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Preparation method and application of kidney nourishing and strengthening capsules

A technology for strengthening the body and invigorating the kidney is applied in the directions of capsule delivery, medical preparations containing active ingredients, and pharmaceutical formulations, which can solve the problems of backwardness, many impurities and affecting clinical application.

Inactive Publication Date: 2016-07-20
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Bushen Qiangshen Capsules. However, methods such as powdering are used. The process is rough, complicated, backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. This product is used clinically

Method used

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  • Preparation method and application of kidney nourishing and strengthening capsules

Examples

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Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: get Epimedium 225g, Fructus Rosa 135g, Fructus Cuscuta 135g, Fructus Ligustrum 135g, Fructus Ligustrum 135g, join CO in the supercritical extractor, ethanol is as entrainer, and entrainer accounts for 2% of total extraction solvent The volume percentage is 4%, the extraction pressure is 30MPa, the temperature is 30°C, the CO2 flow rate is 1m1 / g crude drug min, and the extraction time is 180min to obtain a supercritical extract, which is pulverized into fine powder, granulated, and filled into capsules. 0.5g.

Embodiment 2

[0016] Embodiment 2: get Epimedium 225g, Fructus Rosa 135g, Fructus Cuscuta 135g, Fructus Ligustrum 135g, Fructus Ligustrum 135g, join CO in the supercritical extractor, ethanol is as entrainer, and entrainer accounts for 2% of total extraction solvent The volume percentage is 6%, the extraction pressure is 15MPa, the temperature is 50°C, the CO2 flow rate is 1m1 / g crude drug min, and the extraction time is 180min to obtain a supercritical extract, which is pulverized into fine powder, granulated, and filled into capsules. 0.5g.

Embodiment 3

[0017] Embodiment 3: get Epimedium 225g, Fructus Rosa 135g, Fructus Cuscuta 135g, Fructus Ligustrum lucidum 135g, Fructus Ligustrum 135g, join CO in the supercritical extractor, ethanol is as entrainer, and entrainer accounts for 2% of total extraction solvent The volume percentage is 5%, the extraction pressure is 20MPa, the temperature is 40°C, the CO2 flow rate is 2m1 / g crude drug min, and the extraction time is 160min to obtain a supercritical extract, which is pulverized into fine powder, granulated, and filled into capsules. 0.5g.

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Abstract

The invention belongs to the field of traditional Chinese medicine preparations, and particularly provides a preparation method of kidney nourishing and strengthening capsules.The kidney nourishing and strengthening capsules are prepared by taking 225 g of herba epimedii, 135 g of fructus rosae laevigatae, 135 g of semen cuscutae, 135 g of processed fructus ligustri lucidi and 135 g of processed rhizoma cibotii as bulk pharmaceuticals through supercritical extraction, therefore, the content is greatly increased, and the dosage is decreased.The invention further provides application of the kidney nourishing and strengthening capsules in preparation of a drug for inhibiting proliferation of a human nervous myofibroblast tumor strain SHSY5Y.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of a kidney-tonifying and strengthening-body capsule. Background technique [0002] Bushen Qiangshen Capsules are recorded in the ministerial standard, and the prescription is 225g of Epimedium, 135g of Rosaceae, 135g of Dodder, 135g of Ligustrum lucidum, 135g of Dogji, the above five flavors, decoction of Epimedium, Rosa, and Cuscuta in water Second time, 4 hours for the first time, 3 hours for the second time, combine the decoction, filter, let stand for 8-12 hours, take the supernatant, concentrate to a clear liquid with a relative density of 1.16-1.18 (70-80°C). For the ointment, take Ligustrum lucidum and Glycyrrhiza chinensis and crush them into fine powder, sieve, mix well with the above-mentioned clear ointment, dry, pulverize, sieve, and pack into capsules to obtain. For epigastric tingling, acid reg...

Claims

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Application Information

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IPC IPC(8): A61K36/738A61K9/48A61P35/00
CPCA61K36/296A61K9/4841A61K36/11A61K36/39A61K36/638A61K36/738A61K2236/333A61K2236/37A61K2300/00
Inventor 赵明亮
Owner NANJING ZHENGLIANG MEDICAL TECH
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