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Bulk drug phillyrin quality detection method

A quality detection method, the technology of forsythin, applied in the direction of measuring devices, material separation, analysis of materials, etc., can solve the problems of weak innovation and market competitiveness, and difficulty in the circulation of the world's pharmaceutical market

Active Publication Date: 2016-03-02
富力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, compound preparations of traditional Chinese medicine are difficult to circulate in the world pharmaceutical market due to weak innovation and market competitiveness.

Method used

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  • Bulk drug phillyrin quality detection method
  • Bulk drug phillyrin quality detection method
  • Bulk drug phillyrin quality detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0170] 1. Preparation of raw material drug forsythin

[0171] Add 10 kg of 95% (m / m) ethanol to 1 kg of dried forsythia leaves, heat and reflux to extract twice, each time for 2 hours, filter, and concentrate the filtrate under reduced pressure to 1 / 2 of the original volume, place it at 25°C for 1 hour, and precipitate Precipitate; dissolve with methanol, recrystallize, and precipitate; repeat the above method for recrystallization with methanol to obtain the raw material drug forsythin in the state of amorphous powder.

[0172] The raw material drug forsythin is light yellow to yellow powder with certain hygroscopicity; it is odorless and tastes slightly bitter.

Embodiment 2

[0174] Add 10 kg of methanol to 1 kg of dried forsythia fruit, heat and reflux for extraction three times, each time for 4 hours, filter, and concentrate the filtrate under reduced pressure to 1 / 10 of the original volume, and place it at 20°C for 48 hours to precipitate out; then dissolve with ethanol, Carry out recrystallization and precipitate out; repeat the above method and recrystallize with ethanol to obtain the raw material drug forsythin in the state of amorphous powder.

[0175] The raw material drug forsythin is light yellow to yellow powder with certain hygroscopicity; it is odorless and tastes slightly bitter.

Embodiment 3

[0177] Add 10 kg of 70% (m / m) methanol to 1 kg of dried forsythia leaves, heat and reflux for extraction 3 times, 3 hours each time, filter, concentrate the filtrate under reduced pressure to 1 / 3 of the original volume, and place it at room temperature for 2 hours to precipitate out Dissolve it with 90% methanol, carry out recrystallization, and precipitate out; repeat the above method and recrystallize with methanol to obtain the raw material drug forsythin in the state of amorphous powder.

[0178] The raw material drug forsythin is light yellow to yellow powder with certain hygroscopicity; it is odorless and tastes slightly bitter.

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Abstract

The present invention discloses a bulk drug phillyrin quality detection method, which comprises: 1) identifying phillyrin, 2) determining the phillyrin content, and 3) detecting the related substance. According to the present invention, the method is mainly used for the quality control of the bulk drug phillyrin and the preparation thereof, and has characteristics of simpleness, stability, good repeatability, testing efficiency improving, and bulk drug phillyrin and preparation treatment effect ensuring.

Description

technical field [0001] The invention relates to a detection method of Chinese herbal medicine, in particular to a quality detection method of forsythin medicinal material. Background technique [0002] Flu is a kind of common disease, frequently-occurring disease, and clinical can be divided into two kinds of influenza (being flu) and common cold, and its cause of disease more than 80% is because upper respiratory tract virus infection causes. The common cold has mild symptoms, generally does not cause other diseases, and has self-healing properties; influenza can easily cause virus mutation, and may lead to viral pneumonia, viral myocarditis and other diseases. When influenza is severe, it can cause coma, convulsions, and even death, so influenza is more harmful to the human body. Therefore, urgently need to be solved to the treatment of influenza. [0003] Chinese herbal medicine has comprehensive effects such as inhibiting influenza virus replication, preventing virus-i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90
CPCG01N30/90
Inventor 鲁明明王硕付强王凯乾惠敏富力曲洪颖刘正贤盖鑫
Owner 富力
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