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Oyster calcium carbonate effervescent tablet composition and preparation method thereof

A technology of oyster calcium carbonate and effervescent tablets, which is used in drug delivery, pharmaceutical formulations, active ingredients of aluminum/calcium/magnesium, etc., can solve problems such as discomfort and hyperacidity, and achieve improved dissolution, accelerated dissolution, and improved lubrication. sexual effect

Active Publication Date: 2018-09-11
SINOPHARM SHANTOU JINSHI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In addition, the solution of existing calcium carbonate effervescent tablets is slightly acidic after flushing and effervescent. In order to completely dissolve calcium carbonate, the amount of acid source is generally slightly more than the amount of calcium carbonate. It is partially dissolved in the solution, and the pH of the effervescent solution is about 4. After taking it, it may cause hyperacidity and discomfort

Method used

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  • Oyster calcium carbonate effervescent tablet composition and preparation method thereof
  • Oyster calcium carbonate effervescent tablet composition and preparation method thereof
  • Oyster calcium carbonate effervescent tablet composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Oyster calcium carbonate effervescent tablet composition, by g, is composed as follows:

[0036]

[0037] The preparation method is as follows:

[0038] Dissolve povidone with 90wt% ethanol to prepare 920mL of 2.5wt% povidone solution; dissolve oil-soluble liquid essence with 90wt% ethanol to form 60mL of uniform essence solution;

[0039] Evenly mix the essence solution prepared above with 240mL povidone solution, then use the mixed solution to make oyster calcium carbonate into a soft material, wet granulate, dry under reduced pressure and vacuum at a temperature below 45°C, and sizing the granules to obtain 20-40 mesh Calcium carbonate alkali particles;

[0040] Sodium bicarbonate is made into a soft material with 185mL povidone solution, wet granulated, dried under reduced pressure and vacuum at a temperature below 45°C, and sized to obtain 20-40 mesh sodium bicarbonate alkali granules;

[0041] Mix the acid source and the sweetener evenly, then use the remaini...

Embodiment 2

[0044] Oyster calcium carbonate effervescent tablet composition, by g, is composed as follows:

[0045]

[0046] The preparation method is as follows:

[0047] Dissolve povidone with 90wt% ethanol to prepare 1120mL of 2.5wt% povidone solution; dissolve oil-soluble liquid essence with 90wt% ethanol to form a uniform essence solution of 60mL;

[0048] Evenly mix the essence solution prepared above with 240mL povidone solution, then use the mixed solution to make oyster calcium carbonate into a soft material, wet granulate, dry under reduced pressure and vacuum at a temperature below 45°C, and sizing the granules to obtain 20-40 mesh Calcium carbonate alkali particles;

[0049] Sodium bicarbonate is made into a soft material with 225mL of povidone solution, wet granulated, dried under reduced pressure and vacuum at a temperature below 45°C, and sized to obtain 20-40 mesh sodium bicarbonate alkali granules;

[0050] Mix the acid source and the sweetener evenly, then use the r...

Embodiment 3

[0053] Oyster calcium carbonate effervescent tablet composition, by g, is composed as follows:

[0054]

[0055] The preparation method is as follows:

[0056] Dissolve povidone with 90wt% ethanol to prepare 1000mL of 2.5wt% povidone solution; dissolve the oil-soluble liquid essence with 90wt% ethanol to form a uniform essence solution of 60mL;

[0057] Evenly mix the essence solution prepared above with 240mL povidone solution, then use the mixed solution to make oyster calcium carbonate into a soft material, wet granulate, dry under reduced pressure and vacuum at a temperature below 45°C, and sizing the granules to obtain 20-40 mesh Calcium carbonate alkali particles;

[0058] Sodium bicarbonate is made into a soft material with 200mL povidone solution, wet granulated, dried under reduced pressure and vacuum at a temperature below 45°C, and sized to obtain 20-40 mesh sodium bicarbonate alkali granules;

[0059] Mix the acid source and the sweetener evenly, then use the ...

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Abstract

The invention belongs to the field of medicine, and relates to an oyster calcium carbonate effervescent tablet composition and a preparation method thereof. The oyster calcium carbonate effervescent tablet composition is prepared from, by weight, 100 parts of oyster calcium carbonate, 180-260 parts of acid source, 50-100 parts of sodium bicarbonate, 1-10 parts of oil-soluble liquid essence, 1-3 parts of povidone and 2-45 parts of sweetening agent. The oyster calcium carbonate effervescent tablet composition can be effervesced and dissolved well, improved lubricity and bonding resistance are achieved by means of the oil-soluble liquid essence, the sticking problem in the effervescent tablet pressing process is solved, and production can be carried out in a workshop at the temperature of 30 DEG C or below and with the RH not larger than 50%. The formula composition of oyster calcium carbonate effervescent tablets is optimized, the pH value of the solution obtained after effervescing ranges from 5 to 6, and the situation that discomfort is caused by hyperacidity is avoided.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to oyster calcium carbonate effervescent tablet composition and a preparation method thereof. Background technique [0002] Calcium is one of the important elements in the human body and has very important physiological and biochemical functions. Calcium is not only the main substance that constitutes bones, but also participates in the metabolism of bones, and is necessary to maintain nerve and muscle functions, and also plays an important role in maintaining normal heart, kidney, lung and blood coagulation functions, as well as the permeability of cell membranes and capillaries It can also regulate the secretion and storage of neurotransmitters and hormones, the uptake and utilization of amino acids, vitamin B 12 absorption etc. The important mechanism for the living cells of the human body to obtain energy is the transmembrane movement of calcium. The calcium content of the normal cell me...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/10A61K9/46A61K47/44A61K47/32
CPCA61K9/0007A61K9/2013A61K9/2027A61K33/10
Inventor 陈智强陈丹瑾陈美清陈茂棠陈振华张小华陈榕
Owner SINOPHARM SHANTOU JINSHI PHARMA CO LTD
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