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Application of MAPK (mitogen-activated protein kinase) signaling pathway inhibitor in preparation of PD (Parkinson's disease) treatment drug

A technology of signaling pathways and inhibitors, applied in the field of medicine, can solve the problems that can not be treated fundamentally, can not delay the degeneration of dopaminergic neurons, etc., and achieve the effect of delaying degenerative death and good curative effect

Inactive Publication Date: 2016-07-27
FUZHOU UNIV
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  • Abstract
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Problems solved by technology

But none of them can delay the degeneration of dopaminergic neurons, so they cannot fundamentally play a therapeutic role

Method used

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  • Application of MAPK (mitogen-activated protein kinase) signaling pathway inhibitor in preparation of PD (Parkinson's disease) treatment drug
  • Application of MAPK (mitogen-activated protein kinase) signaling pathway inhibitor in preparation of PD (Parkinson's disease) treatment drug
  • Application of MAPK (mitogen-activated protein kinase) signaling pathway inhibitor in preparation of PD (Parkinson's disease) treatment drug

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Embodiment Construction

[0016] In order to make the content of the present invention easier to understand, the technical solutions of the present invention will be further described below in conjunction with specific embodiments, but the present invention is not limited thereto.

[0017] The application of the MAPK signaling pathway inhibitor in the preparation of drugs for treating Parkinson's, specifically the use of the MAPK signaling pathway inhibitor in the preparation of drugs for delaying the degeneration of dopaminergic neurons.

[0018] The MAPK signaling pathway inhibitors include MEK inhibitors and ERK antagonists.

[0019] 1. U0126 ( ) on dopaminergic neurons in local brain regions

[0020] Taking 300 medflies as experimental objects, they were randomly divided into 4 experimental groups and 1 normal control group (Ctrl), 60 in each group, and each group was divided into experimental group and normal control group in parallel for the test. The four experimental groups respectively est...

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Abstract

The invention belongs to the technical field of medicine, discloses an application of a MAPK (mitogen-activated protein kinase) signaling pathway inhibitor in preparation of a PD (Parkinson's disease) treatment drug and particularly provides an application of the MAPK signal pathway inhibitor in preparation of a drug for delaying dopaminergic neuron degeneration. A product can effectively delay degenerative death of dopaminergic neurons, and the PD is treated fundamentally; the treatment effect of the drug can be realized through oral administration instead of injection, and the drug has a better curative effect on PD caused by various reasons and has great significance on treatment and healing of PD.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of MAPK signaling pathway inhibitors in the preparation of medicines for treating Parkinson's. Background technique [0002] Parkinson's disease (Parkinson's Disease, PD), also known as "parkinsonism", is a common degenerative disease of the central nervous system, mainly affecting middle-aged and elderly people. the trend of. The main symptoms of patients with Parkinson's disease are slow movement, uncontrollable tremors in hands, feet or other parts of the body, body stiffness, balance disturbance, so that they cannot take care of themselves. According to statistics, the prevalence of Parkinson's among people over 60 years old in my country is about 1.7%, with a total of more than 1 million patients, and at least 100,000 new cases are added every year. The degeneration and death of dopamine (DA) neurons in the substantia nigra of the midbrain, and...

Claims

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Application Information

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IPC IPC(8): A61K31/277A61K31/166A61K31/519A61P25/16
CPCA61K31/166A61K31/277A61K31/519A61K2300/00
Inventor 杨宇丰张西孙玲陈文锋倪世伟
Owner FUZHOU UNIV
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