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Compatible composition capable of reducing toxins and keeping effect of gelsmium elegans and compatibility method of compatible composition

A composition and technology of glyph, which is applied in the field of research on the compatibility of glyph attenuation and preservation, can solve the problems of research on toxic components and mechanism of toxicity, and achieve the effect of ensuring analgesic function and reducing toxicity

Active Publication Date: 2016-10-26
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the researches on Glycyrrhizae mainly focus on biology, chemistry, pharmacology and toxicology, but there are few reports on the attenuation and preservation effect of Gelkinonia, and there is no compatibility with its toxic components and mechanism. Research

Method used

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  • Compatible composition capable of reducing toxins and keeping effect of gelsmium elegans and compatibility method of compatible composition
  • Compatible composition capable of reducing toxins and keeping effect of gelsmium elegans and compatibility method of compatible composition
  • Compatible composition capable of reducing toxins and keeping effect of gelsmium elegans and compatibility method of compatible composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Take 10.0g of the crude drug powder of Gelkins, put it in a 150mL round bottom flask, add 50ml of water to soak for 0.5h, then reflux for 1h, extract twice, combine the supernatant, recover and concentrate under reduced pressure, then dissolve and transfer with distilled water and set When the volume reaches 10mL, 1g·ml of Gelkins extract can be obtained -1 (Based on the crude drug dose of Gelkins).

Embodiment 2

[0038] Take 10.0g of Gelkins crude drug powder, put it in a 150mL round bottom flask, add 50ml of 30% ethanol to soak for 0.5h, reflux for 1h, extract twice, combine the supernatant, recover and concentrate under reduced pressure, and then dissolve in distilled water Transfer and dilute to 10mL to obtain 1g·ml of Gelkins extract -1 (Based on the crude drug dose of Gelkins).

Embodiment 3 and Embodiment 4

[0040] The operation and consumption of embodiment 3 and embodiment 4 are the same as embodiment 2, wherein the extraction solvent is changed, in embodiment 3, the extraction solvent is 60% ethanol; in embodiment 4, the extraction solvent is 90% ethanol.

[0041] Carry out the toxicity test of the Glycyrrhizae extract according to the Gypsy extract prepared in Examples 1-Example 4, and the specific operations are as follows:

[0042] 50 KM mice were randomly divided into 5 groups (blank control group, water extract group, 30% alcohol extract group, 60% alcohol extract group and 90% alcohol extract group), 10 in each group, picric acid Marking, fasting without food and water for 12 hours before the test, and then one-time gavage at 0.6 g·kg -1 (Based on the crude drug dose of Gypsy chinensis) were given the corresponding drugs, and the blank control group was given the same volume of normal saline. Immediately after administration, the signs of poisoning and death of the mice ...

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Abstract

The invention discloses a compatible composition capable of reducing toxins and keeping effect of gelsmium elegans and a compatibility method of the compatible composition. The compatible composition is compatibility of the gelsmium elegans and a toxin lowering and effect keeping component at the weight part ratio of 1 to (5-50); the toxin lowering and effect keeping component is one of mussaenda parviflora, sheep blood and a mixture of cordate houttuynia and mint. According to the compatible composition, the compatibility of the gelsmium elegans and the mussaenda parviflora and the compatibility of the gelsmium elegans, the cordate houttuynia and the mint can realize a gelsmium elegans toxin reducing function to a certain extent; particularly, the effect of the compatibility of the gelsmium elegans and the mussaenda parviflora is relatively good. Meanwhile, the component for reducing toxins and keeping effect of the gelsmium elegans can also has pain easing effect on mice. Therefore, the compatible composition of the gelsmium elegans has obvious effects of reducing toxins and keeping effect.

Description

technical field [0001] The present invention relates to the research on the compatibility of the attenuated and preserved effect of the gecko, in particular to a compatibility composition and the compatibility method of the attenuated and preserved effect of the gecko. Background technique [0002] Gelsemium elegans, also known as heartbroken grass, mountain arsenic, kudzu, etc., is the whole plant of Gelsemiumelegans Benth., which is a plant of the genus Gelsemiumelegans Benth. It is bitter, pungent, warm in nature, and highly toxic. The effect of reducing swelling and relieving pain, mainly treating eczema, carbuncle, tinea corporis, bruises, rheumatic arthralgia, neuralgia, etc. Modern pharmacological experiments also show that it plays an important role in the treatment of tumors, pain, inflammation, immunity, and skin diseases. [0003] Due to the high toxicity of gillfish, the toxic components are mainly indole alkaloids, the therapeutic dose is very close to the pois...

Claims

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Application Information

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IPC IPC(8): A61K36/78A61K36/74A61K36/534A61K35/14A61P29/00A61P39/02A61K36/56
CPCA61K35/14A61K36/534A61K36/56A61K36/74A61K36/78A61K2236/331A61K2236/333A61K2236/35A61K2300/00
Inventor 王英豪吴水生
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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