielding.

Method used

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  • Constructing method for preparing nano target controlled release system from hyaluronic acid and chitosan modified graphene oxide
  • Constructing method for preparing nano target controlled release system from hyaluronic acid and chitosan modified graphene oxide
  • Constructing method for preparing nano target controlled release system from hyaluronic acid and chitosan modified graphene oxide

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Embodiment 1

[0027] Example 1 A method for constructing a nano-targeted slow-controlled release system prepared by modifying graphene oxide with hyaluronic acid and chitosan

[0028] The hyaluronic acid of this embodiment, chitosan modified graphene oxide prepares the construction method of nano target sustained and controlled release system, comprises the following steps:

[0029] (1), dispersing 10mg graphene oxide in 10ml ultrapure water to obtain a graphene oxide solution with a concentration of 1mg / ml, dissolving 20mg chitosan in 20ml acetic acid buffer solution to obtain a concentration of chitosan with a concentration of 1mg / ml solution, after mixing the two solutions, ultrasonically treat them at 100kHZ for 30min, then carry out magnetic stirring at 32°C for 24 hours, dialyze the mixed solution after stirring for 3 days, change the ultrapure water once in 24 hours, and dry in vacuum to obtain chitosan modified Sexual graphene oxide;

[0030] (2), disperse the chitosan-modified gra...

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Abstract

The invention discloses a constructing method for preparing a nano target controlled release system from hyaluronic acid and chitosan modified graphene oxide. The method comprises the steps that a graphene oxide solution and a chitosan solution are mixed, then the mixed solution is mixed with a hyaluronic acid solution, then an Hsp90 inhibitor is added, vacuum drying is carried out, and the nano target controlled release system is obtained. The transmission electron microscope, drug loading ratio, release rate, cytotoxicity and other performance of the formed nano target controlled release system are tested, and the result indicates that the system has good controlled release and target functions.

Description

technical field [0001] The invention belongs to the technical field of nano-drug carriers, and in particular relates to a method for preparing a nano-targeted slow-controlled release system by modifying graphene oxide with hyaluronic acid and chitosan. Background technique [0002] Studies have found that graphene oxide (GO), as a new type of three-dimensional nano-nanomaterial, has many unique and superior properties, including high specific surface area, cell membrane penetration, drug loading, good biocompatibility, and easy processing. Surface modification, non-immunogenic properties, etc., and these properties are particularly suitable as the core part of the targeted sustained and controlled release system of nano-drugs. One of the ways for foreign substances to enter the cell membrane is endocytosis, which requires energy and also needs to occur through changes in the curvature of the cell membrane. Studies have shown that the high surface energy of graphene oxide ca...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/36A61K47/04A61K31/416B82Y5/00A61P35/00A61K31/395A61K31/7048
CPCA61K9/0002A61K31/395A61K31/416A61K31/7048B82Y5/00
Inventor 郭瑞蓝咏秦作斌
Owner GUANGZHOU CHUANGSAI BIOLOGICAL MEDICAL MATERIALS CO LTD
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