Compound Microsystem for Multi-channel Fluorescence Microscopy
A microscopic system and multi-channel technology, applied in the field of microscopy, can solve the problems of difficult operation and increased cost, and achieve the effect of reducing scientific research costs and improving instrument utilization.
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Embodiment 1
[0029] figure 1 The present invention includes a microscope main body, a SCMOS or EMCCD camera, and a composite lighting module, which includes a light source and a bright field light lighting submodule, a two-color fluorescent positioning lighting submodule, a structured light lighting submodule, and a fluorescence recovery function after photobleaching Lighting sub-module. The light source enters into the microscope main body through each illumination sub-module, and irradiates on the sample. The sample selection is mapped on the bright field imaging sub-module, the two-color fluorescence localization imaging sub-module, the structured light illumination imaging sub-module and the fluorescence recovery imaging sub-module after photobleaching. figure 2 The two-color fluorescent positioning lighting submodule and the bright field light lighting submodule are in the first lighting system 1, the structured light lighting submodule and the fluorescent recovery function lighting...
Embodiment 2
[0034] The imaging modes of the composite microscope system are: bright field imaging (high temporal resolution, large field of view); two-color fluorescence localization imaging (high spatial resolution xy direction 20nm, y direction 50nm); structured light illumination imaging (high spatial resolution xy 100nm in direction, 500nm in y direction; high temporal resolution of about 360ms per frame, imaging range of 2048*2048 pixels; high signal-to-noise ratio); fluorescence recovery imaging after photobleaching; simultaneous imaging of bright field and two-color fluorescence positioning; bright field and structured light Simultaneous imaging under illumination; Simultaneous imaging of bright field and fluorescence recovery after photobleaching. These six imaging modes can be conveniently selected by software.
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