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Pharmaceutical composition with sedative and hypnotic effects and preparation method thereof

A technology of sedative hypnosis and composition, which is applied in the field of medicine, can solve problems such as sedative hypnotic effects that have not yet been seen, and achieve excellent sedative hypnotic effects, prolong sleep time, and reduce autonomous activities.

Inactive Publication Date: 2016-09-28
ZHONGSHAN FLASHLIGHT POLYTECHNIC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] So far, there is no report on the combined use of Agarwood leaves, Ganoderma lucidum and Gynostemma pentaphyllum to exert sedative and hypnotic effects

Method used

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  • Pharmaceutical composition with sedative and hypnotic effects and preparation method thereof
  • Pharmaceutical composition with sedative and hypnotic effects and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 pharmaceutical composition mixture of the present invention

[0024] Add 100g of Agarwood leaves, 50g of Ganoderma lucidum, and 50g of Gynostemma pentaphyllum, add 2 times the volume of water to soak for 30 minutes, decoct with 6 to 8 times the volume of water each time, decoct twice, each time for 30 to 60 minutes, combine the decoction, Filter and concentrate to about 1000ml.

Embodiment 2

[0025] The preparation of embodiment 2 pharmaceutical composition granules of the present invention

[0026] Add 100g of Agarwood leaves, 50g of Ganoderma lucidum, and 50g of Gynostemma pentaphyllum, add 2 times the amount of water to soak for 30 minutes, decoct with 6 to 8 times the volume of water each time, decoct twice, each time for 30 to 60 minutes, combine the decoction, filter Concentrate under reduced pressure, dry by normal pressure drying, vacuum drying, or spray drying, and then pulverize to obtain dry cream powder, add dextrin and sucrose, mix well, wet granulate, dry, granulate, and pack into 100 bags, and each bag contains 2.5g to obtain sugar-containing granules. Or add other diluents and non-sugar-type sweeteners to the dry cream powder, mix and dry, granulate, and pack into 100 bags, each bag containing 2.0g, to obtain non-sugar-type granules.

Embodiment 3

[0027] The preparation of embodiment 3 pharmaceutical composition pills of the present invention

[0028] Grind 100g of Agarwood leaves, 50g of Ganoderma lucidum, and 50g of Gynostemma pentaphyllum into fine powder, sieve, and mix well. Add 190-210g of refined honey per 100g of powder to make big honeyed pills.

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Abstract

The invention discloses a pharmaceutical composition with sedative and hypnotic effects. The pharmaceutical composition is a preparation prepared from the following raw material drugs in parts by weight: 4 to 6 parts of aquilariae lignum resinatum leaf, 2 to 3 parts of lucid ganoderma and 2 to 3 parts of fiveleaf gynostemma herb. A pharmacological experiment shows that the pharmaceutical composition has good sedative and hypnotic effects and is capable of obviously shortening the fall-asleep time, prolonging the sleep time and reducing automatic action, and a new selection is provided for clinically using sedative and hypnotic drugs.

Description

technical field [0001] The invention relates to a pharmaceutical composition with sedative and hypnotic effects and a preparation method thereof, belonging to the field of medicine. Background technique [0002] The clinical manifestations of insomnia are sleep process disorder, daytime cognitive dysfunction, limbic system and its surrounding autonomic dysfunction, and other systemic symptoms such as short-term weight loss, immune function reduction, endocrine dysfunction, etc. to great pain and psychological burden. [0003] Currently, there is no specific drug for the treatment of insomnia, and sedative-hypnotics are mainly used clinically. Sedatives can make the user be in a state of tranquility or drowsiness, while hypnotics can cause similar to normal sleep. Produce anesthesia, anticonvulsant effect. The above-mentioned drugs include estazolam, triazolam, zolpidem, flunitrazepam, etc. Most of them are expensive and have potential risks such as adverse drug reactions ...

Claims

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Application Information

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IPC IPC(8): A61K36/835A61P25/20
CPCA61K36/835A61K36/074A61K36/424A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 王琼赵斌刘敬熊文明
Owner ZHONGSHAN FLASHLIGHT POLYTECHNIC
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