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Drug composition for treating benign prostatic hyperplasia and application thereof

A technology of prostatic hyperplasia and composition, applied in the field of medicine, can solve the problems such as no literature report of anti-prostatic hyperplasia yet

Inactive Publication Date: 2016-04-06
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] By searching domestic and foreign literature, it is found that Q808 is currently reported to have anti-epileptic, anti-inflammatory, anti-bacterial, and anti-hypertensive biological activities, but there is no literature report on the compound’s anti-prostatic hyperplasia

Method used

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  • Drug composition for treating benign prostatic hyperplasia and application thereof
  • Drug composition for treating benign prostatic hyperplasia and application thereof
  • Drug composition for treating benign prostatic hyperplasia and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0018] The present invention is further described in detail by the description of the effect test example below:

[0019] Sixty male Wistar rats were randomly divided into five groups, 12 in each group, namely blank group, model group, positive control group, Q808 high-dose group and low-dose group. After the rats were fed adaptively for 5 days, the rats in the blank group underwent sham operation, and the rats in the other four groups underwent castration, and the rats were fed adaptively for 7 days. The rats in the blank group were subcutaneously injected with 10 mg / (kg·d) of normal saline, and the rats in the other groups were subcutaneously injected with 10 mg / (kg·d) of testosterone propionate for 10 consecutive days. Subcutaneously inject the original dose of testosterone propionate every other two days (the blank group is injected with normal saline), at the same time, the rats in the blank group and the model group are given 10ml / (kg·d) by intragastric administration of...

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PUM

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Abstract

The invention discloses a drug composition for treating benign prostatic hyperplasia and application thereof. The drug composition is prepared from active ingredients and an auxiliary material, and the active ingredients include 6-(4-chlorophenoxy)-tetrazolo-[5,1-alpha] phthalazine. The drug composition can treat benign prostatic hyperplasia by improving the gonadal hormone levels in vivo.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a pharmaceutical composition for treating benign prostatic hyperplasia. Background technique [0002] Prostatic hyperplasia (BPH) is a common progressive disease in middle-aged and elderly men, and its onset usually begins around the age of 40. According to statistics, the incidence rate of men over 45 years old is 42%-90%, and it increases year by year with age, and it can be as high as 70%-80% by the age of 80. The main symptoms are nocturia, urgency, frequent urination, dysuria, etc. This disease has seriously affected the quality of life and physical and mental health of middle-aged and elderly people. The treatment of BPH is mainly divided into surgical treatment and drug treatment. Surgical resection was once considered to be the first choice for the radical cure of BPH. However, the advanced age of the patients often makes the surgical treatment have certai...

Claims

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Application Information

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IPC IPC(8): A61K31/5025A61P13/08
CPCA61K31/5025
Inventor 高建刚王荃邱志磊
Owner QINGDAO MUNICIPAL HOSPITAL
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