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Natural polymer liquid spray for wound protection

A natural polymer and wound technology, applied in medical science, bandages, pharmaceutical formulations, etc., can solve problems such as high cytotoxicity, achieve wide application prospects, and promote wound healing

Inactive Publication Date: 2016-06-29
ZHEJIANG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, high concentrations of siloxanes may exhibit high cytotoxicity

Method used

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  • Natural polymer liquid spray for wound protection
  • Natural polymer liquid spray for wound protection
  • Natural polymer liquid spray for wound protection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: the preparation and application method of liquid spray I

[0014] (1) Preparation method of liquid A: first dissolve carboxymethyl chitosan solid powder in a certain volume of water, stir to completely dissolve carboxymethyl chitosan, and slowly add a certain volume of ethanol dropwise to make the volume fraction of ethanol 50%, and the mass fraction of carboxymethyl chitosan solid powder is 1-2%; while stirring while adding dropwise, a light yellow transparent ethanol aqueous solution of carboxymethyl chitosan is obtained.

[0015] (2) Preparation method of liquid B: Dissolve γ-(2,3-glycidoxy)propyltrimethoxysilane in corresponding volume of ethanol, so that γ-(2,3-glycidoxy ) The mass fraction of propyltrimethoxysilane is 1-3%, and the mixture is evenly stirred.

[0016] (3) How to use the liquid spray: put liquid A and liquid B into spray bottles with double nozzles, then spray them onto the wound surface, and wait for less than 1 minute to form a film...

Embodiment 2

[0017] Embodiment 2: the preparation and use method of liquid spray II:

[0018] (1) The preparation method of A liquid: dissolve the carboxymethyl chitosan solid powder in a certain volume of water, stir to make the carboxymethyl chitosan dissolve completely, slowly add a certain volume of ethanol dropwise, so that the volume fraction of ethanol is 30%, and the mass fraction of the carboxymethyl chitosan solid powder is 1-2%; while stirring while adding dropwise, a light yellow transparent ethanol aqueous solution of carboxymethyl chitosan is obtained.

[0019] (2) The preparation method of B liquid: [3-(trimethoxysilyl) propyl] amine is dissolved in the ethanol of corresponding volume, makes [3-(trimethoxysilyl) propyl] amine The mass fraction is 1%, and it is evenly stirred.

[0020] (3) How to use the liquid spray: Put liquid A and liquid B into spray bottles with double nozzles, then spray them onto the wound surface, and wait for less than 1 minute to form a film S6.

Embodiment 3

[0021] Embodiment 3: the preparation and application method of liquid spray III

[0022] (1) Preparation method of liquid A: Carboxymethyl chitosan solid powder is dissolved in a certain volume of water, stirred to completely dissolve carboxymethyl chitosan, slowly add a certain volume of ethanol, so that the volume fraction of ethanol is 60 %, the mass fraction of carboxymethyl chitosan solid powder is 1-2%, and it is added dropwise while stirring to obtain light yellow transparent carboxymethyl chitosan ethanol aqueous solution.

[0023] (2) The preparation method of liquid B: dissolve 1,2-bis(triethoxysilyl)ethane in ethanol, so that the mass of 1,2-bis(triethoxysilyl)ethane The fraction is 1-3%, stir evenly.

[0024] (3) How to use the liquid spray: put liquid A and liquid B into spray bottles with double nozzles, then spray them onto the wound surface, and wait for less than 1 minute to form a film S3.

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Abstract

The invention relates to a natural polymer liquid spray for wound protection, which aims to use non-toxic natural polymer material carboxymethyl chitosan as a raw material, supplemented by a low-concentration bifunctional siloxane coupling agent , the two solutions are sprayed onto the wound surface at the same time, and through the rapid cross-linking reaction of the two, a layer of polymer film is formed within 1 min. Promote wound healing to a great extent. This novel, efficient, safe and convenient drug for skin wounds has broad application prospects in acute wound treatment.

Description

technical field [0001] The invention relates to a natural polymer liquid bandage material used in the field of medical devices and a preparation method thereof, in particular to a novel liquid spray that can rapidly coagulate blood and promote wound healing. Background technique [0002] The key to wound treatment is rapid hemostasis, pain relief, infection prevention and tissue repair. Therefore, it is a clinical need to develop an external preparation that can stop bleeding, sterilize, promote healing and is easy to use. Liquid bandage is a new type of medical product that can form a polymer film on the skin surface to quickly stop bleeding, protect skin wounds from infection, and maintain a certain humidity on the skin surface. [0003] Liquid bandages currently sold in the international market can be divided into two main types: the first category is volatile film-forming products, which usually dissolve synthetic polymers in a certain solvent, and some products also add...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0023A61L26/00A61L26/0061A61L26/0076A61L2400/04
Inventor 邬建敏陈锡胜崔瑶轩郑乐回来焱
Owner ZHEJIANG UNIV
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