Antisense oligonucleotide for miR-103-3p and application

Abstract

The invention belongs to the field of drug preparation, and particularly relates to antisense oligonucleotide for miR-103-3p. The nucleotide sequence of the antisense oligonucleotide for the miR-103-3p is shown as SEQ ID NO.1. The antisense oligonucleotide for the miR-103-3p can be used for preparing a drug for treating subarachnoid hemorrhage, is low in toxicity and can relieve early brain injuries occurring after subarachnoid hemorrhage.

Description

technical field [0001] The invention belongs to the field of small molecular biomedicine and relates to an antisense oligonucleotide targeting miR-103-3p and its application. Background technique [0002] Subarachnoid hemorrhage (SAH) refers to a stroke in which blood flows into the subarachnoid space after the rupture of blood vessels at the base of the brain or on the surface of the brain, causing corresponding clinical symptoms. It is also called primary subarachnoid hemorrhage. SAH accounts for about 5%-10% of all strokes, with an annual incidence of about 6-20 / 100,000 people. [0003] Common causes of SAH include congenital aneurysm, cerebrovascular malformation, abnormal vascular network disease in the base of the brain (moyamoya disease), dissecting aneurysm, vasculitis, arteriosclerosis in hypertension, etc. Blood enters the subarachnoid space, rapidly disseminates through the cerebrospinal fluid that surrounds the brain and spinal cord, and irritates the meninges c...

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Problems solved by technology

However, there is no report that inhibiting the expression of miR-103-3p has a curative effect on cerebrovascular diseases

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