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Xanthoceras sorbifolia bunge flavone extract as well as preparation method, quality detection method and application thereof

A technology of Fructus radix and its extract is applied in the field of flavonoid flavonoids and its preparation, and can solve the problems of low content of active ingredients, many impurities, and inability to achieve the enrichment of active ingredients.

Inactive Publication Date: 2016-05-04
董玉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Yet the xanthophyll flavonoids extract that obtains in the above-mentioned scheme is only the crude extract that extracts by ethanol, and wherein impurity is more, and active ingredient content is low, can't reach the enrichment of effective active ingredient, and wherein to xanthophylla The quality inspection of the extraction only detects the content of rutin, and does not measure the content of other active ingredients in the extract of sorbiflorium flavone. Quality Controllability

Method used

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  • Xanthoceras sorbifolia bunge flavone extract as well as preparation method, quality detection method and application thereof
  • Xanthoceras sorbifolia bunge flavone extract as well as preparation method, quality detection method and application thereof
  • Xanthoceras sorbifolia bunge flavone extract as well as preparation method, quality detection method and application thereof

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Embodiment 1

[0168] The preparation method of Xanthophyllum flavonoids extract described in the present embodiment comprises the following steps:

[0169] Take 1.0 kg of decoction pieces of Xanthomonas xanthus, add 10 L of ethanol solution with a volume concentration of 50% and a pH value of 2.5, and extract 3 times under reflux, and extract for 1 hour each time, recover the solvent under reduced pressure to obtain a crude extract, add a certain volume of water to disperse Dissolve so that the volume ratio of the crude extract weight to the dispersed solution is 1:3.5, pass through 7.5L of S-8 macroporous adsorption resin, the adsorption flow rate is 2Bv / h, the resin column diameter-to-height ratio is 1:10, wash with water Remove 1.5 times the resin volume for impurity removal, the impurity removal flow rate is 2Bv / h, elute 8 times the resin volume with a volume concentration of 50% ethanol solution, the elution flow rate is 2Bv / h, collect the volume concentration 50% ethanol eluate, and re...

Embodiment 2

[0172] The preparation method of Xanthophyllum flavonoids extract described in the present embodiment comprises the following steps:

[0173] Take 0.5 kg of decoction pieces of Xanthomonas xanthus, add 15 L of ethanol solution with a volume concentration of 70% and a pH value of 10, perform ultrasonic extraction for 3 times, each time for 1.5 hours, and recover the solvent under reduced pressure to obtain a crude extract, add a certain volume of Disperse and dissolve in water so that the ratio of the weight of the crude extract to the volume of the solution after dispersion is 1:5, pass through 10L of D4020 macroporous adsorption resin, the adsorption flow rate is 2Bv / h, the ratio of diameter to height of the resin column is 1:6, and elute with water 2 times the resin volume for impurity removal, the impurity removal flow rate is 4Bv / h, 8 times the resin volume is eluted with a volume concentration of 50% ethanol, the elution flow rate is 1Bv / h, the volume concentration 50% eth...

Embodiment 3

[0176] The preparation method of Xanthophyllum flavonoids extract described in the present embodiment comprises the following steps:

[0177] Take 1.5 kg of decoction pieces of Xanthomonas xanthus medicinal material, add 6 L of ethanol solution with a volume concentration of 80% to reflux and extract twice, extract for 3 hours each time, recover the solvent under reduced pressure to obtain a crude extract, add a certain volume of water to disperse and dissolve, so that the The ratio of the weight of the crude extract to the volume of the solution after dispersion is 1:8, through 8L of HPD400 macroporous adsorption resin, the adsorption flow rate is 1Bv / h, the ratio of diameter to height of the resin column is 1:7, and water is eluted to remove impurities by 4 times the volume of the resin , the impurity removal flow rate is 6Bv / h, 7 times the resin volume is eluted with a volume concentration of 80% methanol solution, the elution flow rate is 9Bv / h, the volume concentration of ...

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Abstract

The invention provides a xanthoceras sorbifolia bunge flavone extract as well as a preparation method, a quality detection method and application thereof. The total sum of percentage contents of total flavonoid ingredients in the xanthoceras sorbifolia bunge flavone extract is 10-99%, wherein the total flavonoid ingredients comprise dihydromyricetin, myricetin, quercetin, rutin, dihydroquercetin, xanthocerin and cachou extract, so that content of effective ingredients in xanthoceras sorbifolia bunge is greatly increased, and the defects that the content of the effective ingredients in the xanthoceras sorbifolia bunge flavone extract prepared in the prior art is low, many impurities are contained and enrichment of effective active ingredients is not realized are overcome.

Description

technical field [0001] The technical field of the pharmaceutical extract of the present invention, in particular relates to an extract of xanthophyllin and its preparation method, quality detection method and application. Background technique [0002] Xanthoceressorbifolia Bunge is the dry xylem of the stem or branch of Xanthoceressorbifolia Bunge. Xanthoceressorbifolia Bunge is a commonly used medicinal material in Mongolian medicine, and the name of the Mongolian medicine is Xila Sendeng. Shrubs or trees, born in hillsides and valleys, distributed in Liaoning, Hebei, Shaanxi and other provinces of my country, mainly produced in Inner Mongolia, are rare woody oil crops unique to my country. As a medicine of Mongolian medicine, it was first recorded in the second part of Theoretical Drugs of "Four Medical Codes", and it was recorded in related works such as herbal medicine and prescriptions of Mongolian medicine. "Mongolian Pharmacy" describes Wenguanmu like this: "It taste...

Claims

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Application Information

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IPC IPC(8): A61K36/77A61P29/00A23L33/00G01N30/88G01N21/31
Inventor 董玉
Owner 董玉
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