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A method of preparing senecio dianthus franch total flavonoids and applications of the total flavonoids

A technology of senecio and total flavonoids, which is applied in the field of preparation of total flavonoids of senecio shuanghua, to achieve the effect of strong anti-lipid peroxidation ability

Inactive Publication Date: 2016-10-26
NANJING ZELANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And through the literature search, the total flavonoids of Senecio Shuanghua has not been used in the preparation of antioxidant drugs in China.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Dry the total flavonoids of Shuanghua Senecio at 60°C to obtain coarse powder; put 1000g of Shuanghua Senecio powder in a microwave-ultrasonic device, add 4L of 80% ethanol solution, set the ultrasonic 500W to normal, and the microwave power to be 800W, extracted for 3 hours, filtered, and the filtrate was concentrated under reduced pressure to obtain a concentrated solution; the concentrated solution was added to a HPD300 macroporous adsorption resin column, first eluted with 2 times the column volume of distilled water, and then washed with 6 times the column volume of 75% ethanol Remove and collect the eluate; the eluate is concentrated and dried to obtain 110.1 g of total flavonoids of Senecio Shuanghua. After UV detection, the content of total flavonoids in Shuanghua Senecio is 78.9%.

Embodiment 2

[0020] Dry the total flavonoids of Shuanghua Senecio at 60°C to obtain coarse powder; place 1000g of Shuanghua Senecio powder in a microwave-ultrasonic device, add 3L of 70% ethanol solution, set the ultrasonic 500W to normal, and the microwave power to be 600W, extracted for 2 hours, filtered, and the filtrate was concentrated under reduced pressure to obtain a concentrated solution; the concentrated solution was added to the AB-8 macroporous adsorption resin column, first eluted with distilled water of 2 times the column volume, and then 65% of the 4 times column volume Eluted with ethanol, collected the eluate; concentrated the eluate and dried to obtain 114.8 g of total flavonoids of Senecio Shuanghua. After UV detection, the content of total flavonoids in Shuanghua Senecio is 81.2%.

Embodiment 3

[0022] Dry the total flavonoids of Shuanghua Senecio at 60°C to obtain coarse powder; place 1000g of Shuanghua Senecio powder in a microwave-ultrasonic device, add 5L of 75% ethanol solution, set the ultrasonic 500W to normal, and the microwave power to be 600W, extract for 2.5h, filter, and concentrate the filtrate under reduced pressure to obtain a concentrated solution; add the concentrated solution to the XDA-1 macroporous adsorption resin column, first elute with 3 times the column volume of distilled water, and then use 70% of 5 times the column volume The ethanol was eluted, and the eluate was collected; the eluate was concentrated and dried to obtain 113.2 g of total flavonoids of Senecio Shuanghua. According to UV detection, the content of total flavonoids in Shuanghua Senecio is 83.6%.

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a method of preparing senecio dianthus franch total flavonoids and applications of the total flavonoids. The method includes a) drying senecio dianthus franch at 60 DEG C, and crushing to obtain crude powder, b) performing microwave-ultrasonic wave extraction, c) purifying with macroporous adsorptive resin, eluting with ethanol and collecting eluates, and d) concentrating and drying to obtain the total flavonoids. Pharmacodynamic evaluation proves that the extract has good oxidation resistance and obvious effects, can be used for preparing antioxidant medicines and has advantages of obvious curative effects, using convenience, and the like.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a preparation method and application of total flavonoids of Senecio bisflora. Background technique [0002] Free radicals are intermediate metabolites of various biochemical reactions in human life activities. Cells generate free radicals during normal metabolic processes, or when exposed to high-energy radiation, hyperbaric oxygen, drugs, cigarette smoke, and photochemical air pollution. [0003] Studies have shown that the process of free radicals from generation to decay is the process of electron transfer. In the living system, the transfer of electrons is the most basic movement, and oxygen has a strong ability to obtain electrons. Therefore, many chemical reactions in organisms are related to oxygen. Studies have found that the free radicals that damage human health are almost all related to those oxygen-containing substances with strong activity, and the free radicals...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P39/06
CPCA61K36/28A61K2236/333A61K2236/51A61K2236/55
Inventor 杨成东
Owner NANJING ZELANG MEDICAL TECH
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