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Synthesis method for 2,2-dimethyl-5-(4-bromophenyl)-6-amino-3-hexanone

A synthesis method, technology of bromophenyl, applied in the field of synthesis of 2,2-dimethyl-5--6-amino-3-hexanone, can solve backward technology, difficult to manage, and no ideal industrial production method And other issues

Inactive Publication Date: 2016-04-06
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] 2,2-Dimethyl-5-(4-bromophenyl)-6-amino-3-hexanone is an organic chemical intermediate, widely used in the synthesis of medicines and pesticides, and has a wide range of uses. The pesticides synthesized with it There are dozens of varieties, and the new fungicide manufactured has unique functions, and is a promising fungicide and pesticide intermediate, but 2,2-dimethyl-5-(4-bromophenyl)-6 -Amino-3-hexanone has never had an ideal industrial production method
The traditional production of 2,2-dimethyl-5-(4-bromophenyl)-6-amino-3-hexanone has backward technology, long process, low yield, large amount of three wastes, and is difficult to treat

Method used

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  • Synthesis method for 2,2-dimethyl-5-(4-bromophenyl)-6-amino-3-hexanone

Examples

Experimental program
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Effect test

example 1

[0015] Measure 0.2mol pinacolone, 3g sodium hydroxide, pour it into 500mL ethanol solution with a mass concentration of 80%, then transfer it into a water bath, heat it to 50°C, place it on a magnetic stirrer, and stir at a speed of 200r / min 20min; Pour 0.2mol of p-bromobenzaldehyde into a 100mL beaker, add 50mL of ethanol solution with a mass concentration of 80%, stir evenly with a glass rod, add it dropwise to the above mixture, control the drop rate, Make it dropwise within 30min, and continue to stir for 40min; put the above mixture into a rotary evaporator, remove the ethanol by rotary evaporation, then place it in an ice-water bath, and let the ice bath stand for 1h until the precipitate no longer separates out. The material was dried and used for later use; 15mmol of the obtained precipitate was mixed with 50mL of absolute ethanol and placed in a 100mL beaker, stirred and dissolved with a glass rod for 10min, then 70mmol of nitromethane and 1mmol of potassium carbonate ...

example 2

[0017] Measure 0.2mol of pinacolone and 4g of sodium hydroxide, pour it into 500mL of ethanol solution with a mass concentration of 80%, then transfer it into a water bath, heat it to 60°C, place it on a magnetic stirrer, and stir at a speed of 250r / min 25min; Pour 0.2mol p-bromobenzaldehyde into a 100mL beaker, add 60mL of ethanol solution with a mass concentration of 80%, stir evenly with a glass rod, add it dropwise to the above mixture, control the drop rate, Make it dropwise within 35min, and continue to stir for 50min; put the above mixture into a rotary evaporator, remove the ethanol by rotary evaporation, then place it in an ice-water bath, and let it stand in the ice bath for 1h until the precipitate no longer precipitates. 18mmol of the obtained precipitate was mixed with 55mL of absolute ethanol and put into a 100mL beaker, stirred and dissolved with a glass rod for 15min, then 75mmol of nitromethane and 2mmol of potassium carbonate were added, and the temperature wa...

example 3

[0019] Measure 0.3mol pinacolone, 5g sodium hydroxide, pour it into 500mL ethanol solution with a mass concentration of 80%, then transfer it into a water bath, heat it up to 70°C, place it on a magnetic stirrer, and stir at a speed of 300r / min 30min; Pour 0.3mol of p-bromobenzaldehyde into a 100mL beaker, add 70mL of ethanol solution with a mass concentration of 80%, stir evenly with a glass rod, add it dropwise to the above mixture, control the drop rate, Make it dropwise within 40min, and continue to stir for 60min; put the above mixture into a rotary evaporator, remove the ethanol by rotary evaporation, then place it in an ice-water bath, and let it stand for 2h in the ice bath until the precipitate no longer precipitates. 20mmol of the obtained precipitate was mixed with 60mL of absolute ethanol and put into a 100mL beaker, stirred and dissolved with a glass rod for 20min, then 80mmol of nitromethane and 3mmol of potassium carbonate were added, and the temperature was heat...

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Abstract

The invention relates to a synthesis method for a compound, in particular to a synthesis method for 2,2-dimethyl-5-(4-bromophenyl)-6-amino-3-hexanone. According to the method, pinacolone and sodium hydroxide serve as raw materials and react with bromobenzaldehyde, an ethanol solution is added dropwise, an ice-water bath is conducted on precipitate, the precipitate reacts with nitromethane, finally, ammonium hydroxide is added for ammoniation, drying is conducted after ice segregation, and 2,2-dimethyl-5-(4-bromophenyl)-6-amino-3-hexanone is obtained. According to the method, reaction conditions are mild, and the yield is high.

Description

technical field [0001] The invention relates to a method for synthesizing a compound, and a method for synthesizing 2,2-dimethyl-5-(4-bromophenyl)-6-amino-3-hexanone. Background technique [0002] 2,2-Dimethyl-5-(4-bromophenyl)-6-amino-3-hexanone is an organic chemical intermediate, which is widely used in the synthesis of medicines and pesticides, and has a wide range of uses. There are dozens of varieties, and the new fungicides produced have unique functions and are promising intermediates for bactericidal and pesticides, but 2,2-dimethyl-5-(4-bromophenyl)-6 -Amino-3-hexanone has no ideal industrial production method. The traditional production process of 2,2-dimethyl-5-(4-bromophenyl)-6-amino-3-hexanone is backward, the process is long, the yield is low, the amount of three wastes is large, and it is difficult to treat. SUMMARY OF THE INVENTION [0003] The invention provides a synthesis method of 2,2-dimethyl-5-(4-bromophenyl)-6-amino-3-hexanone with mild reaction c...

Claims

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Application Information

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IPC IPC(8): C07C225/16C07C221/00
CPCC07C45/74C07C45/69C07C221/00
Inventor 陈兴权
Owner CHANGZHOU UNIV
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