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Composition for treating gastric ulcer complicated with gastrointestinal bleeding and preparation method thereof

A technology for gastrointestinal bleeding and composition, applied in the field of medicine, can solve the problems not mentioned, and achieve the effects of reducing gastric ulcer index, shortening bleeding time and coagulation time

Active Publication Date: 2019-03-29
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application disclosed in this patent is to treat peptic ulcer diseases and ulcers caused by Helicobacter pylori, duodenal ulcers, acute and chronic gastritis, bacillary dysentery, enteritis, diarrhea diseases or further for the preparation of drugs for the treatment of peptic ulcers, But it does not mention that the drug has the effect of treating gastric bleeding or treating gastric ulcer combined with gastric bleeding

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: the preparation of composition of the present invention

[0035](1) Weigh 2 kg of Panax notoginseng, crush it into a 40-mesh coarse powder, add 20 times the weight of medicinal materials and 75% ethanol to reflux for extraction twice, each time for 3 hours, filter, and combine the filtrates to obtain a notoginseng alcohol extract; add medicinal materials to the dregs 12 times the weight of water, reflux extraction twice, each time for 1.5h, filter, combine the filtrates to obtain the Sanqi water extract; combine the Sanqi alcohol extract and the water extract, concentrate under reduced pressure at 80°C, and dry to obtain the Sanqi dry immersion paste; Panax notoginseng dry extract, add a small amount of 70% ethanol to dissolve, pass through D101 macroporous adsorption resin column chromatography, first elute with 2BV deionized water, discard the eluent; then elute with 4BV 75% ethanol, wash The removal rate is 3 BV / h, the ethanol eluent is combined, the so...

Embodiment 2

[0038] Embodiment 2: the preparation of composition of the present invention

[0039] (1) Weigh 2 kg of Panax notoginseng, crush it into a 40-mesh coarse powder, add 15 times the weight of the medicinal material and 70% ethanol to reflux for extraction twice, each time for 1 hour, filter, and combine the filtrates to obtain the notoginseng alcohol extract; the medicinal residue is then added to the medicinal material reflux extraction with 10 times the weight of water for 2 times, each time for 1 hour, filter, and combine the filtrates to obtain the water extract of Sanqi ; Radix Notoginseng dry extract, add a small amount of 70% ethanol to dissolve, pass through D101 macroporous adsorption resin column chromatography, first elute with 1BV deionized water, discard the eluent; then elute with 2BV 70% ethanol, elute The speed is 1 BV / h, the ethanol eluent is combined, the solvent is recovered, and dried at 80°C to obtain the total saponins of Panax notoginseng;

[0040] (2) Aft...

Embodiment 3

[0042] Embodiment 3: the preparation of composition of the present invention

[0043] (1) Weigh 2 kg of Panax notoginseng, crush it into a 40-mesh coarse powder, add 25 times the weight of the medicinal material, 70% ethanol, reflux and extract 3 times, each time for 3 hours, filter, and combine the filtrates to obtain the notoginseng alcohol extract; add the medicinal material to the dregs Reflux extraction with 15 times the weight of water for 2 times, each time for 2 hours, filter, combine the filtrates to obtain the Sanqi water extract; combine the Sanqi alcohol extract and the water extract, concentrate under reduced pressure at 80°C, and dry to obtain the Sanqi dry extract ; Panax notoginseng dry extract, add a small amount of 70% ethanol to dissolve, pass through D101 macroporous adsorption resin column chromatography, first elute with 4BV deionized water, discard the eluent; then elute with 3BV 70% ethanol, elute The speed is 1 BV / h, the ethanol eluent is combined, the...

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PUM

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Abstract

The invention relates to a composition for treating a gastric ulcer combined gastrointestinal bleeding. The composition comprises the following active components in parts by weight: 8-25 parts of ginsenoside Re, 10-30 parts of ginsenoside Rg3 and 5-20 parts of ginsenoside Rh1. The composition has the effects of obviously improving the gastric mucosal lesion and gastric mucosal lesion, promoting the blood coagulation and stopping bleeding, and is capable of effectively treating and / or preventing gastrointestinal diseases of the gastric ulcer combined gastrointestinal bleeding and the like.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a composition for treating gastric ulcer complicated with gastrointestinal bleeding and a preparation method thereof. Background technique [0002] In recent years, with the continuous improvement of people's living standards, great changes have taken place in people's lifestyles, accompanied by an obvious upward trend in the incidence and prevalence of gastrointestinal diseases. Gastric ulcer is a common and frequently-occurring disease in gastrointestinal system diseases. This disease is easily combined with gastric bleeding. Clinically, it is mainly manifested as stomach pain, bloating, diarrhea, blood in the stool, hematemesis and other symptoms. In traditional Chinese medicine, it belongs to " epigastric pain", "fullness" and other categories. [0003] In terms of etiology and pathogenesis, the occurrence of gastrointestinal diseases such as gastric ulcer and gastric bleeding is mos...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K36/258A61P1/00A61P1/04A61P7/04
CPCA61K9/1652A61K9/2059A61K9/4866A61K31/704A61K36/258A61K2236/331A61K2236/333A61K2236/39A61K2236/55A61K2300/00
Inventor 谭喜梅林艳英邓裕彦严灿梅招丽君杨北妮黄源春
Owner GUANGXI WUZHOU PHARMA GRP
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