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Pharmaceutical composition for preventing and treating functional gastrointestinal disorder and preparation method thereof

A composition and technology for gastrointestinal diseases, applied in the field of medicine, can solve problems affecting the quality of life of patients, physical and mental health, and easy recurrence, and achieve the effects of improving symptoms, promoting bowel movement, and broad clinical application prospects

Active Publication Date: 2016-08-17
TEACHING HOSPITAL OF CHENGDU UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The therapeutic drugs of Western medicine mainly include prokinetic drugs, acid-suppressing drugs, drugs inhibiting Helicobacter pylori, antidepressants, etc. These drugs can relieve symptoms in a short period of time, but long-term use often causes many adverse reactions, and they are prone to Recurrence, seriously affecting the patient's quality of life and physical and mental health

Method used

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  • Pharmaceutical composition for preventing and treating functional gastrointestinal disorder and preparation method thereof
  • Pharmaceutical composition for preventing and treating functional gastrointestinal disorder and preparation method thereof
  • Pharmaceutical composition for preventing and treating functional gastrointestinal disorder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 pharmaceutical composition of the present invention

[0024] Prescription of original medicinal materials: Fructus aurantii 20g, Atractylodes macrocephala 20g, dried ginger 10g, betel nut 20g, perilla leaf 15g, licorice 15g.

[0025] 1. Preparation of extract: Weigh 20g of Citrus aurantii, 20g of Atractylodes macrocephala, 10g of dried ginger, 20g of betel nut, 15g of perilla leaf, and the amount of medicinal materials is 85g in total. Add the medicinal materials into a 1000ml round bottom flask in turn, add 510ml of water which is 6 times the amount of the medicinal materials, connect the condenser tube and the volatile oil extractor to start extraction, collect the volatile oil for 4 hours, and obtain 0.20ml of volatile oil for later use;

[0026] After extracting the volatile oil from the medicinal materials for 4 hours, add Zhigancao, add 6 times the amount of water of the total amount of medicinal materials, reflux extraction twice, ...

experiment example 1

[0051] Influence of volatile oil extraction parameters on the extraction amount of volatile oil in experimental example 1 medicinal material

[0052] Weigh 20g of Citrus aurantium, 20g of Atractylodes macrocephala, 10g of dried ginger, 20g of betel nut, 15g of perilla leaf, and a total of 85g of medicinal materials according to the prescription. Add medicinal materials into a 1000ml round-bottomed flask in turn, add 510ml of water which is 6 times the amount of medicinal materials, connect the condenser tube and volatile oil extractor to start extraction, add water from the upper end of the condenser tube to fill the scale part of the volatile oil detector, and overflow into the flask until the time. The volatile oil was collected with a volatile oil extractor, and the time and the amount of the collected volatile oil were recorded. The experimental results are shown in Table 1.

[0053] Table 1 The change of the collected amount of volatile oil with time

[0054]

[0055...

experiment example 2

[0063] Experimental example 2 The impact of water extraction process parameters on the content of index components in the extract

[0064] Fructus Aurantii Fructus, Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizome all contain flavonoids, so the determination of total flavonoids content is selected as the index condition for investigating water extraction process.

[0065] Weigh 4 parts of medicinal materials, each containing 20g of Fructus Fructus Aurantii, 20g of Atractylodes Rhizoma Atractylodes Rhizome, 10g of dried ginger, 20g of betel nut, 15g of perilla leaves, 85g in total, and 15g of the dregs and Zhigancao after extracting the volatile oil for 4 h...

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Abstract

The invention discloses a pharmaceutical composition for preventing and treating functional gastrointestinal disorder. The pharmaceutical composition is a preparation prepared from, by weight, 16-24 parts of fructus aurantii, 16-24 parts of raw rhizoma atractylodis macrocephalae, 8-12 parts of rhizoma zingiberis, 16-24 parts of betel nuts, 12-18 parts of folia perillae acutae and 12-18 parts of honey-fried licorice roots. Pharmacological experiments indicate that the pharmaceutical composition can obviously relieve the symptoms of mice suffering from the functional gastrointestinal disorder and has a remarkable promoting function on gastric emptying and intestine propulsion, the medicine effect is even superior to that of a commercially available drug domperidone, and the pharmaceutical composition has wide clinical application prospects.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating functional gastrointestinal diseases and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Functional gastrointestinal diseases refer to functional diseases of the digestive system that have obvious gastrointestinal symptoms but cannot be explained by organic lesions or biochemical abnormalities. In clinical practice, functional dyspepsia and functional constipation are the most common. Epidemiological surveys show that various functional gastrointestinal diseases account for 43% to 46% of the total prevalence of gastrointestinal diseases. Specific drugs for such diseases not only significantly affect the quality of life of patients after illness, but also cause quite high medical expenses. [0003] The etiology and pathogenesis of functional gastrointestinal diseases are still unclear. It is generally believed that the motil...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P1/00A61P1/10
CPCA61K36/284A61K36/484A61K36/535A61K36/752A61K36/889A61K36/9068A61K2236/331A61K2236/39A61K2236/55
Inventor 梁超陈崇利伍文彬
Owner TEACHING HOSPITAL OF CHENGDU UNIV OF T C M
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