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Silver nanoparticle composition for control of lung cancer and prostate cancer

A technology of prostate cancer and nano-silver, which is applied in the directions of drug combination, medical preparations containing active ingredients, inorganic active ingredients, etc., can solve the problems of no reports of prostate cancer cells and patents, etc.

Inactive Publication Date: 2016-06-08
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In short, there are currently no reports or patents related to the effect of nano-silver on H1299 and prostate cancer cells.

Method used

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  • Silver nanoparticle composition for control of lung cancer and prostate cancer
  • Silver nanoparticle composition for control of lung cancer and prostate cancer
  • Silver nanoparticle composition for control of lung cancer and prostate cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Weigh 10g longan shell powder after drying and crushing, add 50mL distilled water, heat in a 100mL beaker and filter. The resulting plant extract was added dropwise to AgNO at a ratio of 1:19 3 React in the solution, set the volume to 100mL, the final concentration of silver nitrate is 0.5mM, place it in a closed container, set the reaction temperature as 25°C, obtain nano-silver sol after reacting for 72h, centrifuge to obtain the nano-silver composition, transmission electron microscope ( TEM) The morphology of the obtained nano-silver composition observed is spherical, and the particle size range is 8-30nm. See the experimental results figure 1 .

Embodiment 2

[0017] Weigh 10g of litchi shell powder after drying and crushing, add 200mL of distilled water, heat in a 500mL beaker and filter. The resulting plant extract was added dropwise to AgNO at a ratio of 1:1. 3 React in the solution, set the volume to 100mL, the final concentration of silver nitrate is 2.0M, place in an airtight container, set the reaction temperature as 100°C, obtain nano silver sol after reacting for 3h, centrifuge to obtain nano silver composition, transmission electron microscope ( TEM) The morphology of the obtained nano-silver composition observed is spherical, and the particle size range is 12-25nm.

Embodiment 3

[0019] Dried longan shells and crushed lychee shells weighed 5g dry powder each, added 300mL distilled water and 100mL absolute ethanol, heated in a 1000mL beaker and filtered. The resulting plant extract was added dropwise to AgNO at a ratio of 1:1. 3 React in the solution, set the volume to 100mL, the final concentration of silver nitrate is 1.0M, place it in an airtight container, set the reaction temperature as 100°C, obtain the nano-silver sol after reacting for 3h, centrifuge to obtain the nano-silver composition, transmit electron microscope ( TEM) The morphology of the obtained nano-silver composition observed is spherical, and the particle size range is 18-37nm.

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Abstract

The invention provides a silver nanoparticle composition with lung cancer and prostate cancer resistant activity. The composition contains 20-500mg / kg nano-silver and pharmaceutically acceptable injection excipients (a suspending aid, a dispersing agent, a surfactant, an analgesic, a pH adjustment buffer agent, an osmotic pressure regulator, and water). In the spherical silver nanoparticle powder, the purity of silver is greater than or equal to 99%, and the particle size of silver nanoparticles is 8-75. The experimental result shows that the silver nanoparticle involved in the invention has very strong inhibitory activity on lung cancer H1299 cells and prostate cancer PC-3 cells, and can significantly inhibit H1299 tumor cell transplanted SCID mouse tumor growth in vivo. Therefore, the silver nanoparticle anticancer composition can be used as an antitumor active ingredient individually or in combination for prevention of lung cancer and prevention and treatment of prostate cancer.

Description

technical field [0001] The invention relates to a nano-silver composition capable of preventing and treating lung cancer and prostate cancer, which can be used alone or in combination as an anti-tumor active ingredient. Background technique [0002] Cancer has become the number one cause of death in humans, and the global cancer burden is currently growing at an alarming rate. According to the latest "World Cancer Report 2014" released by WHO, in 2012, there were more than 14 million new cancer cases in the world, which will increase to 19 million in 2025, 22 million in 2030, and 24 million in 2035. China bears the brunt, with 3.07 million newly diagnosed cancer cases in 2012, accounting for 21.8% of the global total, and about 2.2 million cancer deaths, accounting for 26.9% of the global cancer deaths. And in the past 20 years, cancer has shown a trend of younger age, higher morbidity and mortality. [0003] Among them, both in the world and in China, the incidence and mo...

Claims

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Application Information

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IPC IPC(8): A61K33/38A61K45/06A61P35/00
Inventor 何燕杜志云郑希马诗经江森月圆张焜方岩雄赵肃清王华倩卢宇靖黄华容
Owner GUANGDONG UNIV OF TECH
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