Method for simulating tumor cell state through Boolean network

Abstract

The embodiment of the invention discloses a method for simulating the tumor cell state through a Boolean network. The method comprises the steps that continuous expression spectrum data of a biological sample gene is acquired through a gene chip collecting technique, and an initial gene regulatory network is constructed according to the continuous expression spectrum data; deletion regulation is conducted on the initial gene regulatory network on the basis of the preset gene relevance to obtain a related gene regulatory network, and the related gene regulatory network is calculated through a Boolean function to obtain a single attractor of the related gene regulatory network; the regulatory range of a target gene in the initial gene regulatory network is determined and converted into an attractor of a compound Boolean function according to the single attractor of the related gene regulatory network, and then the converted attractor and a cell attractor are matched to determine the tumor cell state. According to the method, an overall understanding on the tumor gene can be achieved, tumors are quickly identified, and a powerful theoretical framework is provided for tumor treatment research.

Description

technical field [0001] The invention relates to the technical field of systems biology research, in particular to a method for simulating the state of tumor cells through a Boolean network. Background technique [0002] Gene network studies biological systems from the molecular level, which is an interactive network formed by DNA, RNA, protein and metabolic intermediates in cells involved in gene regulation. Gene network research expects to fully reveal the function and behavior of the genome from a systematic perspective, which will help to explain the life process in detail at the genome level, so as to achieve the goal of systematically explaining cell activities and life activities. [0003] Existing methods for identifying the state of tumor cells include histopathological examination and cytological examination. [0004] In the histopathological examination method, the pathological tissue biopsy examination must take the tumor tissue to make a section, and observe the...

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Problems solved by technology

It takes 5 to 6 days to get the result if the paraffin embedding technique is used from the material collection to the observation section; however, the preliminary result can be obtained in only 20 minutes if the frozen section examination is used, but the accuracy is slightly poor, and sometimes only cancer can be obtained. diagnosis results, but cannot make judgments on the degree of differentiation, etc.

[0005] In the cytology method, cancer cells are mainly found in the patient's secretions, but the tumor is only identified from the cell, and the understanding of the entire tumor is very one-sided.

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