Composite antibacterial agent based on fluorescent conjugated polymer and up-conversion nanomaterial and its application method

Abstract

The invention discloses a composite antibacterial agent based on a fluorescent conjugated polymer and an upconversion nanometer material and a using method thereof. The composite antibacterial agent is a mixture of polyacrylic acid modified beta-NaYF4:Yb,Tm and a water soluble cation conjugated polymer based on the mass ratio of 1:(0.005-0.5), wherein polyacrylic acid modified beta-NaYF4:Yb,Tm serves as the energy provider, the water soluble cation conjugated polymer serves as the energy receiver, and polyacrylic acid modified beta-NaYF4:Yb,Tm and the water soluble cation conjugated polymer can generate an obvious synergistic effect. When 980 nm near-infrared light serves as an excitation light source to excite polyacrylic acid modified beta-NaYF4:Yb,Tm, energy is transferred onto the water soluble cation conjugated polymer through fluorescence resonance energy transfer and the conjugated polymer is excited at the same time, and a remarkable bactericidal effect is realized by means of singlet oxygen or active oxygen matter generated by the conjugated polymer. A new platform is provided for treating deep-tissue bacterial infection, and a new treatment effect is provided for bacterial drug resistance.

Description

technical field [0001] The invention belongs to the technical field of photosensitive sterilization, and in particular relates to a composite antibacterial agent based on fluorescent conjugated polymers and up-conversion nanomaterials and a use method thereof. Background technique [0002] In recent years, the emergence of bacterial resistance has seriously endangered public health. In order to solve this problem, researchers have been making active efforts in the research of new antibacterial drugs and new antibacterial methods. Since photodynamic therapy (PDT) is an effective method for treating bacterial infections, it has received extensive attention. Conjugated polymers are good PDT photosensitizers with high antibacterial properties. However, although the conjugated polymers designed and synthesized have good antibacterial effects, most of them are excited by white light and cannot deal with bacterial infections in deep tissues. Studies have found that the most promin...

AI Technical Summary

Problems solved by technology

Conjugated polymers are good PDT photosensitizers with high antibacterial properties. However, although the currently designed and synthesized conjugated polymers have good antibacterial effects, most of them are excited by white light and cannot deal with bacterial infections in deep tissues.

Studies have found that the most prominent advantages of upconversion nanomaterials are the use of infrared excitation, strong tissue penetration, and low fluorescence background, but they are not ideal photosensitizers.

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