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Anhydroicaritin oral preparation and preparation method thereof

A technology for oral preparations of icariin, which is applied in the field of oral preparations of icariin and its preparation, can solve the problems of complicated process, potential safety hazards, and limited improvement, and achieve the effect of simple preparation process and high safety

Active Publication Date: 2016-03-23
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, whether it is a microemulsion or a liposome, the process is more complicated
Microemulsions contain a large amount of surfactants, which bring safety hazards to human medicine; lysophospholipids exist in phospholipids in liposomes, and phospholipid oxidation also poses safety hazards
Of course, in order to improve the solubility, means such as micro-powder treatment can also be carried out, but the improvement is limited.

Method used

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  • Anhydroicaritin oral preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Icariin 1g

[0020] Diethylene glycol monoethyl ether 20g

[0021] Povidone 5g

[0022] Preparation Process:

[0023] The prescribed amount of icariin and povidone is weighed, added to the prescribed amount of diethylene glycol monoethyl ether, stirred to dissolve, and then the solution is filtered and then divided into oral liquid bottles.

Embodiment 2

[0025] Icariin 1g

[0026] Diethylene glycol monoethyl ether 60g

[0027] Povidone 15g

[0028] Preparation Process:

[0029] The prescribed amount of icariin and povidone is weighed, added to the prescribed amount of diethylene glycol monoethyl ether, stirred to dissolve, and then the solution is filtered and then divided into oral liquid bottles.

Embodiment 3

[0031] Icariin 1g

[0032] Diethylene glycol monoethyl ether 40g

[0033] Povidone 10g

[0034] Preparation Process:

[0035] The prescribed amount of icariin and povidone is weighed, added to the prescribed amount of diethylene glycol monoethyl ether, stirred to dissolve, and then the solution is filtered and then divided into oral liquid bottles.

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Abstract

The invention discloses an anhydroicaritin oral preparation and a preparation method thereof. The anhydroicaritin preparation contains diethylene glycol monoethyl ether and povidone. Compared with the prior art, liquid medicine is diluted into water, the solution is clear and transparent, the stability is good, the particle size range is 20-100 nm, the preparation technology is simple, and safety is high.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an oral preparation of icarigenin and a preparation method thereof. Background technique [0002] Cyclic icariin (hereinafter referred to as RICT in this application) is a flavonoid compound obtained by desugaring and forming a ring after the main component icariin in Epimedium decoction pieces is hydrolyzed by acid, and its structural formula as follows: [0003] [0004] Icarigenin is extremely fat-soluble, slightly soluble in dichloromethane and ethyl acetate, almost insoluble in methanol, absolute ethanol and water, and almost insoluble or insoluble in different pH buffers. Its extremely low solubility will inevitably affect the absorption of drugs. [0005] CN10513388A discloses an icariin microemulsion preparation, which is prepared by dissolving icariin in oil, adding an emulsifier, a co-emulsifier and water, and the particle size is 10-100nm. [0006] C...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/48A61K31/352A61K47/32A61K47/08
Inventor 赵志全郝贵周赵星星陈小伟
Owner SHANDONG NEWTIME PHARMA
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