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Chiral chromatographic stationary phase of sandwich structure and preparation method thereof

A chiral chromatography and sandwich technology, applied in chemical instruments and methods, other chemical processes, etc., can solve the problems of limited and alkali-resistant chiral selectivity, etc., achieve a wide range of raw material sources, prevent the loss of nanoparticles, and achieve high enantiometry The effect of body selectivity

Inactive Publication Date: 2016-07-06
NINGXIA UNIVERSITY
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Problems solved by technology

By loading nanoparticles on the surface of silica gel by seed growth method, and then coating a layer of polymer on the surface, it overcomes the problems of traditional bonded silica gel being not resistant to alkali and limited chiral selectivity.

Method used

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  • Chiral chromatographic stationary phase of sandwich structure and preparation method thereof
  • Chiral chromatographic stationary phase of sandwich structure and preparation method thereof
  • Chiral chromatographic stationary phase of sandwich structure and preparation method thereof

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Embodiment Construction

[0028] Such as figure 1 As shown, a chiral chromatographic stationary phase with a sandwich structure includes: a polymer layer, a nano-gold particle layer, and a silica gel core; wherein, the nano-gold particle layer is wrapped outside the silica gel core through an Au-N bond or an Au-S bond, and polymerized The material layer is the outermost layer, and the polymer layer forms a stable outer shell by physical wrapping. figure 1 The inner sphere is SiO 2 , the black solid sphere wrapped around it represents gold nanoparticles, and the outermost irregular linear layer is the polymer layer.

[0029] In this real-time method, the silica gel core has a diameter of 3-10 μm and a pore diameter of 3-20 nm. The diameter of the gold nanoparticles is 5-25nm, and the thickness of the nano-gold particle layer is 50-200nm. The material of the polymer layer is a polymer with chiral recognition ability, specifically cellulose derived from 3,5-dimethylphenylisocyanate or polysaccharide de...

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Abstract

The invention discloses a chiral chromatographic stationary phase of a sandwich structure. The chiral chromatographic stationary phase comprises a polymer layer, a nano-gold particle layer and a silica gel core, wherein the silica gel core is wrapped by the nano-gold particle layer through An-N bonds or Au-S bonds, and the polymer layer is the outermost layer and forms a stable outer layer shell by way of physical wrapping. The invention further provides a preparation method of the chiral chromatographic stationary phase of the sandwich structure. The preparation method of the chiral chromatographic stationary phase of the sandwich structure comprises the following steps: 1, preparation of gold nanoparticle sol; 2, preparation of SiO2@Au; 3, synthesis of the chiral chromatographic stationary phase of the sandwich structure. According to the chiral chromatographic stationary phase of the sandwich structure and the preparation method thereof, nanoparticles are loaded to the surface of silica gel through a layer-by-layer self-assembly method, and then the surface is coated with a layer of polymer, so that the problems that traditional bonded silica gel is not resistant to alkali, and chiral selectivity is limited are solved.

Description

Technical field: [0001] The invention relates to the technical field of normal-phase high-performance liquid chromatography stationary phase, in particular to a chiral chromatography stationary phase with a sandwich structure and a preparation method thereof. Background technique: [0002] Chirality is a common phenomenon in nature. Chirality is related to many important biological behaviors. The development of effective chiral separation technology is of great significance for the synthesis of pharmaceuticals and symmetric bodies. However, silica gel itself is unstable and easy to dissolve under alkaline conditions, which changes the retention characteristics and peak shapes of analytes. Research and development of new stationary phases that enhance the stability of silica matrix in alkaline environments and eliminate the irreversible adsorption of silanol to alkaline substances have always been the goals pursued by researchers. [0003] With the development of nanoscience...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/29B01J20/30
CPCB01J20/29B01J2220/825
Inventor 李媛媛韦嫚嫚朱楠
Owner NINGXIA UNIVERSITY
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