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Uses of calenduloside E in preparation of anti-tumor medicines

An anti-tumor drug, the technology of calendulaside, applied in the field of medicine, can solve the problem that calendulaside E has not yet inhibited B16F10 melanoma cells, and achieve the effect of inhibiting adhesion and reducing tumor weight

Inactive Publication Date: 2016-05-04
INST OF SPECIAL ANIMAL & PLANT SCI OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far, there is no report that calendulaside E inhibits B16F10 melanoma cells

Method used

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  • Uses of calenduloside E in preparation of anti-tumor medicines
  • Uses of calenduloside E in preparation of anti-tumor medicines
  • Uses of calenduloside E in preparation of anti-tumor medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043]Preparation of calendula glycoside E capsules

[0044] Monomer calendula glycoside E 20g, medicinal starch 10g, wet granulated with 80% ethanol, granulated, dried, packed into capsules, 0.2g per capsule.

Embodiment 2

[0046] Preparation of platycodon saponin D tablet

[0047] Monomer calendulaside E 20g, starch 10g, dextrin 20g, appropriate amount of 50% ethanol, granulated, granulated, dried, compressed into tablets, 0.2g per tablet.

Embodiment 3

[0049] Preparation of Calendula E Dropping Pills

[0050] Heat 60g of polyethylene glycol 4000 on a water bath for 1 hour to obtain a melt, add 20g of Platycodon saponin D monomer, and keep it in a heat preservation pot at 65°C for about 1 hour. Dropping with a dropping pill machine, the dropping speed is about 110 pills / min, the dropping temperature is 65-70°C, cooled in liquid paraffin, the weight of the prepared pill is about 60mg, and the weight of the pill after drying according to the regulations is about 40-45mg.

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Abstract

The invention provides uses of calenduloside E in preparation of anti-tumor medicines. Experiments about influences of the calenduloside E on activity of B16F10 melanoma cells prove that the calenduloside E can inhibit activity of tumor cells. Experiments about influences of the calenduloside E on activity of human umbilical vein endothelial cells (HUVECs) and lumen formation experiments prove that the calenduloside E can inhibit activity of vascular endothelial cells and inhibit lumen formation capability of the vascular endothelial cells. Experiments about influences of calenduloside E administration on growth of B16F10 melanoma cells in mice prove that the calenduloside E can inhibit in-vivo tumor cell growth and has anti-tumor activity.

Description

technical field [0001] The invention discloses a use of calendula glycoside E in the preparation of antitumor drugs, which is a new medical application of calendula glycoside E and belongs to the technical field of medicine. Background technique [0002] With the changes of human living environment, living standards and lifestyles and the advancement of medicine, the spectrum of diseases has undergone significant changes, general infectious diseases have been gradually controlled, and malignant tumors have become increasingly common and seriously threaten human life and quality of life. one of the major diseases. At present, cancer has become the second leading cause of human death. Finding effective anticancer drugs and methods to completely conquer cancer is an important research topic in the world medical community. At present, Western medicine has its own disadvantages in the treatment of tumors. Surgical therapy is mainly aimed at early or local tumors, and the tre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P35/00
CPCA61K9/1652A61K9/2031A61K9/2059A61K31/704
Inventor 郑斯文王英平肖盛元王佳郭强
Owner INST OF SPECIAL ANIMAL & PLANT SCI OF CAAS
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